Another experimental drug meant for Alzheimer’s disease looks so promising that drugmaker Eli Lilly plans to ask the U.S. Food and Drug Administration for full approval by the end of June. Known as donanemab, the medication clears amyloid plaque from the brain. In a late trial, the drug slowed memory and thinking declines in early symptomatic Alzheimer’s patients by more than a third, Lilly said Wednesday. About 47% of those taking the medication had no decline on a key measure of thinking over a year, compared to 29% of patients on a placebo. “We are extremely pleased that donanemab yielded positive clinical results with compelling statistical significance for people with Alzheimer’s disease in this trial,” Dr. Daniel Skovronsky, Lilly’s chief scientific and medical officer and president of Lilly Research Laboratories, said in a company news release. “This is the first Phase 3 trial of any investigational medicine for Alzheimer’s disease to deliver 35% slowing of clinical and functional decline.” But there were some risks noted in the results. The Lilly trial involved 1,700 patients, three of whom died during the study. Two of those deaths were attributed to brain swelling or microbleeds called amyloid-related imaging abnormalities (ARIA). “We are encouraged by the potential clinical benefits that donanemab may provide, although like many effective treatments for debilitating and fatal diseases, there are associated risks that may… read on > read on >
A little about: Weekly Gravy
All Sauce from Weekly Gravy:
Among Kids With Autism, Girls Are More Prone to Anxiety Disorders Than Boys
Boys are four times more likely to be diagnosed with autism than girls are, but girls may be more likely to experience anxiety alongside the disorder than boys, new research reveals. Anxiety tends to travel with autism, which is characterized by problems with social interaction, communication and behavior. About 1 in 36 kids in the United States has autism, according to the U.S. Centers for Disease Control and Prevention. Now, this latest study suggests that the developmental disorder might play out a bit differently in girls. “Autistic females have higher rates of anxiety disorders than autistic males, especially in presentations of anxiety that are distinct to autism and may be more challenging to identify,” said study author Christine Wu Nordahl, director of the Autism Phenome Project. “This is especially important because we now know that there are effective treatments for anxiety in autistic youth that can greatly improve their quality of life, but the promise of effective treatments …can only be realized if we can accurately identify anxiety,” she added. For the study, 112 kids with autism (89 boys and 23 girls) underwent brain scans when they were toddlers and at three other time points. Their parents were interviewed about their anxiety symptoms when these kids were 9 to 11 years old, to help tease out whether anxiety was related to autism symptoms or a… read on > read on >
Mindfulness Approach Helps Ease the Stress of Parenting a Child With Autism
“Mindfulness” practices may help parents of young children with autism manage their daily stressors, and it could benefit their kids in the process, a preliminary study suggests. Parenting is stressful, and studies show that parents of kids with autism often have particularly high stress levels. Autism is a developmental brain disorder that, to varying degrees, impairs communication and social skills. Some kids have milder difficulties, but others are profoundly affected — speaking little, if at all, and getting wrapped up in repetitive, obsessive behaviors. Some children have intellectual disabilities, while others have average or above-average IQs. There are various therapies and services to help improve daily functioning and quality of life for kids with autism. But they typically do not address parents’ stress and coping skills, said Rachel Fenning, the lead researcher on the new study. Traditionally, she noted, there’s been something of an assumption that services that benefit children with autism will also help ease parents’ stress. But that is not necessarily true, since parents can be dealing with all kinds of challenges, said Fenning, who directs the Claremont Autism Center at Claremont McKenna College, in Claremont, Calif. The stressors can range from problems accessing autism services or learning how to implement a child’s therapy strategies at home, to the bigger-picture issues of balancing work and home life, paying the bills and more. So… read on > read on >
In Survey, Half of U.S. Parents Believe Social Media Is Harming Their Kids
