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An imbalance in the gut “microbiome” of people with lupus may be driving the chronic autoimmune disease as well as its flare-ups, new research suggests. The microbiome is the trillions of helpful bacteria that coexist in the human digestive tract and elsewhere in the body. Comparing gut bacteria from lupus patients with bacteria from their healthy peers, scientists learned those with lupus had about five times more of the bacteria known as Ruminococcus gnavus. The discovery may lead to better treatments for lupus, which can damage the skin, joints and organs, study author Dr. Gregg Silverman said. “Current lupus therapies seek to dampen or destroy the immune system,” said Silverman, a professor of medicine and pathology at NYU Langone Health in New York City. “The idea that we might find in some patients that their disease is being worsened by bacteria in their intestine may mean we [find] much more benign therapeutic approaches,” he added. “This is something I’m excited about because I think it really relates to the health and well-being of patients and people.” Lupus affects an estimated 5 million people worldwide, according to the Lupus Foundation of America. The cause of the sometimes-fatal disease is unknown, though genetics are believed to play a role. Symptoms can vary and include joint and muscle pain, rashes, hair loss, fatigue and swelling in various body… read on >