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How much a person believes in the strength of a drug might influence how powerfully that drug influences brain activity, a new study has found. Smokers told to expect a low, medium or high dose of nicotine from an e-cigarette showed a brain response that tracked with the purported dose, even though nicotine levels were actually constant, researchers said. “We set out to investigate if human beliefs can modulate brain activities in a dose-dependent manner similar to what drugs do, and found a high level of precision in how beliefs can influence the human brain,” said senior researcher Xiaosi Gu. She’s an associate professor of psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai, in New York City. For the study, Gu and her team recruited a group of people hooked on nicotine and had them puff on an e-cigarette, after telling them how powerful a nicotine dose they should expect. The participants then underwent brain scans while performing a decision-making task known to engage parts of the brain affected by nicotine. “Beliefs can have a powerful influence on our behavior, yet their effects are considered imprecise and rarely examined by quantitative neuroscience methods,” Gu noted in a Mount Sinai news release. The thalamus — an important binding site for nicotine in the brain — showed a dose-dependent response to each person’s… read on > read on >

Migraines are not only extremely painful, but they also appear to pose a driving risk for seniors, a new study warns. Older adult drivers recently diagnosed with migraines are three times more likely to be involved in a car crash, researchers reported recently in the Journal of the American Geriatrics Society. “Migraine headaches affect more than 7% of U.S. adults over the age of 60,” noted lead researcher Dr. Carolyn DiGuiseppi, a professor with the University of Colorado School of Public Health. “The U.S. population is aging, which means increasing numbers of older adult drivers could see their driving abilities affected by migraine symptoms previously not experienced,” DiGuiseppi added in a university news release. “These symptoms include sleepiness, decreased concentration, dizziness, debilitating head pain and more.” For the study, researchers tracked more than 2,500 drivers ages 65 to 79 in five sites across the United States. A previous diagnosis of migraine did not appear to influence a driver’s crash risk, results show. But a new migraine diagnosis brought with it a threefold increase in the risk of a wreck within a year, researchers found. Medications commonly prescribed for migraines did not appear to influence either crash risk or driving habits, the researchers noted. “These results have potential implications for the safety of older patients that should be addressed,” DiGuiseppi said. “Patients with a new migraine… read on > read on >

Drugs already used by millions to lower cholesterol might someday have a new role: Relieving asthma and COPD. That’s the hope of a new line of research underway at the University of California, Davis. A study funded by the U.S. National Institutes of Health is seeking to determine whether a “statin inhaler” might reduce the airway inflammation that makes breathing difficult for folks with illnesses like asthma or chronic obstructive pulmonary disease (COPD). Taking a statin pill has no significant effect on the airways, but “delivering statins directly to the lung via inhalation might achieve better local tissue drug levels, and therefore, better clinical results,” theorized lead investigator Amir Zeki, a professor of internal medicine who specializes in pulmonary, critical care and sleep medicine at UC Davis. This research is still in its early stages. However, if it pans out it might offer another treatment option to the more than 26.5 million Americans with asthma and the more than 16 million battling COPD. Zeki’s team is focusing on what’s known as airway smooth muscle (ASM) — tissue which lies within each airway’s wall and helps control airflow. The inflammation that drives asthma can trigger a tightening of smooth muscle, restricting airways. This “hyperactivity” of smooth muscle also plays a role in COPD, the researchers explained. Treatments such as asthma bronchodilators already target receptors on specific… read on > read on >

People who are early risers appear to be at greater risk of developing anorexia, a new study claims. This differs from other disorders like depression, binge eating and schizophrenia, all of which appear to be associated with folks being “night owls,” the researchers noted. “Our findings implicate anorexia nervosa as a morning disorder in contrast to most other evening-based psychiatric diseases and support the association between anorexia nervosa and insomnia as seen in earlier studies,” said senior study author Hassan Dashti, an assistant investigator in Massachusetts General Hospital’s Department of Anesthesia, Critical Care and Pain Medicine in Boston. Previous research has suggested a link between eating disorders and the internal clock of the human body, which controls sleep cycles and affects nearly every organ in the body, researchers said in background notes. For this study, the team examined genes specifically associated with anorexia, looking to see whether people with a higher genetic risk for the disorder also tended to have a specific sleep cycle. The team discovered a two-way association between genes linked to anorexia and genes associated with waking early and going to bed early. Having anorexia could lead a person to be an early bird, and an earlier wake time could mean a person is at higher risk of anorexia. An elevated genetic risk score for anorexia was also associated with a higher… read on > read on >