Half of U.S. parents think social media is bad for their kids’ mental health, a new survey reveals. The finding highlights growing concerns about how these platforms affect children’s and adolescents’ well-being, according to the On Our Sleeves Movement for Children’s Mental Health, which had the Harris Poll conduct the survey. The program encourages parents to help their kids by talking regularly about how using social media makes their children feel. While in the past year some platforms like TikTok have introduced new safety measures and lawmakers have talked about limiting access, that’s not enough, the researchers said. “This is a positive step, but parents can’t trust that this is enough,” said Dr. Ariana Hoet, clinical director of On Our Sleeves and a pediatric psychologist at Nationwide Children’s Hospital in Ohio. “Social media has the ability to increase anxiety and depression in children when used inappropriately, as well as potentially open them up to inappropriate sharing, hurtful language, bullying and more.” The survey questioned more than 2,000 U.S. adults, including more than 700 parents of children younger than 18, in late March and early April. The survey found that the number of adults who said social media has a positive impact on children’s mental health fell to just over one-third. It was 43% in 2022. “Be curious about what your child is doing on social… read on > read on >
State Anti-Poverty Programs Help Kids’ Brains Stay Healthy
In U.S. states that provide financial assistance for low-income families, the difference is evident in children’s brains, researchers report. Their study found disparities in brain structure between children from high-income households compared to low-income households. However, the disparity was more than a third lower in states offering greater cash assistance to low-income families, compared to states offering less help. In addition, the disparity in mental health symptoms was reduced by nearly a half. The study, which was funded by the U.S. National Institute on Drug Abuse (NIDA), involved more than 10,000 children ages 9 to 11, using data from the Adolescent Brain Cognitive Development Study (ABCD) study. “The association between brain structure and a low-resource environment is not an inevitability,” said study author David Weissman, a postdoctoral fellow in the Stress and Development Lab at Harvard University. “Children’s brains are undergoing substantial development and have enhanced plasticity or capacity for further change based on their environment,” Weissman said in a NIDA news release. “These data suggest that policies and programs that work to reduce social and health inequities can directly reach children in disadvantaged environments and help support their mental health.” Emerging evidence has shown that children from families with lower income have smaller hippocampal volume than those in families with higher income, the researchers said. The hippocampus is involved in both memory and emotional… read on > read on >
Key to Post-Stroke Recovery: Exercise
Physical activity after a stroke may be crucial to a more successful recovery, according to a study by Swedish researchers. They found that patients who increased and sustained their exercise in the six months after their stroke were functioning better than those who didn’t. “People who have experienced a stroke can gain functional benefits by increasing physical activity, regardless of stroke severity,” said lead researcher Dr. Dongni Buvarp of the Institute of Neuroscience and Physiology at the University of Gothenburg. Men and patients with normal mental abilities were more likely to maintain a steady exercise regimen, regardless of the severity of their stroke, the study found. These findings may spur ways to target people whose physical activity drops in the wake of a stroke, Buvarp said. “This would allow an improvement of functional outcome after stroke,” she said. At least four hours a week of light exercise is the ideal to shoot for after a stroke, Buvarp said. Activities can include riding a bike or walking, gardening, fishing, table tennis or bowling, she suggested. “Engaging in physical activity can enhance both brain and body capacity to aid in stroke recovery,” Buvarp said. “Physical activity promotes brain plasticity and also improves recovery at the cellular level.” She noted that an active lifestyle can boost stroke patients’ mobility and reduce their risk of falls, depression and heart… read on > read on >
U.S. Surgeon General Announces National Plan to Fight ‘Loneliness Epidemic’
U.S. Surgeon General Dr. Vivek Murthy has declared war on what he calls a “loneliness epidemic” in the United States. Murthy announced a “National Strategy to Advance Social Connection” to address this “epidemic of loneliness and isolation.” “In recent years, about one-in-two adults in America reported experiencing loneliness,” Murthy said in an advisory released Monday about the strategy. “And that was before the COVID-19 pandemic cut off so many of us from friends, loved ones and support systems.” Social connection can make communities more resilient, he noted. “Loneliness I think of as a great masquerader. It can look like different things,” Murthy told CNN on Monday. “Some people, they become withdrawn. Others become irritable and angry. … I think the time you get concerned is when you start experiencing a feeling of loneliness for prolonged periods of time. If you feel lonely, you pick up the phone and call a friend, and then it goes away, or you get in the car and go see a family member, that’s OK. That’s loneliness acting like hunger or thirst, a signal our body sends us when we need something for survival. It’s when it persists that it becomes harmful.” The national strategy is part of the Biden administration’s mental health efforts, said White House press secretary Karine Jean-Pierre, according to CNN. The Surgeon General’s framework for social… read on > read on >
