COVID Hospital Patients Face Increased Risk Of Death For 2+ Years Afterward

FRIDAY, Feb. 28, 2025 (HealthDay News) People hospitalized for a severe bout of COVID-19 are far from in the clear after they’ve recovered enough to return home, a new study says.

COVID hospital patients have an increased risk of death from any cause for at least two and a half years following their initial illness, researchers reported in a new study published in the journal Infectious Diseases.

They also are more likely to be hospitalized again, with particularly high risk for neurological, psychiatric, heart and lung problems, researchers found.

“These findings are a stark reminder of the far-reaching impact of COVID-19, which extends far beyond the initial infection,” lead researcher Dr. Sarah Tubiana, an infectious disease specialist at Bichat Hospital in Paris, said in a news release.

“While much attention has been given to the immediate dangers of the virus, our research shows that hospitalized COVID-19 survivors remain at greater risks of severe health complications months and even years later,” Tubiana said. “The long-term implications for public health are significant.”

For the study, researchers followed nearly 64,000 French adults admitted to a hospital with COVID between January 2020 and August 2020.

The team compared their health with nearly 320,000 other people matched for age, sex and location who had not been hospitalized for COVID during the same period.

During follow-up for up to 30 months, researchers found that hospitalized COVID survivors had a higher rate of deaths from any cause — 5,218 deaths for every 100,000 person-years, compared with 4,013 deaths among the healthy control group.

Person-years is a statistical measure of the number of people considered in a study, as well as the amount of time they were followed.

COVID survivors also landed in the hospital again more frequently, with 16,334 hospitalizations per 100,000 person-years compared with 12,024 hospitalizations among the control group.

COVID patients specifically were twice as likely to be hospitalized again for respiratory problems, researchers found. They also were 15% more likely to be hospitalized for heart problems, 41% more likely for psychiatric problems and 50% more likely for neurological disorders.

These excess risks decreased after the first six months following hospitalization, but remained elevated for up to 30 months for neurological and respiratory illnesses, chronic kidney failure and diabetes, results show.

“Even 30 months after hospitalization, COVID-19 patients remained at an increased risk of death or severe health complications, reflecting the long-lasting, wider consequences of the disease on people’s lives,” senior researcher Dr. Charles Burdet, an infectious diseases specialist at Université Paris Cité, said in a news release.

“These results highlight the need for further research to understand the mechanisms behind these long-term health risks and how to mitigate them,” he added.

COVID is known to damage organs and systems throughout the body, particularly during severe, life-threatening infections, researchers noted.

However, researchers added that these risks might not fully apply to people who’ve more recently been hospitalized with COVID, as the study focused on patients infected before new variants of the coronavirus emerged.

More information

The U.S. Centers for Disease Control and Prevention has more about long COVID.

SOURCES: Taylor & Francis, news release, Feb. 28, 2025; Infectious Diseases, Feb. 28, 2025