Long-term daily use of aspirin has been known to prevent colon cancer, but up to now it’s been unclear why that is. Now, researchers think they understand how aspirin acts against colon cancer, a new study says. Aspirin appears to boost aspects of the body’s immune response against cancer cells, according to findings published April 22 in the journal Cancer. “Our study shows a complementary mechanism of cancer prevention or therapy with aspirin besides its classical drug mechanism involving inhibition of inflammation,” said lead researcher Dr. Marco Scarpa, a general surgeon with the University of Padova in Italy. For the study, researchers obtained tissue samples from 238 patients who underwent surgery for colon cancer between 2015 and 2019. Of those, about 12% were aspirin users. Tissue samples from aspirin users showed less cancer spread to the lymph nodes, and more aggressive activity of immune cells against tumors, the researchers said. In the lab, they discovered that exposing colon cancer cells to aspirin enhanced the ability of immune cells to alert each other to the presence of tumors. Specifically, immune cells started expressing more of a protein called CD80. In patients with rectal cancer, aspirin users had higher CD80 expression in healthy tissue, suggesting that aspirin enhances the ability of the immune system to seek out and destroy cancer cells, researchers said. The next step will be to…  read on >  read on >

Active military service appears to increase a woman’s risk of having a low birthweight baby, a new review finds. Nearly two-thirds of studies (63%) conclude that women on active service could be at higher risk of having a baby with low birth weight, researchers reported April 22 in the journal BMJ Military Health. However, there was no clear evidence of an increased risk of stillbirth or premature birth among military women. “This review highlights a need for more female-specific research in armed forces, beyond the U.S. military setting, to inform military maternity pathways and policies in ways that safeguard mothers and their babies,” concluded the research team led by Dr. Kirsten Morris, with the London School of Hygiene & Tropical Medicine in the U.K. Increasing evidence has shown that stress during pregnancy is associated with birth complications, such as preterm delivery and low birth weight, researchers said in background notes. To assess the evidence, researchers pooled data from 21 studies involving more than 650,000 women in the U.S. military, all published between 1979 and 2023. Four out of five studies that compared active personnel to a control group — usually the wives of male soldiers — indicated an increased risk of low birthweight for the newborns of female service members, researchers said. The study shows the need for more research into the effects of military…  read on >  read on >

Soldiers can suffer brain injury if they are repeatedly exposed to explosive blasts, a new study shows. Further, the more frequently a soldier is exposed to explosions, the greater their risk for brain injury, researchers reported April 22 in the Proceedings of the National Academy of Sciences. Based on this, researchers intend to develop a diagnostic test to detect blast brain injury in military personnel. “The availability of a reliable diagnostic test could improve operators’ quality of life by ensuring that they receive timely, targeted medical care for symptoms related to repeated blast brain injury,” said co-senior researcher Yelena Bodien, an investigator with Massachusetts General Hospital’s Center for Neurotechnology and Neurorecovery. For this study, researchers followed 30 active-duty U.S. Special Operations Forces personnel. On average, the soldiers were 37 and had 17 years of military service. They all had extensive combat exposure and had high levels of blast exposure and blows to the head. Half had endured more blunt impacts to the head than they could recall. The soldiers underwent a series of brain scans focused on a region of the frontal lobe called the rostral anterior cingulate cortex, which is known to be a widely connected brain network hub that modulates cognition and emotion, researchers said. The scans showed an association between cumulative blast exposure and changes to this brain region, particularly with blast…  read on >  read on >

People who’ve survived a heart attack and have been given a stent may be better off quitting low-dose aspirin a month after the procedure, a new study finds. The strategy is “beneficial by reducing major and minor bleeding through one year by more than 50 percent,” said study lead author Dr. Gregg Stone, a professor of medicine (cardiology) and population health science and policy at the Icahn School of Medicine at Mount Sinai, in New York City. “Moreover, there was no increase in adverse ischemic [artery-blocking] events” when folks stopped using aspirin early, “meaning continuing aspirin was causing harm without providing any benefit,” Stone added. His team presented its findings Sunday at the American College of Cardiology (ACC) annual meeting in Atlanta. The study was published simultaneously in The Lancet. For folks who’ve had a heart attack or are at very high risk of experiencing one, low-dose daily aspirin is often given to cut their odds for blocked arteries. However, long-term use of aspirin is also tied to another health danger: Bleeding. So, the duration of aspirin use has long been up for debate. In the new trial, outcomes were tracked for up to a year in over 3,400 heart patients treated at 58 centers in four countries. All the patients had undergone non-surgical, catheter-guided placement of a heart stent to open up a blocked…  read on >  read on >

Ahead of a total solar eclipse arriving April 8, new research finds there was a temporary rise in U.S. traffic accidents around the time of a solar eclipse back in 2017. The area in the United States covered by the total eclipse seven years ago was relatively small (about 70 miles wide), but it was still tied to a 31% national rise in fatal traffic accidents.  “In absolute terms, this averaged to 1 extra crash-involved person every 25 minutes and 1 extra crash fatality every 95 minutes,” said a Canadian team led by Dr. Donald Redelmeier of Sunnybrook Health Sciences Centre, in Toronto.  His team suspects the rise in accidents didn’t owe to any temporary change in visibility due to the eclipse. Instead, it more likely stemmed from a surge in people traveling to view the rare phenomenon.  In 2017, the total eclipse had an estimated 20 million people traveling to another city to view it, the Toronto team said. More traffic danger might loom on April 8, however, since this time the eclipse “is within driving range for more than 200 million individuals within the US,” the study authors said. The new study relied on U.S. data from the National Highway Traffic Safety Administration Fatality Analysis Reporting System.   Redelmeier’s team looked at the three days before, during and immediately after the Aug. 17,…  read on >  read on >

After a car crash, women are more likely to go into shock than men, even when their injuries are less severe, new research shows. “Women are arriving to the trauma bay with signs of shock more often than men, regardless of injury severity,” said study leader Susan Cronn, a researcher at the Medical College of Wisconsin in Milwaukee. “We need to look further into how and why this is happening.” For the study, her team looked at clinical injury data from more than 56,000 car crash victims — half men, half women.  Even though men had more injuries overall, women suffered more injuries to the pelvis and liver, they found. More importantly, women surpassed a shock index greater than 1.0 more often than men. This was true even for those with fewer, less severe injuries.  Healthy adults have a normal shock index between 0.5 and 0.7.  Higher numbers may be a warning sign of a life-threatening condition called hemorrhagic shock, in which blood pressure, heart rate and body temperature plummet. Often caused by heavy blood loss, it can be a predictor of premature death. “Our findings might mean that women’s bodies have less capacity to function when physiological changes occur, that some injuries might have more impact on female bodies, or that female bodies handle blood loss differently than male bodies,” Cronn said. “It might…  read on >  read on >