Biomarkers in sperm may help identify men at risk of fathering children with autism, researchers say. For the study, investigators examined sperm epigenetics — the molecular processes that affect gene expression — in 13 men who fathered sons with autism and 13 who had children without the disorder. The American and Spanish researchers focused specifically on DNA methylation, a chemical modification that can turn genes on or off. “We can now potentially use this to assess whether a man is going to pass autism on to his children,” said study co-author Michael Skinner, professor of biological sciences at Washington State University, in Pullman, Wash. “It is also a major step toward identifying what factors might promote autism,” he said in a university news release. The study found 805 different DNA methylation regions that could be epigenetic biomarkers, indicating men more likely to have children with autism. To test their findings about these biomarkers, the researchers used sperm samples from 18 men to see if they could identify those with and without children with autism. The results were 90% accurate, according to the study. But Skinner and his colleagues said more research must be done before this approach can be used in clinical practice. The team is now working on a larger study involving 100 men. “We found out years ago that environmental factors can alter…  read on >  read on >

When journalist Catherine Guthrie learned that she would need to have a mastectomy following a breast cancer diagnosis, she was shocked by what seemed like a cursory explanation from her surgeon about what would happen next. That included removing both of her breasts, adding implants, and moving a muscle from her back to her chest to make the results look more natural. It didn’t feel right to her. She went home, thought about it and decided to “go flat.” “I feel great about it. I love my body. I love the freedom I have in my body. I love that I have full mobility and strength in my body. I’m as flexible and strong now 10, 11 years later as I was then,” said Guthrie, who already had back issues and had been concerned about how the surgery would impact that. “I absolutely have zero regrets.” Guthrie’s choice mirrors a growing trend: A new study found that a majority of breast cancer patients — 74% — who had opted to “go flat” were satisfied with the outcome. The study, from University of California, Los Angeles (UCLA) Jonsson Comprehensive Cancer Center, also found that 22% of women who responded to the survey had experienced what they refer to as “flat denial,” which is where the surgeon either did not initially offer this choice, didn’t support the…  read on >  read on >

Many Americans most affected by the COVID-19 pandemic don’t believe that racism is associated with poorer health, a nationwide poll shows. The ongoing poll of more than 4,000 lower- and middle-income Americans focuses on communities of color. “It really struck us that — despite the virus’s spread across the country to all types of communities — there’s not a consensus view on the effects of systemic racism,” said lead author Katherine Grace Carman, a senior economist at RAND Corporation. RAND is conducting the poll, with support from the Robert Wood Johnson Foundation. “Respondents see the impact of low incomes and living in a rural community on a person’s health, but race isn’t viewed with the same gravity,” she said in a Robert Wood Johnson news release.Just over 42% of respondents say systemic racism is one of the main reasons people of color have poorer health. About one-third disagree, and about a quarter are neutral. Black respondents are much more likely (69.4%) than white ones (33.2%) to believe that systemic racism affects the health of people of color, according to the poll. Overall, pollsters found a slight increase in respondents’ willingness to risk their own health to return to pre-pandemic “normal.” But respondents who are Black or Hispanic are more likely (68.5%) to be cautious about taking health risks to move about freely than white respondents…  read on >  read on >

Biomarkers in sperm may help identify men at risk of fathering children with autism, researchers say. For the study, investigators examined sperm epigenetics — the molecular processes that affect gene expression — in 13 men who fathered sons with autism and 13 who had children without the disorder. The American and Spanish researchers focused specifically on DNA methylation, a chemical modification that can turn genes on or off. “We can now potentially use this to assess whether a man is going to pass autism on to his children,” said study co-author Michael Skinner, professor of biological sciences at Washington State University, in Pullman, Wash. “It is also a major step toward identifying what factors might promote autism,” he said in a university news release. The study found 805 different DNA methylation regions that could be epigenetic biomarkers, indicating men more likely to have children with autism. To test their findings about these biomarkers, the researchers used sperm samples from 18 men to see if they could identify those with and without children with autism. The results were 90% accurate, according to the study. But Skinner and his colleagues said more research must be done before this approach can be used in clinical practice. The team is now working on a larger study involving 100 men. “We found out years ago that environmental factors can alter…  read on >  read on >

Biomarkers in sperm may help identify men at risk of fathering children with autism, researchers say. For the study, investigators examined sperm epigenetics — the molecular processes that affect gene expression — in 13 men who fathered sons with autism and 13 who had children without the disorder. The American and Spanish researchers focused specifically on DNA methylation, a chemical modification that can turn genes on or off. “We can now potentially use this to assess whether a man is going to pass autism on to his children,” said study co-author Michael Skinner, professor of biological sciences at Washington State University, in Pullman, Wash. “It is also a major step toward identifying what factors might promote autism,” he said in a university news release. The study found 805 different DNA methylation regions that could be epigenetic biomarkers, indicating men more likely to have children with autism. To test their findings about these biomarkers, the researchers used sperm samples from 18 men to see if they could identify those with and without children with autism. The results were 90% accurate, according to the study. But Skinner and his colleagues said more research must be done before this approach can be used in clinical practice. The team is now working on a larger study involving 100 men. “We found out years ago that environmental factors can alter…  read on >  read on >

