Wild and feral cats appear to release more toxoplasmosis parasites in places densely populated with people, new research suggests. These cats also “shed” more when the temperature is warmer, a significant finding given climate change, according to the report published online June 21 in PLOS ONE. Policymakers could help protect humans from this illness by better managing these stray cat populations, the researchers said. “Changes from climate or human activities can affect disease transmission in ways that we don’t fully understand yet,” said study author Sophie Zhu, of the University of California, Davis, and colleagues. “In our study, we can see how these factors may be associated with changes in Toxoplasma shedding by cats, which in turn can affect the risk of exposure to vulnerable people and wildlife,” the researchers explained in a journal news release. Toxoplasmosis is a mild-to-severe disease that can be especially dangerous in pregnancy. It is caused by Toxoplasma gondii, which can affect humans and many wild and domestic animals. Cats, sheep, mice, birds and sea otters are among the vulnerable creatures. Humans can become infected when they accidentally come in contact with an infected cat’s feces. This can happen unknowingly while gardening, for example. While most T. gondii transmission is driven by domestic cats shedding the parasite at a stage of its life cycle known as oocyst, research has tended…  read on >  read on >

Living in a walkable neighborhood fosters socialization and helps create a strong sense of community, new research shows. Among the active behaviors these walkable neighborhoods promote are walking for leisure or as transportation to school, work shopping or home. “Our built environments create or deny long-lasting opportunities for socialization, physical activity, contact with nature and other experiences that affect public health,” said senior study author James Sallis, a professor at the Herbert Wertheim School of Public Health at the University of California, San Diego. “Transportation and land use policies across the U.S. have strongly prioritized car travel and suburban development, so millions of Americans live in neighborhoods where they must drive everywhere, usually alone, and have little or no chance to interact with their neighbors,” Sallis added in a university news release. Data came from the Neighborhood Quality of Life Study, which included 1,745 adults ages 20 to 66 living in 32 neighborhoods located in and around Seattle, Baltimore and Washington, D.C. In walkable neighborhoods, people can wave hello to a neighbor, ask for help or socialize in their homes, said study first author Jacob Carson, a student in the UC San Diego – San Diego State University Joint Doctoral Program in Public Health. Neighborhoods where driving is necessary may have the opposite effect, preventing neighbors from socializing. “Promoting social interaction is an important public…  read on >  read on >

It’s common knowledge that loss is a part of male aging — loss of hair, loss of muscle tone, loss of vision or hearing. But men growing older also start losing the very thing that makes them biological males, their Y chromosome, and that can leave them more vulnerable to cancer, a new study says. The loss of the Y chromosome can help cancer cells evade detection by the body’s immune system, according to researchers from Cedars-Sinai Medical Center, in Los Angeles. Specifically, it results in more aggressive bladder cancer among men, the study authors reported June 21 in the journal Nature. “This study for the first time makes a connection that has never been made before between loss of the Y chromosome and the immune system’s response to cancer,” said researcher Dr. Dan Theodorescu, director of Cedars-Sinai Cancer. “We discovered that loss of the Y chromosome allows bladder cancer cells to elude the immune system and grow very aggressively,” Theodorescu said in a medical center news release. It’s not all bad news, however. Bladder cancers driven by the loss of the Y chromosome also were more vulnerable to immune checkpoint inhibitors, which are drugs that enhance the body’s ability to target and destroy tumor cells, the researchers explained. Each human cell normally has one pair of sex chromosomes. Men’s cells have one X and…  read on >  read on >

New research on horses and dogs found elevated levels of PFAS “forever chemicals,” establishing horses as sentinel species. Sentinel species provide advance warning of a danger to people. The work also advanced knowledge about PFAS exposure and liver and kidney function in these animals. PFAS stands for per-and polyfluoroalkyl substances, a group of chemicals used in plastics and grease- and water-resistant materials. They’re a health concern because they don’t break down in the environment and are found in soil and water sources. “Horses have not previously been used to monitor PFAS exposure,” said first author Kylie Rock, a postdoctoral researcher at North Carolina State University. “But they may provide critical information about routes of exposure from the outdoor environment when they reside in close proximity to known contamination sources.” In the new study, researchers detected elevated PFAS levels in the blood of 31 pet dogs and 32 horses from Grays Creek, N.C., including dogs that drank only bottled water. The study was conducted at the request of residents concerned about their pets’ well-being. Their homes used wells that state inspectors had determined to contain PFAS. Animals each had a general veterinary health check, as well as blood tests to screen for 33 PFAS chemicals. The chemicals were chosen based on compounds present in the Cape Fear River basin and the availability of standards to analyze…  read on >  read on >

