The U.S. Food and Drug Administration on Friday approved a new pill, called zuranolone, that may quickly ease severe postpartum depression and help millions of women regain their emotional equilibrium following childbirth. Taken as a pill once a day for two weeks, zuranolone (Zurzuvae) showed “rapid, significant and sustained” reductions in depressive symptoms when compared to a placebo, according to a recent study of nearly 200 women, the FDA said. These improvements occurred in as few as three days and were still evident 28 and 45 days later. That’s compared to the many weeks it typically takes for standard antidepressants to start taking full effect. “Postpartum depression is a serious and potentially life-threatening condition in which women experience sadness, guilt, worthlessness — even, in severe cases, thoughts of harming themselves or their child. And, because postpartum depression can disrupt the maternal-infant bond, it can also have consequences for the child’s physical and emotional development,” Dr. Tiffany Farchione, director of the Division of Psychiatry in the FDA’s Center for Drug Evaluation and Research, said in an agency statement. “Having access to an oral medication will be a beneficial option for many of these women coping with extreme, and sometimes life-threatening, feelings.” As many as 1 in 8 women in the United States develops depression just before or after giving birth. “Women report severe sadness or loss… read on > read on >
All Lifestyle:
Steroids That Can Save Preemie Babies May Have Health Downsides
FRIDAY, Aug, 4, 2023Steroids are often unnecessarily prescribed to pregnant women thought to be at risk of preterm birth, a new evidence review contends. As a result, millions of babies are needlessly exposed to long-term health problems associated with steroid use in gestation, such as increased risk of infection and delayed brain development, researchers say. Steroids can’t prevent preterm birth, but they can accelerate the maturation of developing organs and give preemies a fighting chance for survival, said lead researcher Dr. Sarah McDonald, a professor of obstetrics at McMaster University in Ontario, Canada. However, two out of every five infants given steroids in the womb wound up being born full-term anyway, according to pooled data on 1.6 million babies from 17 previous studies. Compared to other at-term babies not given steroids, those infants had an increased risk of requiring neonatal intensive care, being put on a respirator, and developing long-term brain development and behavioral disorders, according to the review published Aug. 2 in the BMJ. “I like to say that steroids are powerful medications, and with great power comes great responsibility,” McDonald said. “We need to try to tailor the administration of these medications to pregnancies that are really at risk of preterm birth so we’re not exposing babies who go on and be born at term to these powerful medications.” In the same issue… read on > read on >
More Typos: Workers’ Mistakes Rise on Fridays, Study Shows
Workers may sense it intuitively but their mouse clicks prove it: Friday afternoon is the least productive time of the work week. It’s also when workers make the most typos. A Texas A&M University team studied this using the computer usage metrics of 789 in-office employees at a large energy company over two years. “Most studies of worker productivity use employee self-reports, supervisory evaluations or wearable technology, but these can be subjective and invasive,” said co-author Mark Benden, head of the university’s Department of Environmental and Occupational Health. “Instead, we used computer usage metrics — things like typing speed, typing errors and mouse activity — to get objective, noninvasive data on computer work patterns,” he said in a university news release. The researchers compared computer use across different days of the week and times of the day to see what kinds of patterns emerged. “We found that computer use increased during the week, then dropped significantly on Fridays,” said study leader Taehyun Roh, an assistant professor of epidemiology and biostatistics. “People typed more words and had more mouse movement, mouse clicks and scrolls every day from Monday through Thursday, then less of this activity on Friday.” Computer use fell off every afternoon — especially on Fridays — the data revealed. “Employees were less active in the afternoons and made more typos in the afternoons —… read on > read on >
Think Your Job Is ‘Socially Useless’? You’re Not Alone
