Weekly Gravy « Weekly Gravy

All Sauce from Weekly Gravy:

THURSDAY, Sept. 28, 2023 (HealthDay News) – An advisory panel to the U.S. Food and Drug Administration on Wednesday voted resoundingly against recommending a stem cell-based experimental treatment for ALS. Although the FDA isn’t bound by the votes of its advisory panels, agency scientists have already penned a scathing review of the drug, called NuOwn. The application from Brainstorm, the company that developed the treatment, was “scientifically incomplete” and “grossly deficient,” FDA staff scientists wrote in the review. Meanwhile, the advisory panel voted 17-1 against the drug to treat amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. Only a panelist representing patients voted for the medication, while one adviser abstained from voting, the Associated Press reported. “Creating false hope can be considered a moral injury and the use of statistical magic or manipulation to provide false hope is problematic,” Lisa Lee, a bioethics and research integrity expert from Virginia Tech who voted against the treatment said, the AP reported. ALS is typically fatal within three to five years of a patient’s first symptoms, as the condition destroys nerve cells in the brain and spinal cord, taking away the ability to walk, talk, swallow and breathe. The FDA agreed to convene the advisory panel in response to a 30,000-signature petition from ALS patients and advocates. But a study from Brainstorm involving 200 patients did… read on > read on >

Smoking during pregnancy is a significant risk factor for premature births, but drinking coffee is not, new research suggests. Women who smoked during pregnancy were 2.6 times more likely to give birth prematurely compared to nonsmokers, a risk that was double that of previous estimates, the University of Cambridge scientists found. “We’ve known for a long time that smoking during pregnancy is not good for the baby, but our study shows that it’s potentially much worse than previously thought. It puts the baby at risk of potentially serious complications from growing too slowly in the womb or from being born too soon,” said Gordon Smith, head of the department of obstetrics and gynecology at Cambridge, in the United Kingdom. The study also showed that with prenatal smoking, a baby was four times more likely to be small for its gestational age. This brings the risk of potentially serious complications, including breathing difficulties and infections. On the other hand, high caffeine intake from coffee or other drinks did not have the same effect, even though it’s been shown previously to be associated with lower birth weights and possibly fetal growth restriction. In this study, scientists measured levels of chemical byproducts created when substances such as tobacco and caffeine are processed in the body. The investigators recruited more than 4,200 women who attended the Rosie Hospital, part… read on > read on >

Adding 3,000 extra steps a day can help older adults with hypertension significantly lower their blood pressure. About 80% of older adults in the United States have high blood pressure. Keeping it down can help protect against heart failure, heart attacks and strokes. “We’ll all get high blood pressure if we live long enough, at least in this country,” Linda Pescatello, professor of kinesiology at the University of Connecticut, said in a university news release. “That’s how prevalent it is.” While her previous research had shown that exercise could have an immediate and long-lasting impact on blood pressure, this new study set out to learn whether moderately increasing walking — popular in this age group — could do the same. “It’s easy to do, they don’t need any equipment, they can do it anywhere at almost any time,” said co-author Duck-Chul Lee, a professor of kinesiology at Iowa State University. The researchers focused on a group of sedentary 68- to 78-year-olds who walked about 4,000 steps per day. By adding in 3,000 steps, they would log 7,000 daily steps, in line with a recommendation of the American College of Sports Medicine. Getting “3,000 steps is large enough but not too challenging to achieve for health benefits,” Lee said in the release. Participants received kits with pedometers, blood pressure monitors and step diaries to track their… read on > read on >

