All Sauce from Weekly Gravy:

A federal appeals court on Wednesday said the abortion pill mifepristone could remain available for now. But the court’s judges added some provisions to their ruling: A block on mailing the pill to patients as well as stays on other measures the federal government has taken recently to boost access to the medication. The three-member panel partially overruled Judge Matthew Kacsmaryk’s ruling in Texas last week, which said the U.S. Food and Drug Administration’s approval of mifepristone back in 2000 was invalid. Mifepristone is typically given as the first of two drugs used during a medication abortion. The U.S. Justice Department had filed its appeal of the Texas ruling on Monday. “If allowed to take effect, the court’s order would thwart FDA’s scientific judgment and severely harm women, particularly those for whom mifepristone is a medical or practical necessity,” the appeal stated. In its preliminary ruling filed on Wednesday, the federal appeals court suggested a statute of limitations bars any legal challenge to the FDA’s approval of mifepristone. The court also seemed to consider the government’s view that removing a long-approved drug from the market would have “significant public consequences.” But it left in place parts of Kacsmaryk’s ruling that rolled back a loosening of restrictions on mifepristone by the FDA in recent years. That includes a 2016 move to allow the drug to be…  read on >  read on >

(HealthDay News) – Juul Labs on Wednesday reached a $462 million settlement with several states over the aggressive marketing of its electronic cigarettes to minors. This latest settlement includes New York, California, Colorado, the District of Columbia, Illinois, Massachusetts and New Mexico. Juul settled with West Virginia earlier this week. The company has already agreed already to pay out more than $1 billion to 47 states and territories, Juul Labs said in a statement. “The terms of the agreement, like prior settlements, provide financial resources to further combat underage use and develop cessation programs and reflect our current business practices,” Juul spokesman Austin Finan told the New York Times. The latest settlement represents a near “total resolution of the company’s historical legal challenges and securing certainty for our future,” he added. Finan noted that federal data shows that underage use of Juul products has declined 95% since 2019. State attorneys general in New York and California alleged that their investigations found that Juul executives knew their marketing was attracting teens, the Times reported. “Too many young New Yorkers are struggling to quit vaping and there is no doubt that Juul played a central role in the nationwide vaping epidemic,” New York Attorney General Letitia James said in a statement on the settlement. While the company hasn’t admitted wrongdoing, its payments to plaintiffs in earlier lawsuits…  read on >  read on >

It sounds like the stuff of a vampire novel, but for people with a group of rare genetic disorders, exposure to sunlight can cause excruciating pain. Now, an experimental medication is showing promise for helping them better tolerate the light of day. In an early clinical trial, researchers tested the drug for patients with either of two related conditions: erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). Both belong to a group of eight rare genetic disorders called porphyrias. Studies estimate that EPP and XLP affect one in every 75,000 to 200,000 white people. Both conditions arise from certain genetic abnormalities that cause a chemical called protoporphyrin to build up in the blood and the lining of the blood vessels. The trouble comes when a person with EPP or XLP goes into the sun: That light activates protoporphyrin in the blood vessels, which triggers inflammation, cell damage and severe pain. Both disorders usually become apparent in childhood — which, clearly, takes a toll on kids’ quality of life, said Dr. Robert Desnick, one of the researchers on the new trial. “They call themselves shadow-jumpers, because they have to run from one shady spot to another to avoid the sun,” said Desnick, a professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, in New York City. Standard sunscreen offers no protection,…  read on >  read on >

As people with HIV live longer they’re at risk of premature heart disease. But a new study finds statin drugs can cut the risk of serious heart problems by more than one-third. The U.S. National Institutes of Health trial found the cholesterol-lowering drugs so effective, in fact, that the study was stopped early. Taking the daily statin pitavastatin calcium lowered the risk of major heart events by 35% in this patient group, according to an interim analysis of data from the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) study. “The REPRIEVE study reflects the evolution of HIV science, and progress from focusing mostly on approaches to treat and control the virus to finding ways to improve the overall health of people living with HIV,” said Dr. Hugh Auchincloss, acting director of the National Institute of Allergy and Infectious Diseases (NIAID). “These new data suggest that a common cholesterol-lowering medicine could substantially improve cardiovascular outcomes in people with HIV,” he said in a news release from the NIH and the NIAID. As people with HIV live longer thanks to decades of medical research and advances, premature heart disease and other chronic conditions have emerged as leading causes of illness and death. Statins are known to prevent heart disease in those at risk in the general population. But researchers weren’t certain before the trial if…  read on >  read on >

It’s not new for young people to develop an interest in their favorite pop singer or actor, but it can be problematic if that adoration turns toxic. It’s easier than ever to get lost in a celebrity’s carefully curated image via social media posts, according to Baylor College of Medicine in Houston, which offers some tips for when fandom goes too far. “Artists may do things that encourage people to get to know them better, so when they start giving people a peek into their lives and creating a persona that their fans can emotionally invest in, they get more people interacting with their work and also gain prestige and make more money,” explained Dr. Laurel Williams, an associate professor in the Menninger Department of Psychiatry and Behavioral Sciences at Baylor. Any fan can become unhealthily invested in celebrities or individuals, Williams said. Previously, fans had to spend money and time repeatedly to see a celebrity and then cultivate a connection that could turn obsessive — but in today’s internet age, celebrity channels are available online anytime. Superficial connections are now more easily and frequently made, Williams cautioned, and adolescents are more susceptible to having addictive emotions over this. “When someone starts ‘speaking their truth’ about a celebrity or topic in a way that dehumanizes others, either online or in person, that’s when you know…  read on >  read on >

