
Enlarged spaces in the brain that fill with fluid around small blood vessels may be a harbinger of impending dementia, a new Australian study suggests. Typically, these so-called perivascular spaces help clear waste and toxins from the brain and might be linked with changes in the aging brain, researchers say. “Dilated perivascular spaces, which are a common MRI finding, especially in the elderly, are not just an incidental finding,” said study author Dr. Matt Paradise, a psychiatrist and research fellow at the Centre for Healthy Brain Ageing at the University of New South Wales in Sydney. “Instead, they should be taken seriously, and assessing their severity may be able to help clinicians and researchers better diagnose dementia and help predict the trajectory of people with cognitive decline.” Paradise noted, however, that the study does not prove that enlarged perivascular spaces cause thinking and memory problems, only that there is an association. “Dilated perivascular spaces may be a marker of the disease process, but not necessarily drive it,” he explained. ‘The underlying mechanisms for dilated perivascular spaces are complex and need unraveling.” One neurologist agreed that relationship between these enlarged spaces and dementia is complicated. “We all have perivascular spaces. They are natural, but they’re usually very small, so small that when we do pictures of the brain, we don’t usually see them,” explained Dr. Glenn… read on > read on >