A new study suggests there may be a link between job loss and miscarriage or stillbirth. The risk of miscarriage or stillbirth doubled after a pregnant woman or her partner lost a job, European researchers found. Their study was published Sept. 28 in the journal Human Reproduction. “Further research would need to be carried out to understand if losing one’s job actually causes the increased risk of pregnancy loss,” said author Selin Köksal, senior research officer at the University of Essex Institute for Social and Economic Research in England. She said it would be helpful to look at different socioeconomic groups to assess exactly how a job loss relates to higher risk of a miscarriage or a stillbirth. “Is it because of economic hardship, or an experience of an unexpected event or is it due to loss of social status?” Köksal said in a journal news release. “These are the questions that I am hoping to answer in the future.” For this study, the researchers used data from a survey of 40,000 U.K. households conducted between 2009 and 2022. The data included more than 8,000 pregnancies for which there was information on date of conception and outcome. Overall, 11.6% ended in miscarriage, though the number is likely higher because many pregnancies are lost before women realize they’re expecting. Researchers also found 38 stillbirths, representing 0.5%… read on > read on >

Ozempic, a type 2 diabetes drug that has increasingly been used to help with weight loss, will now be labeled as having the potential to block intestines. The U.S. Food and Drug Administration recently made the label update for the drug made by Novo Nordisk, without directly citing Ozempic as the cause for this condition. “Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure,” the label reads. The side effect, known by the medical term “ileus,” is also listed on labels for the weight-loss drug Wegovy, also made by Novo Nordisk, and in the diabetes medication Mounjaro, made by Eli Lilly, CBS News reported. Both Ozempic and Wegovy are known generically as semaglutide. Among more than 8,500 reports of gastrointestinal disorders after using semaglutide medications through June 30, ileus is mentioned in 33 cases, including two deaths, CBS News reported. The two pharmaceutical companies that make these medications are both being sued for claims that the drugs can cause a similar health issue known as gastroparesis, or stomach paralysis, CBS News reported. More information The U.S. National Library of Medicine has more on ileus. SOURCE: CBS News read on >

A newer understanding of multiple sclerosis (MS) suggests that psychiatric conditions like anxiety and depression may emerge long before classic MS symptoms. “For a long time, it was thought that MS only really began clinically when a person experienced their first demyelinating event, such as in the form of vision problems,” said senior author Helen Tremlett. She is a professor of neurology at the University of British Columbia’s Djavad Mowafaghian Center for Brain Health, in Vancouver. “But we’ve come to understand there is a whole period preceding those events where the disease presents itself in more indirect ways,” Tremlett said in a university news release. The findings were welcomed by Sharon Roman, an MS patient for 25 years. “We take many things in life for granted — walking, balance, vision, speech, even the simple act of swallowing — until one day it’s taken from us by MS,” Roman said in the news release. “The better we can identify the early signs and symptoms of MS, the earlier we can recognize, diagnose and treat it. We can help prevent people from being diagnosed the way I was, with a massive attack and hospitalization, and prevent the losses I’ve experienced. Earlier treatment may help slow progression.” MS is an autoimmune disorder with varied symptoms that can make it harder to diagnose and more easily confused with other… read on > read on >

Suffering from PTSD may take a toll on your sex life if you’re a woman, new research reveals. About 10% of women have PTSD symptoms because of combat exposure, childhood abuse and sexual violence. Little research has been done looking at how these symptoms might affect sexual functioning among midlife women. “As women age, there are many reasons why sexual functioning may become an issue for them,” said Dr. Stephanie Faubion, medical director for the North American Menopause Society. “This study highlights the need for health care professionals to ask about any history of trauma and open up the dialogue with their patients on this sensitive issue,” she said in a society news release. Researchers studied this in more than 100 postmenopausal women ages 45 to 66. The authors accounted for factors such as age, race/ethnicity, education, vaginal estrogen use, alcohol use and depressive symptoms. Study participants needed to have met certain criteria — they had to have experienced PTSD symptoms and had sexual activity within the month prior to evaluation. On average, women who reported moderate and severe PTSD symptoms also reported lower sexual functioning. The authors then considered specific aspects of PTSD symptoms. They found that greater avoidance/numbing symptoms were related to poorer sexual functioning. The results will be presented Wednesday during the Menopause Society’s annual meeting, in Philadelphia. Findings presented at medical… read on > read on >