For the first time ever, the nation’s top panel of preventive health experts has recommended that doctors routinely screen all adult patients under 65 for anxiety disorder. Evidence now shows that anxiety screening can help those patients find peace of mind, the U.S. Preventive Services Task Force (USPSTF) said in recommendations that were published online June 20 in the Journal of the American Medical Association. “The task force found that for the patients who are 19 to 64, what we call the general adult population, the evidence was robust on reducing their symptoms of anxiety. There was also benefit around general quality of life as well,” USPSTF vice chair Dr. Michael Silverstein said. The task force also reiterated its longstanding recommendation that adults receive regular depression screening. “We were able to identify effective practices to screen the adult population for common and serious mental health disorders,” Silverstein said. “The good news is that screening for depression and anxiety can identify these conditions early. When this screening is linked to quality mental health care, patients benefit.” However, the task force did not recommend anxiety screening for seniors. “In the population 65 and older, we didn’t see the same quality of evidence that spoke to those outcomes,” said Silverstein, a professor of health services, policy and practice at the Brown University School of Public Health in Rhode…  read on >  read on >

In the face of an ongoing and widespread legal assault on transgender rights — one that threatens to cut off access to critical aspects of trans health care — a pair of new studies suggest that gender-affirming medical care is a lifesaving treatment for those who need it. One study finds that when trans men get immediate access to hormone/testosterone therapy as part of a gender-affirming treatment plan, their mental health improves markedly. Another finds that when trans teens embark on hormone therapy they rarely, if ever, regret their decision. “Gender-affirming hormone therapy is hormone treatment to align physical characteristics — such as facial hair, changes to muscle mass or body fat — with an individual’s gender identity,” explained study author Brendan Nolan, an endocrinologist with Austin Health in Melbourne, Australia. “For people desiring ‘masculinization,’ this involves the same doses and types of testosterone used to treat cisgender men [when someone’s sex at birth matches their own gender identity] with low testosterone,” added Nolan, who is pursuing his doctorate at the University of Melbourne. For the study, Nolan’s team tracked how 64 adult trans men fared over a three-month period. All wanted to begin testosterone treatment immediately. But only half were allowed to do so. The other half was told to ride out a standard three-month waiting list. “We found that the people who received…  read on >  read on >

(HealthDay news) — Fatty liver disease is increasing rapidly among Americans, outpacing obesity rates across many racial groups and affecting the liver health of millions, a new study reports. Overall, metabolic dysfunction-associated fatty liver disease (MAFLD) in Americans increased 131% during the past three decades, rising from 16% in 1988 to 37% in 2018, the researchers said. By comparison, obesity only increased by 74% during the same period, affecting 40% of Americans by 2018, according to findings presented Friday at the Endocrine Society’s annual meeting, in Chicago. “This is an important condition that seems to be getting worse over time,” said Dr. Theodore Friedman, chair of internal medicine at the Charles R. Drew University of Medicine & Science, in Los Angeles. “The rate has increased more than the rate of obesity in the United States.” Fatty liver disease occurs when excess fat begins to be stored in the liver, causing inflammation and eventually scarring, Friedman said. It’s akin to foie gras or pate, which is created by overfeeding ducks or geese. “Most people can live with fatty liver disease, but some people progress to the liver not working, cirrhosis of the liver or liver cancer,” Friedman said. Some with fatty liver disease need an organ transplant, Friedman said. “I think it’s less than 1%. It’s not that often,” Friedman said of liver transplants. “But because…  read on >  read on >

There is an epidemic of loneliness and isolation today, and the consequences can be deadly, researchers say. Folks who reported that they were socially isolated or felt lonely were more likely to die early from all causes including cancer, according to a sweeping review of 90 studies that included more than 2.2 million people from around the globe. Exactly how loneliness or social isolation affects a person’s health and well-being is not fully understood, but many theories exist, the researchers reported. People who are socially isolated or lonely may be less likely to eat a healthy diet and get regular exercise and more likely to smoke and consume alcohol. In addition, social isolation is linked to inflammation and weakened immune systems. People who are socially isolated may be less likely to receive medical care due to their smaller social networks. Social isolation and loneliness are not one and the same, the researchers pointed out. Social isolation refers to a lack of contact with other people. By contrast, loneliness is the feeling of being alone, regardless of social contact. For the study, researchers led by Maoqing Wang and Yashuang Zhao from Harbin Medical University in China reviewed 90 studies. Folks who reported being socially isolated and feeling lonely were more likely to die early from all causes including cancer. What’s more, social isolation was linked to…  read on >  read on >