Melanoma: What It Is, Causes, Types, Symptoms & Treatments
Of all the skin cancers, melanoma is the one that scares doctors and patients the most. Luckily, there are now several options for treatment should you be diagnosed with this aggressive, sometimes deadly, cancer. Melanoma affects over 1 million Americans, and its rates have risen significantly in the past 30 years, according to the American Academy of Dermatology (AAD). Here, experts explore what melanoma is, along with its causes, risk factors and key symptoms. Plus, you’ll learn about melanoma’s stages, types and treatments. What is melanoma? The American Cancer Society (ACS) explains that cancer occurs when cells begin to grow out of control. Melanoma is a type of cancer that starts in the pigment-making cells, known as “melanocytes.” While not as common as other forms of skin cancer, it is more serious. “Melanoma is more aggressive and more likely to spread to the lymph nodes,” said Dr. Hugh Greenway, a dermatologic surgeon with Scripps MD Anderson Cancer Center and Scripps Clinic in California. “It’ll spread to the liver, to the brain and throughout the body if not checked.” According to the AAD, ultraviolet light from the sun or tanning beds is the cause of melanoma. Risk factors include: Blistering sunburns Tanning bed use Light skin, light-colored eyes, or red or blond hair Moles that are asymmetrical or large Time in the sun without protection Numerous… read on > read on >
Thousands of Tons of Toxic Chemicals Are Released Into American Homes Each Year
Many common household products emit airborne toxins that can harm your health in ways up to and including cancer, a new study reports. Dozens of different types of consumer products contain toxic volatile organic compounds (VOCs), chemicals that escape as gases and accumulate in indoor air, researchers from the Silent Spring Institute and the University of California, Berkeley (UC Berkeley), reported. More than 100 types of products contain VOCs that can cause cancer, birth defects or other reproductive harm, according to their report published May 2 in the journal Environmental Science & Technology. More than 5,000 tons of VOCs were released from consumer products in California in 2020, the researchers estimated. The investigators identified 30 categories of products that deserve special scrutiny because they frequently contain harmful chemicals and may pose the greatest health risk. Formaldehyde, a known carcinogen, was the most common harmful VOC. It was found in nail polish, shampoo, makeup and many other types of personal care products. Other products that emit VOCs included cleaners, art supplies, laundry detergents, mothballs and adhesives. “This study is the first to reveal the extent to which toxic VOCs are used in everyday products of all types that could lead to serious health problems,” lead author Kristin Knox, a scientist at Silent Spring Institute, said in an institute news release. “Making this information public could incentivize… read on > read on >
Young Men Are Using Banned ‘SARM’ Supplements to Bulk Up, With Harmful Results
The U.S. Food and Drug Administration is once again warning consumers to avoid muscle-building “supplements” that are anything but a safe alternative to steroids. In an advisory sent out last week, the agency said it continues to receive reports of serious side effects linked to selective androgen receptor modulators (SARMs). The compounds mimic some of the effects of testosterone, and have long been under study for treating muscle-wasting and bone loss caused by certain medical conditions. None have been approved by the FDA, however, and the agency stresses that SARMs are drugs, not dietary supplements. Still, online companies are marketing SARM-containing products, with the help of social media. “Online vendors and social media influencers are using social media to make SARMs seem safe and effective,” the FDA said in its warning. Based on the reports the agency is receiving, that is far from the case: SARM-containing products are linked to sometimes life-threatening effects such as heart attacks, strokes and liver failure. Other side effects include testicular shrinkage, sexual dysfunction, fertility problems and even psychosis. The FDA has been warning consumers about the risks for years, and taken action against some companies that illegally market the products. But, experts said, because people are getting SARMs online from overseas companies, the problem is hard to tackle from the supply side. And from the consumer side, it may… read on > read on >