Patients in the earliest stages of multiple sclerosis might develop certain symptoms that offer an early clue to the degenerative nerve disease, researchers report. Depression, constipation, urinary tract infections and sexual problems are all more likely in MS patients five years before their official diagnosis, compared with people who never develop MS, researchers found. Those conditions are also more likely to occur in people with other autoimmune diseases like lupus or Crohn’s disease, results show. These early signs “would not necessarily lead to earlier diagnosis of the disease in the general population, since these conditions are common and could also be signs of other diseases, but this information could be helpful for people who are at a higher risk of developing MS, such as people with a family history of the disease or those who show signs of MS on brain scans but do not have any symptoms of the disease,” said researcher Dr. Celine Louapre, an associate professor of neurology at  Sorbonne University in Paris. MS occurs when the immune system attacks the protective sheath that covers nerve fibers, causing progressive interruption of nerve signals between the brain and the body. For the study, Louapre and her colleagues compared more than 20,000 people newly diagnosed with MS with nearly 55,000 people who do not have MS. Each MS patient was matched with three healthy people…  read on >  read on >

New research challenges a long-held notion that human newborns enter the world with brains that are significantly less developed than those of other primates. Babies are born extremely helpless and with poor muscle control, and human brains grow much larger and more complex than other species following birth, investigators said. Because of those observations, it’s long been believed that human newborns have brains comparatively less developed than other primates at birth. But that’s a false impression, researchers report in the Dec. 4 issue of the journal Nature Ecology & Evolution. Analysis of brain development patterns in 140 different mammal species has provided new insight into the evolution of human brains, by taking into account factors like fetal gestation and comparative brain size of newborns to adults. “This new work changes the overall understanding around the evolution of human brain development,” said lead researcher Aida Gomez-Robles, an associate professor of anthropology at University College London. “Humans seem so much more helpless when they’re young compared to other primates, not because their brains are comparatively underdeveloped but because they still have much further to go,” Gomez-Robles added in a university news release. Scientists typically judge brain development of different species by comparing the size of their brains as newborns to their brain size as adults, researchers said in background notes. Humans are born with a brain that’s relatively…  read on >  read on >

People with epilepsy suffer quicker declines in thinking than people without the brain disorder, particularly if they also have risk factors like high blood pressure or diabetes, a new study finds. The difference was significant: Over the course of the 14-year study, those with epilepsy experienced a 65% to 70% faster decline in memory and thinking skills. On top of that, having risk factors for heart disease pushed that percentage 20% higher. “While epilepsy itself is associated with [mild cognitive impairment] and dementia, this risk is substantially magnified in those who also have high blood pressure, diabetes or other cardiovascular risk factors,” said lead researcher Dr. Ifrah Zawar, an assistant professor of neurology at the University of Virginia in Charlottesville. Researchers said their study is unique because it tracked the transition to mild cognitive impairment and dementia in more than 13,700 people who started the study with healthy brains. The participants were recruited at 39 Alzheimer’s disease centers across the United States between September 2005 and December 2021. Fewer than 1% had epilepsy, researchers said. The rate of decline from mild cognitive impairment to dementia was the same in patients with or without epilepsy. The researchers speculate that’s probably because heart risk factors play a much bigger role than epilepsy in the later stages of dementia. The findings were presented Friday at the American Epilepsy…  read on >  read on >

Gina Arata had a bright future, wrapping up college and preparing for law school, when a 2001 car wreck left her with lasting brain damage. After her recovery, Arata wound up taking a job sorting mail, but struggled even in that. “I couldn’t remember anything,” said Arata, who lives in Modesto with her parents. “My left foot dropped, so I’d trip over things all the time. I was always in car accidents. And I had no filter — I’d get pissed off really easily.” But Arata is doing much better now, thanks to a device that doctors surgically implanted deep inside her brain in 2018. The experimental deep-brain stimulator is carefully calibrated to feed electrical activity to neural networks damaged by Arata’s brain injury. Now, a new study from Stanford researchers details how such implants help patients with brain injuries recover some of their thinking skills. For Arata, the difference was immediate. For example, the device allowed her to rattle off a list of fruits and vegetables when asked to name items found in the produce aisle of a grocery store. But when a researcher turned the device off, she couldn’t name a single one. “Since the implant, I haven’t had any speeding tickets,” Arata added. “I don’t trip anymore. I can remember how much money is in my bank account. I wasn’t able to…  read on >  read on >