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Patients with schizophrenia or bipolar disorder tend to see their conditions ease after four months on the ketogenic (“keto”) diet, a small pilot study finds. While no one is saying the diet should replace standard medications, the researchers believe it could provide additional help for some. “It’s very promising and very encouraging that you can take back control of your illness in some way, aside from the usual standard of care,” said study first author Dr. Shebani Sethi. She’s an associate professor of psychiatry and behavioral sciences at Stanford University. The findings were published March 27 in the journal Psychiatric Research. Sethi said she first noticed there might be a connection between the keto diet and psychiatric health when she was working as a student in a clinic focused on obesity and weight loss. Many people with psychiatric conditions gain excess weight due to medication side effects. Sethi was helping to treat one such patient, who had schizophrenia. The patient’s auditory hallucinations (“hearing voices” can be a common symptom of schizophrenia) quieted down after being on the keto diet, she said. A search of the literature turned up little regarding using the diet to counter schizophrenia, but there was evidence it could ease epileptic seizures. Apparently the diet did so “by reducing the excitability of neurons in the brain,” Sethi explained in a Stanford news…  read on >  read on >

Expecting or new mothers are much more likely these days to be diagnosed with anxiety, depression and post-traumatic stress disorder, new research shows. However, more women are also getting treated for these problems rather than roughing it out, researchers report in April 1 issue of the journal Health Affairs. “Taken together, these studies show a lot of movement in maternal mental health,” said researcher Stephanie Hall, a postdoctoral fellow at the University of Michigan Medical School. “The landscape is different, at least as far as our health care system’s ability to pick up on conditions and help people get treatment for them.” For the research, investigators analyzed claims data for people with private insurance between 2008 and 2020. They specifically looked for depressive and anxiety disorders occurring during pregnancy or in the first year of motherhood. By 2020, more than one in four (28%) women received a diagnosis of a mood disorder during either pregnancy or the first year of parenthood – a rate nearly double that seen in 2008. Further, the rate of PTSD diagnosis among expecting or new moms quadrupled, rising to nearly 2% of all those pregnant or postpartum in 2020. Fortunately, treatment also appeared to increase alongside diagnoses, researchers said. The rate at which new or expecting moms received talk therapy more than doubled, rising 16% for women diagnosed with anxiety,…  read on >  read on >

The seeds of high blood pressure in adulthood might be sown in youth, a new study suggests. Children and teenagers with excess weight were more likely to have high blood pressure in middle age, researchers report. In fact, there’s a linear relationship between adult high blood pressure and childhood overweight and obesity, researchers found. The heavier a child is, or the more pounds they put on during puberty, the more likely they are to have high blood pressure as an adult, results show. “Our results suggest that preventing overweight and obesity beginning in childhood matters when it comes to achieving a healthy blood pressure in later life,” said lead researcher Lina Lilja, a doctoral student with the University of Gothenburg in Sweden. The World Health Organization estimates that nearly 1.3 billion adults 30 to 79 have high blood pressure, increasing their risk of strokes, heart attacks and kidney disease. High body-mass index in adults is strongly tied to elevated blood pressure, but it’s not clear whether excess weight in childhood contributes to this risk. To learn more, researcher analyzed data on nearly 1,700 Swedish people born between 1948 and 1968.  For these people, BMI readings were taken at age 7 to 8 and again at 18 to 20. Researchers compared this to blood pressure readings, systolic and diastolic, taken among the group at ages 50…  read on >  read on >

Smacking a 100-mile-an-hour fastball or shooting down a fast-moving alien invader in a video game might involve more than fast reflexes, researchers report. Elite gamers and pro athletes may also have a hidden vision advantage over others, a new study finds. Some people can perceive rapidly changing visual cues better than others, researchers reported April 1 in the journal PLOS One. This advantage in eye tracking could explain why some people are better in settings where response time is critical, researchers said. “We don’t yet know how this variation in visual temporal resolution might affect our day-to-day lives, but we believe that individual differences in perception speed might become apparent in high-speed situations where one might need to locate or track fast-moving objects, such as in ball sports, or in situations where visual scenes change rapidly, such as in competitive gaming,” said lead researcher Clinton Haarlem, a doctoral candidate with Trinity College Dublin in Ireland. The rate at which people perceive the world is known as “temporal resolution,” researchers said. Some people effectively see more images per second than others. To quantify this, researchers asked participants to look at a flickering light source. If the light flickered faster than a person’s visual threshold, they saw the light as steady rather than blinking. Some participants saw the light as completely still when it was flashing about…  read on >  read on >

As their aging brains shrink, older dogs can suffer the same memory and thinking problems as many older humans do. But dogs are just like humans in another way — playtime and social activities can help preserve their brain function, a new study finds. Exercising, socializing, playing with toys and playing with other dogs helped a small group of beagles maintain their brains, researchers reported April 1 in the Journal of Neuroscience. Such social enrichment activities particularly helped maintain the size of the beagles’ hippocampus, a brain region tied to memory and emotion that is particularly sensitive to age-related decline, researchers said. Brain scans “showed that total hippocampal volume increased at an average rate of about 1.74% per year across treatment groups, contrasting with the age-related hippocampal volume decline” observed in previous studies, wrote the research team led by senior researcher Craig Stark, a professor of neurobiology at University of California, Irvine. For the study, researchers tracked the brain health of 43 middle-aged beagles, including 36 females and seven males, for three years as part of a study involving two potential drugs for Alzheimer’s disease. The dogs were all 6 years old at the start of the study. All dogs received daily exercise, play with a rotating set of toys and socialization. They also were allowed to play for a half-hour each day in male-only…  read on >  read on >