Ever feel like your job is pointless? A big part of the population feels just that way — that the jobs they do matter little to society. And a Swiss study that delved into what’s been dubbed the “bullshit jobs theory” found that feeling was especially likely for folks in financial, sales and management jobs. About 19% of employees found their work rarely or never gave them “a feeling of making a positive impact on community and society” and “the feeling of doing useful work,” the study found. That finding is in line with the “bullshit jobs theory” espoused by the late American anthropologist David Graeber, who maintained that some jobs are socially useless. “Employees’ assessment of whether their work is perceived as socially useless is a very complex issue that needs to be approached from different angles,” study leader Simon Walo, a sociologist at the University of Zurich, said in a university news release. “It depends on various factors that do not necessarily have anything to do with the actual usefulness of work as claimed by Graeber. For example, people may also view their work as socially useless because unfavorable working conditions make it seem pointless,” Walo explained. In addition to Graeber’s theory, other researchers have suggested that people consider their jobs useless not because of the importance of their work but because it… read on > read on >
One Personality Type Is More Prone to Be an Anti-Vaxxer
When studying which personality types were more likely to resist getting vaccines, researchers got a surprise. It was the extroverts who were more vaccine resistant. Compared to other personality styles, extroverts were 18% more likely to refuse the COVID-19 vaccine, the new study finds. “We expected that people who were especially high in extroversion would be more likely to get the vaccine,” said lead author Melissa Baker, an assistant professor at the University of Texas at El Paso. “We figured those people would want to get back out in the world and socialize, right? It’s actually the opposite,” she added in a university news release. The researchers hope their findings may help with future public health messaging and vaccination campaigns. “We wanted to look at vaccine hesitancy a different way,” Baker said. “Of course, politics can help explain some of it, but there are personal differences between people, too — and that led us to this personality aspect.” Joining with a researcher from the University of Toronto, the study team used surveys of more than 40,000 Canadian adults, taken between November 2020 and July 2021. Questions evaluated each participant’s personality, based on a model known as “big five.” This gauges someone’s openness, conscientiousness, extraversion, agreeableness and emotional stability. Other questions were focused on vaccination, including, “When a COVID-19 vaccine becomes available, will you be vaccinated?”… read on > read on >
Troubled Childhood Could Mean a Troubled Old Age, Study Finds
The trauma and unhappy family dynamics of childhood may follow kids into old age, affecting both their mind and body, according to new research. “We looked at self-reported disability, as well as objectively measured physical and cognitive impairment, and learned that early-life stressful experiences can have ramifications all the way into older age,” said senior author Dr. Alison Huang, a University of California, San Francisco professor of medicine. “This can mean a higher likelihood of difficulty walking, or carrying out activities of daily living, or problems with memory when people are in their 60s, 70s, 80s or older,” she said in a university news release. Exposure to physical violence or abuse, severe illness, family financial stress or separation from parents are considered major childhood stressors. The study found that those who experienced violence in childhood were 40% more likely to have mobility impairment and 80% more likely to have difficulty with daily activities. Those who came from unhappy families were 40% more likely to have mild cognitive impairment. According to the U.S. Centers for Disease Control and Prevention, almost 60% of adults in the United States have experienced one or more types of adverse childhood experiences. These can undermine a child’s sense of safety or stability, and are tied to later heart disease, diabetes, autoimmune disease and depression. California was the first state to mandate… read on > read on >
Taking Kratom Claimed Her Son’s Life. Now She and Others Are Warning of the Dangers
J.D. Butler was planning a future with his girlfriend at his favorite New York City restaurant when that future came to a sudden, crushing halt. “They were planning on when she was moving in and arranging floor plans on the table, with where the furniture was going to go,” said his mother, Karen Butler, a lifelong New York resident. “And he had a grand mal seizure, and then his heart stopped.” A subsequent autopsy revealed that J.D.’s fatal seizure was brought on by mitragynine toxicity, caused by long-term ingestion of the widely used herbal supplement kratom, Butler said. “She said there was evidence in his organ tissue that it had been in his body consistently for a while,” Butler said. “It’s one of those drugs to which you develop a tolerance, so you have to keep taking more and more and more.” Kratom is coming under fire in the United States, targeted by a series of lawsuits following wrongful deaths associated with its use. A Florida jury awarded $11 million last week to the family of a woman who died after taking kratom, in a lawsuit against the company that sold her the supplement, according to NBC News. The woman, a 39-year-old mother of four, collapsed in her kitchen while making breakfast for her family in June 2021. A coroner said Krystal Talavera died from… read on > read on >