When journalist Catherine Guthrie learned that she would need to have a mastectomy following a breast cancer diagnosis, she was shocked by what seemed like a cursory explanation from her surgeon about what would happen next. That included removing both of her breasts, adding implants, and moving a muscle from her back to her chest to make the results look more natural. It didn’t feel right to her. She went home, thought about it and decided to “go flat.” “I feel great about it. I love my body. I love the freedom I have in my body. I love that I have full mobility and strength in my body. I’m as flexible and strong now 10, 11 years later as I was then,” said Guthrie, who already had back issues and had been concerned about how the surgery would impact that. “I absolutely have zero regrets.” Guthrie’s choice mirrors a growing trend: A new study found that a majority of breast cancer patients — 74% — who had opted to “go flat” were satisfied with the outcome. The study, from University of California, Los Angeles (UCLA) Jonsson Comprehensive Cancer Center, also found that 22% of women who responded to the survey had experienced what they refer to as “flat denial,” which is where the surgeon either did not initially offer this choice, didn’t support the…  read on >  read on >

Many Americans most affected by the COVID-19 pandemic don’t believe that racism is associated with poorer health, a nationwide poll shows. The ongoing poll of more than 4,000 lower- and middle-income Americans focuses on communities of color. “It really struck us that — despite the virus’s spread across the country to all types of communities — there’s not a consensus view on the effects of systemic racism,” said lead author Katherine Grace Carman, a senior economist at RAND Corporation. RAND is conducting the poll, with support from the Robert Wood Johnson Foundation. “Respondents see the impact of low incomes and living in a rural community on a person’s health, but race isn’t viewed with the same gravity,” she said in a Robert Wood Johnson news release.Just over 42% of respondents say systemic racism is one of the main reasons people of color have poorer health. About one-third disagree, and about a quarter are neutral. Black respondents are much more likely (69.4%) than white ones (33.2%) to believe that systemic racism affects the health of people of color, according to the poll. Overall, pollsters found a slight increase in respondents’ willingness to risk their own health to return to pre-pandemic “normal.” But respondents who are Black or Hispanic are more likely (68.5%) to be cautious about taking health risks to move about freely than white respondents…  read on >  read on >

Biomarkers in sperm may help identify men at risk of fathering children with autism, researchers say. For the study, investigators examined sperm epigenetics — the molecular processes that affect gene expression — in 13 men who fathered sons with autism and 13 who had children without the disorder. The American and Spanish researchers focused specifically on DNA methylation, a chemical modification that can turn genes on or off. “We can now potentially use this to assess whether a man is going to pass autism on to his children,” said study co-author Michael Skinner, professor of biological sciences at Washington State University, in Pullman, Wash. “It is also a major step toward identifying what factors might promote autism,” he said in a university news release. The study found 805 different DNA methylation regions that could be epigenetic biomarkers, indicating men more likely to have children with autism. To test their findings about these biomarkers, the researchers used sperm samples from 18 men to see if they could identify those with and without children with autism. The results were 90% accurate, according to the study. But Skinner and his colleagues said more research must be done before this approach can be used in clinical practice. The team is now working on a larger study involving 100 men. “We found out years ago that environmental factors can alter…  read on >  read on >

It’s a woman’s worst nightmare: You’re having a C-section under anesthesia, but you suddenly become aware of what is happening during your surgery. Now, a new study shows that phenomenon, known as “accidental awareness,” is more common than believed. In fact, it may occur in 1 in 256 women who have obstetric surgery and some may suffer long-term psychological harm. Accidental awareness is when a patient is temporarily conscious during general anesthetic and can remember things that occurred during surgery, such as feeling pain or being unable to move. It’s most likely to occur at the very start or end of a general anesthetic, as the patient is going to sleep or waking up. In this study, researchers analyzed data from more than 3,000 women who had general anesthesia for obstetric procedures at 72 National Health Service hospitals in England. The study authors identified 12 reports of accidental awareness, including seven patients who were distressed and five who felt paralyzed. Two patients described paralysis with pain. Other sensations reported by patients while under anesthesia included tugging, stitching, feelings of dissociation and being unable to breathe. Long-term psychological harm associated with accidental awareness often included symptoms of post-traumatic stress disorder, according to the study published Jan. 12 in the journal Anaesthesia. “We identified a complex range of risk factors for awareness, including drug types and variations…  read on >  read on >