The former ‘party drug’ ketamine has gotten some good press recently, with clinical trials suggesting it might be a powerful and fast-acting antidepressant. Now, one of the first “real-world” studies of ketamine against depression appears to support those findings. Researchers at the University of Michigan and the VA Ann Arbor Healthcare System say that almost half of 215 veterans who’d been suffering severe, treatment-resistant depression benefited from six weeks of ketamine infusions. “It’s not a silver bullet,” stressed study lead author Dr. Paul Pfeiffer. “But when we see these patients in our clinic, who have been through every treatment available and nothing has worked, to have even a quarter achieve a significant measurable response is very good. We routinely get thanked for making a difference in their lives.” Pfeiffer led the study with Dr. Avinash Hosanagar. Both are faculty at the U-M Medical School department of psychiatry, and both treat patients in the VA Ann Arbor Healthcare System. The veterans involved in the new study were selected because they’d all tried and failed multiple treatments to curb their severe depression. Many had other mental health issues, such as post-traumatic stress disorder (PTSD), anxiety or a history of alcohol or drug abuse. The Michigan researchers had each of the patients receive ketamine infusions beginning in 2019 or the first nine months of 2020. Their outcomes were tracked… read on > read on >
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Is Money Needed for Happiness? Tribes Study Suggests Otherwise
They say money can’t buy happiness – and now a new study of Indigenous peoples around the world backs up that assertion. People living in small-scale societies on the fringes of the modern world lead lives as happy and satisfying as folks from wealthy, technologically advanced nations, researchers report Feb. 5 in the Proceedings of the National Academy of Sciences. “Surprisingly, many populations with very low monetary incomes report very high average levels of life satisfaction, with scores similar to those in wealthy countries,” said lead researcher Eric Galbraith, a professor with McGill University in Montreal. This runs counter to the notion that economic growth is a sure-fire way to increase the well-being of people in low-income countries, researchers noted. Global surveys have found that people in wealthier countries tend to report higher levels of life satisfaction than those in poorer countries, researchers said in background notes. However, these global polls tend to overlook people in societies where the exchange of money plays a minimal role in everyday life, and where livelihoods depend directly on nature, researchers said. For this study, researchers surveyed nearly 3,000 people from Indigenous or primitive communities at 19 sites around the world. Only 64% of the surveyed households had any cash, researchers said. And yet, their average life satisfaction scores were 6.8 on a 10-point scale across all communities, and… read on > read on >
Diagnosed With Macular Degeneration? Here’s What You Need to Know
Age-related macular degeneration can lead to vision loss in seniors, but new therapies have offered fresh hope for preserving eyesight later in life, eye experts say. These cutting-edge therapies benefit both the dry and wet types of age-related macular degeneration (AMD), says the American Society of Retina Specialists (ASRS). Eleven million people in the United States have AMD, with dry AMD affecting about 85% and wet AMD striking 15%. “Patients often tell me they are sure they will lose their vision because they have a family member who experienced vision loss from AMD, but with early diagnosis and treatment, we now have much more than hope to offer patients with wet or dry AMD,” ASRS Foundation President Dr. Judy Kim said in a news release. The macula is a round area at the center of the retina, which is the layer of light-sensitive cells at the back of the eyeball that capture images. People with AMD slowly begin to lose their central vision, according to the American Academy of Ophthalmology. They can’t see fine details either up close or far away, but their peripheral vision remains normal. The AAO gives the example of looking at a clock with hands. People with AMD might see the clock’s numbers, but not the hands. Most patients have early or intermediate dry AMD, which can remain stable for a… read on > read on >
Healthy Living Builds ‘Cognitive Reserve’ in Brain That May Prevent Dementia