Bullying Could Help Bring on Headaches for Teens
So, your high schooler has been complaining of headaches. Should you worry? Maybe, claims new research that finds bullying and suicidal thoughts are both linked to more frequent headaches in teens. “Headaches are a common problem for teenagers, but our study looked beyond the biological factors to also consider the psychological and social factors that are associated with headaches,” said study author Dr. Serena Orr, of the University of Calgary, in Canada. “Our findings suggest that bullying and attempting or considering suicide may be linked to frequent headaches in teenagers, independent of mood and anxiety disorders.” This isn’t proof that bullying causes headaches, but shows an association between the two. A study limitation is that headaches were self-reported. The research included more than 2.2 million teens who were an average age of 14. About 0.5% of all the participants self-reported being gender-diverse, including transgender or nonbinary. The participants answered questions about their headaches, including if they had them in the past six months and how often. The teens also answered questions regarding mental health, including whether they had diagnosed mood or anxiety disorders or both; about bullying in the past year and about suicidal thoughts and attempts. About 11% of participants reported having frequent, recurring headaches, defined as headaches occurring more than once a week. About 25% of the participants reported being victims of frequent… read on > read on >
Millions of Smokers May Have a Tough-to-Diagnose Lung Disease
Millions of American smokers suffer from a potentially serious lung disease that’s not technically chronic obstructive pulmonary disease (COPD), a new study finds. They would benefit from a clear diagnosis, though, and the new findings demonstrate a major gap in care for people with a history of tobacco use, the researchers said. Among folks who smoked at least one pack of cigarettes a day for 20 or more years, half had persistently high respiratory symptoms, including shortness of breath, daily cough and phlegm, and decreased ability to exercise, although they did well in the breathing tests used to spot COPD. The researchers call the condition “tobacco exposure preserved spirometry” (TEPS). “We first described TEPS in 2016. What we’re showing here is the long-term follow up, and it’s not like an early COPD. It stays persistent the way it is over time,” said lead researcher Dr. Prescott Woodruff, division chief of pulmonology at the University of California, San Francisco. Right now, there is no treatment for TEPS, he said. “It does improve in many people when they stop smoking, but not everyone,” Woodruff said. Woodruff’s team tried treating patients with bronchodilators used to treat COPD. The drugs improved lung function but not the symptoms, he said. “TEPS may be due to abnormal mucus production, so therapies that could control mucus might be the best therapies,” Woodruff… read on > read on >
Pill to Counter Postpartum Depression Looks Good in Trial, May Gain FDA Approval
All eyes are on the U.S. Food and Drug Administration this week as the agency weighs approval of a new pill that may quickly treat and ease severe postpartum depression. Approval of the drug could help millions of women regain their emotional equilibrium following childbirth. The FDA’s decision is expected by Friday. Taken as a pill once a day for two weeks, zuranolone showed “rapid, significant and sustained” reductions in depressive symptoms when compared to a placebo, or dummy pill, according to a recent study of nearly 200 women. These improvements occurred in as few as three days and were still evident 28 and 45 days later, said study author Dr. Kristina Deligiannidis. She is a professor at the Institute of Behavioral Science at the Feinstein Institutes for Medical Research in Manhasset, N.Y. As many as 1 in 8 women in the United States develops depression immediately before or after giving birth. “Women report severe sadness or loss of interest in pleasurable activities and relationships, have significant guilt, often about not being a good enough mother or partner, low energy, poor concentration and indecisiveness, loss of appetite and irritability,” Deligiannidis said. Many also say they feel overwhelmed and are anxious, especially over the baby’s well-being, she added. Some women may start to believe that their family would be better off if they were dead, she… read on > read on >