The U.S. Food and Drug Administration is investigating reports of additional dangers linked to several wildly popular weight-loss drugs. In a quarterly report issued this week, the agency said it is investigating cases of hair loss; aspiration (when food or other objects get into the airways); and suicidal ideation in people who used the medications. Some of the drugs in this class, known as GLP-1 receptor agonists (GLP-1 RA), include Ozempic, Wegovy, Mounjaro and Zepbound. While these reports can turn out to be false alarms, previous investigations have prompted the FDA to update a drug’s labeling or call for additional study on the issue. This isn’t the first time the agency has looked into potential complications with these weight-loss drugs: Last year, the agency investigated reports of intestinal obstructions linked to the medications. Ozempic’s labeling was subsequently updated to acknowledge that risk, CBS News reported. “We are aware that, as part of those monitoring efforts, [the] FDA is evaluating several potential signals related to GLP-1 RA medicines and has posted information about those ongoing assessments on its website,” a spokesperson for Novo Nordisk, which makes Ozempic and Wegovy, told CBS News. “Novo Nordisk stands behind the safety and efficacy of all of our GLP-1 RA medicines when they are used as indicated and when they are taken under the care of a licensed healthcare professional,” the spokesperson added.… read on > read on >

An electrical zap to the brain can temporarily render a person more susceptible to hypnosis, a new study shows. Participants became more easily hypnotized after paddles placed against their scalp delivered two 46-second rounds of electrical pulses to a precise location in their brain, researchers reported Jan. 4 in the journal Nature Mental Health. This increase in their susceptibility to hypnosis lasted for about an hour, results show. These findings could make hypnotherapy a viable treatment for people who otherwise couldn’t be deeply tranced, the researchers said. “We know hypnosis is an effective treatment for many different symptoms and disorders, in particular pain,” said lead researcher Afik Faerman, a postdoctoral scholar in psychiatry at Stanford Medicine. “But we also know that not everyone benefits equally from hypnosis.” About two-thirds of adults are at least somewhat prone to hypnosis, and 15% are considered highly hypnotizable, researchers said in background notes. “Hypnosis is a state of highly focused attention, and higher hypnotizability improves the odds of your doing better with techniques using hypnosis,” senior researcher Dr. David Spiegel, a professor of psychiatry and behavioral sciences at Stanford, said in a university news release. Spiegel has studied hypnotherapy for decades, using it to help patients control pain, lower stress and stop smoking. Up to now, hypnotizability has seemed to be a stable trait in people that changes little… read on > read on >

A tasty vegetarian salad could be the fresh meal that fuels a space flight to Mars, a new study contends. Researchers came up with the salad while searching for the optimal “space meal” that would supplement prepackaged foods on long voyages between planets. The salad contains soybeans, poppy seeds, barley, kale, peanuts, sweet potato, and sunflower seeds, according to a report in the journal ACS Food Science & Technology. These ingredients meet male astronauts’ special nutritional needs and can be grown in space, the researchers said. Astronauts in space burn more calories than humans on Earth do, researchers said in background notes. They also require extra nutrients like calcium to stay healthy during extended periods of weightlessness. Previous efforts have explored ways to grow food in space, but no specific fresh meals have been developed for future space travel, noted senior researcher Volker Hessel, a professor of sustainable chemical engineering at the University of Adelaide in Australia. For this study, researchers assessed combinations of fresh ingredients that could be grown in space because they require less water, fertilizer, time and area. They also considered whether inedible portions of the grown foods could be recycled onboard a spaceship. After settling on their space salad, the researchers whipped one up and subjected it to an Earthbound taste test for four people. One tester raved about the salad,… read on > read on >