New research suggests healthy lifestyles can help stave off dementia, perhaps by building a resilient ‘cognitive reserve’ in the aging brain. The study was based on the brain autopsies on 586 people who lived to an average age of almost 91. Researchers compared each person’s lifestyle and end-of-life mental skills to their neurological signs of dementia, such as brain protein plaques or changes in brain blood flow. None of these brain factors seemed to greatly affect the positive connection between healthy living and a person’s end-of-live mental skills, said a team led by Dr. Klodian Dhana, of Rush University Medical Center in Chicago. That means that good nutrition, regular exercise and other factors may instead “provide a cognitive reserve” that buffers against negative changes going on within the brain — allowing older folk to “maintain cognitive abilities” over time, the researchers said. “You can almost sort of cheat the biology a little bit and still not get the symptomatology as early” as someone who’s less healthy, said Dr. Liron Sinvani, who wasn’t involved in the study. She directs geriatric hospitalist services at Northwell Health in Uniondale, N.Y. The study was published Feb. 5 in the journal JAMA Neurology. As Dhana’s group notes, it’s long been known that certain lifestyle choices — eating well, exercising, avoiding smoking and heavy drinking — are linked to lower rates… read on > read on >
Black Americans Lose Sleep After High-Profile Police Killings
Police killings of unarmed Black people are robbing the Black community of a precious commodity – sleep. Black adults across the United States suffer from sleep problems after they’re exposed to news of killings that occur during police encounters, a new study published Feb. 5 in the journal JAMA Internal Medicine finds. Specifically, Black adults experienced increases in short sleep, lasting fewer than seven hours a night, and very short sleep of less than six hours nightly. “These findings show that poor sleep health is another unfortunate byproduct of exposure to these tragic occurrences,” said lead researcher Dr. Atheendar Venkataramani, an associate professor of medical ethics and health policy at the University of Pennsylvania’s Perelman School of Medicine in Philadelphia. “Exposure of Black Americans to police violence — which disproportionately effects Black individuals — adversely impacts sleep health of these individuals, a critical keystone that further impacts our mental, physical and emotional well-being,” Venkataramani added in a university news release. For the study, researchers analyzed changes in sleep duration tracked by two separate federal surveys, and tied those changes to data on officer-involved killings around the nation. Results showed that about 46% of Black adults reported short sleep versus 33% of white respondents. For very short sleep, the numbers were 18.4% for Black adults and 10.4% for whites. Researchers speculated that awareness of the deaths… read on > read on >
Hearing Troubles Can Affect the Mind, Too
If you’re over 65, you likely struggle sometimes to hear conversations clearly, but ignoring that may prompt even more serious health problems, experts say. If left unchecked, hearing loss can lead to social isolation and depression — two conditions known to raise dementia risk, said Dr. Leah Ross, a physician in the Division of Geriatric Medicine at Penn State Health’s Milton S. Hershey Medical Center. Hearing impairment is the third most common chronic condition faced by older adults, Ross said. Yet, only 20% of these folks have had a hearing test in the past five years, according to the American Speech-Language-Hearing Association. While more than half of adults acknowledge they struggle with hearing problems, only 11% have sought treatment. “A lot of times, people are suffering with hearing impairment for years before they even say anything to their doctors,” Ross noted in a Penn State news release. The good news? “It is a modifiable risk factor,” Ross said. “There’s something we can do about it.” What’s missed by not treating hearing loss is what it can trigger, Ross explained. In her practice, she often sees this familiar scenario: An older adult with hearing loss discovers his or her hearing has declined to the point where they have trouble understanding conversations. They start to skip social events and stay at home, as their world shrinks and… read on > read on >
Shark Bites Are Up Worldwide
Unprovoked shark attacks increased slightly worldwide last year, but twice as many people died from shark bites as the year before, new data show. There were 69 unprovoked shark attacks in 2023, higher than the five-year average of 63 attacks per year, according to the University of Florida’s International Shark Attack File. Ten of the attacks in 2023 proved fatal, up from five the year before, researchers said. “This is within the range of the normal number of bites, though the fatalities are a bit unnerving this year,” said Gavin Naylor, director of the Florida Museum of Natural History’s shark research program. Australia suffered a disproportionate number of shark bite deaths, the researchers noted. The continent accounted for 22% of all attacks but made up 40% of fatalities. Other shark attack deaths occurred in the United States, the Bahamas, Egypt, Mexico and New Caledonia, researchers said. The United States had 36 unprovoked shark attacks, accounting for 52% of incidents worldwide. Of those, two attacks were fatal, one in California and another in Hawaii. As has been the case in previous years, Florida had more shark bites than any other state, with 16 attacks. Confirmed non-fatal bites also happened in Costa Rica, Colombia, Brazil, New Zealand, Seychelles, Turks and Caicos, Ecuador and South Africa. This annual report focuses primarily on unprovoked attacks, although the database documents all… read on > read on >