A new warning is being issued over a heart pump whose use could perforate the heart. The device has already been linked to over 100 injuries and 49 deaths. These left-sided Impella heart pumps are made by Abiomed, a subsidiary of Johnson & Johnson MedTech. Abiomed posted the new warning on the devices on the U.S. Food and Drug Administration’s website. “The FDA has identified this as a Class I recall, the most serious type of recall. Use of these devices may cause serious injuries or death,” the statement said, although it adds that “this recall is a correction, not a product removal.” The advisory informs those implanting the Impella devices about revised instructions for use, including “carefully position the pump catheter during operative procedures.” These Impella pumps resemble a long straw inserted into the heart. They are used during high-risk cardiac procedures (for example, during certain types of heart attack), to help maintain proper blood flow from the heart to the body. The pump is threaded through major heart vessels and into the heart’s left ventricle, the organ’s main pumping chamber. “Abiomed is recalling its Impella Left Sided Blood Pumps because the pump catheter may perforate [cut] the wall of the left ventricle in the heart,” the company warned in its statement. “During operations, the Impella device could cut through the wall of the…  read on >  read on >

For folks who have battled alcohol dependency for years, any treatment that could curb or block alcohol cravings would be a huge advance. Now, research in mice is giving a glimmer of hope that just such a therapy might be possible. A compound — so far dubbed LY2444296 — appears to block a key brain cell receptor called the kappa opioid receptor (KOP), a team at the Scripps Research Institute in California reports. “Compounds designed to selectively block the KOP are very promising because this receptor is involved in a lot of mental illnesses, such as anxiety and depression,” said senior study author Rémi Martin-Fardon, an associate professor of molecular medicine at Scripps. “The KOP system is also important in alcohol use disorder, so the idea is if it’s targeted and blocked, you can stop alcohol abuse,” he explained in a Scripps news release. However, this research has so far only been conducted in mice. Experts are quick to point out that many findings seen in animals are not replicated in humans, and further study is needed. The new study was published recently in the journal Scientific Reports. Martin-Fardon’s team knew that the brain’s “KOP system” helps direct a range of brain responses including addiction, emotion, pain and reward-seeking. Alcohol intake can negatively affect KOP, as well. In the study, the Scripps team tested the…  read on >  read on >

A monthly long-acting injection of buprenorphine can be an easier and more effective therapy for people struggling with opioid addiction, but treatment centers aren’t much interested in using it, a new study discovers. Only one-third of treatment facilities (33%) offer long-acting buprenorphine injections to patients, according to findings published recently in the Journal of the American Medical Association. Researchers suspect this is because substance use treatment centers face administrative obstacles that make it more difficult to offer buprenorphine injections, compared to the daily pill form of the drug. “This paper highlights gaps that exist in the system,” said lead researcher Nitin Vidyasagar, a second-year student at the University of Chicago Pritzker School of Medicine. “We can now use the information to help treat people who need it the most.” Buprenorphine works by activating the same brain receptors that more powerful opioids target. However, the effects are weaker, helping addicts wean themselves off other substances like heroin and fentanyl. Analyzing federal data on substance use, researchers found that primary care doctors are more likely to offer long-acting buprenorphine shots than treatment centers. This might be because doctor’s offices face fewer regulatory and administrative hurdles to prescribe the medication as a monthly injection, the researchers said. “The takeaway is, we still have a lot of work to do to make the full complement of opioid treatment options…  read on >  read on >

Telehealth might be a more effective way of treating alcoholism than in-person therapy sessions, a new study reports. Alcoholics who receive treatment through telehealth were more likely to engage in more therapy visits and stick to anti-alcohol medication longer than those who venture out for alcohol use disorder therapy, researchers found. These results are “particularly important in the current context, as the United States debates whether to sustain or revoke pandemic-era policies that decreased barriers to telehealth,” concluded the research team led by Dr. Ponni Perumalswami, of the VA Ann Arbor Healthcare System. For the study, researchers analyzed data from the Veterans Administration gathered during the pandemic, from March 2020 to February 2021, on more than 138,000 patients diagnosed with alcohol use disorder. During the study period, 53% of patients had at least one video visit, 38% had at least one telephone visit but no video visits, and 9% had only in-person visits, researchers said. Telehealth was associated with more therapy visits and medication use compared with in-person visits, researchers found. What’s more, among those who received treatment through telehealth, video visits prompted significantly more therapy sessions than telephone visits. Black patients were less likely to receive video telehealth treatment and were more likely to have in-person visits, highlighting “important disparities in alcohol use disorder telehealth use,” researchers said. The new study was published recently…  read on >  read on >

Stem cells derived from a patient’s own fat can safely help improve sensation and movement after a spinal cord injury, a new, small study finds. Patients treated with these stem cells experienced increased sensation from pinpricks and light touches, increased muscle strength and better sphincter control, results show. “In spinal cord injury, even a mild improvement can make a significant difference in that patient’s quality of life,” said lead researcher Dr. Mohamad Bydon, a neurosurgeon with the Mayo Clinic. For the study, researchers collected a small amount of fat from the abdomen or thigh of 10 patients with traumatic spinal cord injuries. The patients all had been hurt in car crashes, falls and other traumatic accidents. Six had neck injuries and four had back injuries. Over the course of a month, researchers expanded stem cells derived from the fat until there were more than 100 million cells. They then injected the cells into the patient’s spine in the lower back. Seven of the 10 patients improved as a result of the injections, researchers said. These included two of three patients who started with no feeling or movement below the site of their spinal cord injury, results show. Only 5% of people with a complete spinal injury like that could expect to regain any feeling or movement, researchers noted. This improvement came with no serious side…  read on >  read on >