Some people might be prone to low back pain because of specific cells contained in their spinal disks, a new study suggests. The research could explain why only certain people develop back pain due to the degeneration of their spinal discs, which are jelly-filled spacers that act as shock absorbers between the small bones of the vertebrae. “We’ve identified for the first time particular cells that could be the key to understanding disk pain,” said senior study author Dmitriy Sheyn, a research scientist in the Board of Governors Regenerative Medicine Institute at Cedars-Sinai Medical Center in Los Angeles. “Learning more about how these cells work could lead to the eventual discovery of new treatment options,” Sheyn added in a Cedars Sinai news release. About 40% of adults experience low back pain due to degenerating disks in the spine, but up to now it’s not been clear exactly why the disks become painful. The jelly in spinal disks tends to dry out and degenerate as people age, but that doesn’t automatically trigger back pain, the researchers noted. “This is because the inner jelly-like layers of the disks contain no nerve endings,” Sheyn said. “But sometimes, when disks degenerate, nerve endings from the surrounding tissues invade the disk, and we believe this causes pain.” For this study, researchers first compared spinal disks from patients with low back… read on > read on >

You may think that artificial sweeteners can help you lose some weight, but a new study finds they are no good for your gut’s microbiome. People who use aspartame (Equal), sucralose (Splenda), saccharin (Sweet’N Low), or stevia leaf extract tended to have intestinal bacteria colonies that differed significantly from those of people who didn’t use sugar substitutes, researchers found. They had less rich colonies of bacteria in their small intestines or, even worse, higher levels of bacteria that churn out harmful toxins. “Artificial sweeteners are not benign for the microbiome of the gut,” said study author Dr. Ruchi Mathur, a professor and endocrinologist with Cedars-Sinai Medical Center in Los Angeles. More than 140 million Americans use artificial sweeteners to lower their sugar intake, researchers said in background notes. However, concerns have been raised that sugar substitutes don’t help with long-term weight loss and might be tied to increased risk of type 2 diabetes and heart disease, researchers said. The gut microbiome plays a key role in a person’s health, and diet can influence the makeup of these bacteria in significant ways. So, in a controlled study, researchers analyzed the microbial diversity of the small intestines in people who used artificial sweeteners, including nine who used aspartame and 35 who used other sugar substitutes. They compared the gut microbiome of those patients to a group of… read on > read on >

A diet laden with omega-3 fatty acids found in nuts and oily fish might help slow the progression of pulmonary fibrosis, researchers report. Pulmonary fibrosis is a relentless, potentially fatal disease where lung tissue scars and hardens over time. Often tied to smoking, the illness impairs lung function so that patients become short of breath, weak and disabled. The new study was led by Dr. John Kim, a pulmonary and critical care expert at the University of Virginia School of Medicine and UVA Health, in Charlottesville. His team tracked the health of 300 patients with interstitial lung disease — the class of respiratory ailments that includes pulmonary fibrosis. Most had “idiopathic” pulmonary fibrosis (meaning the exact cause of the illness is unknown) and most were men (males are more prone to the disease). Blood tests were taken to gauge each patient’s dietary intake of omega-3 fatty acids. The team found that “higher levels of omega-3 fatty acids were predictive of better clinical outcomes in pulmonary fibrosis,” Kim said in a university news release. Specifically, people with higher levels of the nutrient had lungs that were better able to exchange carbon dioxide and oxygen — a process necessary to life. They also were better able to survive without needing a lung transplant, the study found. “These findings were consistent whether [or not] you had a history of… read on > read on >

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All Sauce from Weekly Gravy:

Nicotine Study Shows Mind’s Power When It Comes to Drugs

Migraines Could Raise Crash Risks for Older Drivers

Could Inhaling a Statin Help Ease Asthma, COPD?

Could ‘Early Birds’ Be at Higher Risk for Anorexia?

FDA Looking Into New Risks With Popular Weight-Loss Drugs

Brain Zaps Can Make Folks More ‘Hypnotizable’

Here’s the Ideal Salad for Men on Long Spaceflights

New Clues To Origins of Lower Back Pain

Could Artificial Sweeteners Alter Your Microbiome?

Healthy Omega-3 Fatty Acids Could Slow a Deadly Lung Disease