Nurses, health technicians and health care support workers face a higher risk of suicide than the general U.S. population does, an alarming new study shows. Researchers pointed out these workers have to perform stressful tasks while caring for ill patients and managing heavy workloads, with little control over patient outcomes. Not only that, but “health care workers’ relationship roles are often characterized as having a kind of a high achievement and a perfectionistic or compulsive personality traits that can make them excessively devoted to their work and have trouble taking time off,” said study first author Dr. Mark Olfson, a professor in Columbia University’s Department of Psychiatry. “And all of this can contribute to poor self-care and delay them recognizing a need for help. There’s also a lot of stigma that continues just around mental health care.” The study, published Sept. 26 in the Journal of the American Medical Association,, looked at a nationally representative group of more than 1.8 million adults ages 26 and older in data that spanned from 2008 through 2019. Health care workers were divided into six groups — physicians, registered nurses, other health care-diagnosing or treating practitioners, health technicians, health care support workers, and social/behavioral health workers — and compared them with non-health care workers. Analysis of the data showed that health care support workers, registered nurses and health technicians… read on > read on >

Heart failure can make everyday activities and exercise tough to carry out, but yoga might be a beneficial add-on to standard care. A new study from India finds this ancient practice improves quality of life and cardio functioning. “Our patients observed improvement in systolic blood pressure and heart rate compared to patients who were on medication without yoga,” said lead study author Ajit Singh, a research scientist at Manipal Academy of Higher Education. (Systolic blood pressure is the first number in a blood pressure reading.) In heart failure, the heart muscle is either too weak or too stiff to pump properly. This can lead to fluid buildup, shortness of breath and other complications. How might yoga help? “Yoga is a combination of mind-body techniques, which is a set of physical exercises [asana] with breathing techniques [pranayama], relaxation and meditation that can be effectively used to stimulate physical and mental well-being,” Singh explained in an American College of Cardiology news release. For the study, the researchers enrolled 75 heart failure patients between the ages of 30 and 70 at a care center in South India. They had received recommended therapy for the previous six months to one year. Each had what’s called left ventricular ejection fraction (LVEF) of less than 45%, a sign of mild to moderate dysfunction, according to the U.S. National Institutes of Health.… read on > read on >

TUESDAY, Sept. 26, 2023 (HealthDay News) – The lax enforcement of age limits by many online marijuana dispensaries makes it easier for minors to buy weed, claims new research that looked at online weed sales in 32 states. “It is imperative to require strict age-verification procedures prior to cannabis purchases online and to establish stringent surveillance of online marijuana dispensaries to protect youth,” wrote the authors of the new study, published Monday in the journal JAMA Pediatrics. The authors looked at age-verification policies and other practices of 80 online dispensaries. About 18.8% of dispensaries “required no formal age verification at any stage of the purchasing process,” according to the study. Meanwhile, more than 80% accepted “non-traceable” payment methods such as pre-paid cards or cash. These polices are “enabling youth to hide their transactions,” the authors noted. The issue, in addition to the law, is about what impact marijuana has on the developing brain, especially as potency of products has increased, the researchers noted. The pandemic saw a drop in marijuana use by minors, possibly because it was harder to get and use the drugs without notice, the New York Times reported. The new study also found that nearly one-third of online dispensaries allowed delivery across state lines. Among those that did, 95% would deliver to states that had different laws than the states they were… read on > read on >

Weekly Gravy

Look Good – Feel Good – Feed Good

A little about: Weekly Gravy

All Sauce from Weekly Gravy:

FDA Panel Says No to Experimental ALS Drug

Coffee Won’t Raise Preemie Birth Risk, But Smoking Certainly Will: Study

Adding Just 3,000 Steps Per Day Could Lower High Blood Pressure

Job Loss Within Couples Ups Odds for Miscarriage, Stillbirth

FDA Adds Warning to Ozempic Label About Risk for Blocked Intestines

Emotional Issues Could Be Early Sign of MS

PTSD Can Harm a Woman’s Sex Life

Nurses, Health Care Staff Face Higher Suicide Risks

Strike a Pose: Yoga Helps Heart Failure Patients

Buying Marijuana Online Easy for Minors, Study Finds