Spring brings with it the joy of baseball, but too much of a good thing can lead to elbow injuries in young pitchers. An expert from UT Southwestern in Dallas offers some tips for youth baseball players, their parents and coaches about avoiding and being aware of injuries, including tears or ruptures of the ulnar collateral ligament (UCL). “Athletes 18 and younger should not pitch more than 100 innings in games during a calendar year,” said Dr. Nathan Boes, an assistant professor of orthopaedic surgery at University of Texas Southwestern Medical Center and director of sports medicine for Parkland Memorial Hospital in Dallas. “And they should take four months a year with no competitive pitching.” UCL injuries are the most common elbow injury among baseball players of all ages, from youth to major leagues. When the injury is severe, it can require reconstructive surgery, sometimes called Tommy John surgery, named after the pitcher who was the first to have the procedure in 1974 while with the Los Angeles Dodgers. The UCL runs along the inside of the elbow, with three bands that connect the upper arm bone to the largest of the forearm bones. What happens is that pitching’s repetitive motion causes microtraumas in the UCL. Symptoms include a popping sensation, swelling or irritation on the inside of the elbow, pain while throwing and numbness…  read on >  read on >

Financial stress and work lost to cancer treatment affects patients and their partners alike. Partners also experienced pain, fatigue and sleep issues owing to these fiscal worries, a new study found. “We know that financial toxicity or hardship is a significant effect of cancer and its treatment and is associated with poor health issues for patients and survivors,” said lead author Lauren Ghazal. She is a postdoctoral fellow at the Rogel Cancer Center and the University of Michigan School of Nursing. “Financial toxicity extends to caregivers or partners, too,” she said in a university news release. Her team wanted to understand how that toxicity affects the caregiver’s health, including anxiety, depression, fatigue and overall quality of life. “It is important to examine the full effect of financial toxicity on a household in order to develop multilevel interventions that center the patient,” she explained. For the study, the researchers surveyed patients who had been treated for stage 3 colon cancer one to five years earlier, as well as their spouses, domestic partners or significant others from the same household. In all, 307 patient-partner pairs responded. The survey asked about potential stressors including cutting spending, missing bill payments and debt from unpaid bills, bank loans or money borrowed. Patients and partners were also asked about physical function, anxiety, depression, fatigue, sleep disturbance, social roles, social activities and…  read on >  read on >

The “baby bust” that hit the United States during the first year of the COVID pandemic did not affect all states equally — with states that were more racially diverse or more “blue” seeing bigger drops in their birth rates. That’s among the findings of a new study that probed a now well-documented phenomenon: The pandemic triggered a drop-off in the U.S. birth rate, as it did in many other countries. That was the national picture at least. But the United States is geographically huge and diverse in many ways, said Linda Kahn, the senior researcher on the study and an assistant professor at NYU Grossman School of Medicine, in New York City. And as the new study demonstrates, the pandemic’s effects on birth rates differed from state to state. On the national level, Kahn’s team found what others have: Nine months into the pandemic, the U.S. birth rate was down compared to the year before — with 18 fewer births per month for every 100,000 women of childbearing age. But by the pandemic’s “second wave,” in 2021, the national birth rate had gotten back on track: That is, it returned to the declining trajectory it had been on in 2019. A deeper look, though, showed that states varied widely in how the early pandemic affected births. New York state, for example, saw a huge…  read on >  read on >

Over the past few years the escalating opioid crisis has touched off a complex debate about how best to reign in suicide risk among patients who are prescribed the addictive painkillers. The question: Could rapidly cutting back on legal opioid prescriptions help, or might patients’ desperation over lack of access inadvertently drive up suicide risk? Now new research suggests that opioid prescription rates and suicide risk appear to go hand-in-hand. As prescription rates fall, so does suicide risk. “People who are prescribed opioids, especially at higher doses, are at increased suicide risk,” said lead author Dr. Mark Olfson, a professor of psychiatry, medicine and law at Columbia University Irving Medical Center in New York City. Roughly 4 in 10 overdose suicide deaths across the U.S. involve opioids, Olfson pointed out. And suicide risk is twice as high among patients prescribed high-dose opioids as among those who receive low-dose options. But the role of legal prescribing patterns has been a matter of controversy and competing considerations, he said. “On one hand, increasing opioid prescriptions might increase suicide risks by expanding access to medications that are potentially fatal when mixed with other drugs — such as benzodiazepines — or when taken in excess.” Olfson said, adding that opioids also increase depression risk in some people. “On the other hand, lowering the dose of opioids too quickly or…  read on >  read on >

Adding menthol flavoring to electronic cigarettes may damage your lungs more than regular e-cigarettes do, a new study reveals. The common mint flavoring helps deliver lots more toxic microparticles, compared with e-cigarette pods that don’t contain menthol. It’s those microparticles that damage lung function, researchers say. “Beware of additives in the e-cigarettes,” said senior researcher Kambez Benam, an associate professor in the division of pulmonary, allergy and critical care medicine at the University of Pittsburgh’s School of Medicine. “If you vape, they can make you inhale more particles into your lungs. Don‘t assume that since menthol is a substance naturally found in mint plants and added to some food and beverages, it would be fine to inhale,” he said. “Menthol flavoring leads to a significantly higher number of particle counts that one would take into their lungs by vaping them,” he said. “E-cigarette aerosols are known to contain many harmful substances, such as nicotine and formaldehyde.” A number of studies have suggested that e-cigarette vapor can cause lung inflammation, oxidative stress, DNA damage and airway hyper-responsiveness that can trigger asthma, Benam said. Vaping these substances can cause lung damage that impairs lung function. Menthol, he added, is such a toxic substance. To look at the potential danger of menthol, Benam’s team developed a “vaping robot” that mimics the temperature, humidity, puff volume and duration of…  read on >  read on >