Weight-Loss Med Zepbound Lowers High Blood Pressure in Obese People
The weight-loss drug Zepbound provides more health benefits than dropping pounds and controlling diabetes, a new study shows. It also appears to help people with obesity manage their high blood pressure, results show. Patients taking Zepbound (tirzepatide) experienced a significant reduction in their systolic blood pressure, the top number in a blood pressure reading, according to a study published Feb. 5 in the journal Hypertension. Systolic blood pressure is a stronger predictor for heart-related death than the diastolic bottom number, researchers said in background notes. “Although tirzepatide has been studied as a weight-loss medication, the blood pressure reduction in our patients in this study was impressive,” said lead researcher Dr. James de Lemos, chair of cardiology at UT Southwestern Medical Center in Dallas. Tirzepatide works by mimicking two hormones in the body that stimulate insulin secretion and sensitivity after a person eats. The drug helps slow down digestion, reduce appetite and regulate blood sugar levels. For the study, 600 adults with obesity were assigned to take either a placebo or varying doses of tirzepatide, which is administered through injection. After 36 weeks, results showed that: Participants taking 5 mg of tirzepatide had an average systolic blood pressure reduction of 7.4 mm Hg People taking 10 mg had an average systolic blood pressure reduction of 10.6 mm Hg Participants taking 15 mg had an average systolic… read on > read on >
FDA Panel Tackles Faulty Pulse Oximeter Readings That Come With Darker Skin
A U.S. Food and Drug Administration advisory panel on Friday addressed a continuing issue with pulse oximeters — that they give less accurate readings for folks with darker skin. The devices are designed to measure oxygen levels in the blood, so correct readings are critical, experts say. During its daylong meeting, the FDA’s Anesthesiology and Respiratory Therapy Devices Panel reviewed ways to better evaluate the accuracy of pulse oximeters in patients with darker skin. Although there is more work to be done when it comes to making pulse oximeters more accurate, panel member Dr. Jeffrey Feldman said the devices’ benefits of these devices still outweigh their limitations. “This technology has and continues to save lives on a daily basis in this country. … It needs to be improved. We need to look at health disparities, and we need to do better,” he said after the meeting, CNN reported. “But we also need to recognize how valuable this technology is for patients every day, at home and in the hospital.” Precisely because the general public can use these devices at home to check their oxygen levels, the panel honed in on how to ensure the accuracy of pulse oximeters for all skin tones before they reach drugstore shelves. So, the panel focused on the structure of company trials testing the products. Back in 2013, the FDA issued premarket guidance for… read on > read on >
Need Mental Health Services Via Telehealth? Many Clinics Still Don’t Offer It
Accessing mental health care via telehealth boomed during the pandemic, and it continues to be a valuable resource for patients. However, it could still be tough to find, depending on the clinics available in your area, new research finds. “We found considerable variation in the types of services telehealth offered by mental health clinics across the U.S.,” said study author Jonathan Cantor, a policy researcher at RAND Corp., a nonprofit research organization. His team published its findings, based on a “secret shopper” study, in the Feb. 2 issue of JAMA Health Forum. Between late 2022 and March 2023, Cantor and his colleagues tried phoning more than 1,900 outpatient mental health treatment facilities treating adults across the United States. For more than 500 clinics called, the researchers failed to reach anyone. “The fact that we could not reach anyone at one in five facilities suggests that many people may have trouble reaching a clinic to inquire about mental health care,” Cantor noted in a RAND news release. Of the remaining 1,404 clinics that did have someone respond to the “secret shopper” queries, 87% said they were accepting new patients and 80% said they offered telehealth services. Those services varied in terms of how they were offered. For example, about half of clinics offering telehealth said it was available via video appointments only, 5% said it was… read on > read on >