Regular brushing and flossing can save your teeth into old age. Could it also save your brain? The bacteria involved in gum disease might play a key role in the development of Alzheimer’s disease, new research suggests. DNA from the bacterium Porphyromonas gingivalis is more often found in the brains of Alzheimer’s patients, said lead researcher Jan Potempa, a professor at the University of Louisville School of Dentistry in Kentucky. P. gingivalis is one of the causes of periodontitis, the most serious type of gum disease. “The DNA can be found in the Alzheimer’s brain, but less frequently at a lower level in the brain of people who died at the same age from causes other than Alzheimer’s,” Potempa said. Alzheimer’s-affected brains also contain higher levels of a toxin secreted by P. gingivalis called gingipain, he said. Potempa and his colleagues think the bacteria and its toxins might be connected with Alzheimer’s disease, a suspicion supported by their research involving laboratory mice. Researchers infected the mouths of mice with P. gingivalis and found that the bacteria did spread into the brain. The infection appeared to increase production of amyloid beta, a protein linked to Alzheimer’s, and also caused inflammation in the brain. The researchers also found that a drug targeting gingipain blocked movement of the bacteria into the brains of the mice. The experimental drug,… read on >

















