All Sauce from Weekly Gravy:

The “baby bust” that hit the United States during the first year of the COVID pandemic did not affect all states equally — with states that were more racially diverse or more “blue” seeing bigger drops in their birth rates. That’s among the findings of a new study that probed a now well-documented phenomenon: The pandemic triggered a drop-off in the U.S. birth rate, as it did in many other countries. That was the national picture at least. But the United States is geographically huge and diverse in many ways, said Linda Kahn, the senior researcher on the study and an assistant professor at NYU Grossman School of Medicine, in New York City. And as the new study demonstrates, the pandemic’s effects on birth rates differed from state to state. On the national level, Kahn’s team found what others have: Nine months into the pandemic, the U.S. birth rate was down compared to the year before — with 18 fewer births per month for every 100,000 women of childbearing age. But by the pandemic’s “second wave,” in 2021, the national birth rate had gotten back on track: That is, it returned to the declining trajectory it had been on in 2019. A deeper look, though, showed that states varied widely in how the early pandemic affected births. New York state, for example, saw a huge…  read on >  read on >

Over the past few years the escalating opioid crisis has touched off a complex debate about how best to reign in suicide risk among patients who are prescribed the addictive painkillers. The question: Could rapidly cutting back on legal opioid prescriptions help, or might patients’ desperation over lack of access inadvertently drive up suicide risk? Now new research suggests that opioid prescription rates and suicide risk appear to go hand-in-hand. As prescription rates fall, so does suicide risk. “People who are prescribed opioids, especially at higher doses, are at increased suicide risk,” said lead author Dr. Mark Olfson, a professor of psychiatry, medicine and law at Columbia University Irving Medical Center in New York City. Roughly 4 in 10 overdose suicide deaths across the U.S. involve opioids, Olfson pointed out. And suicide risk is twice as high among patients prescribed high-dose opioids as among those who receive low-dose options. But the role of legal prescribing patterns has been a matter of controversy and competing considerations, he said. “On one hand, increasing opioid prescriptions might increase suicide risks by expanding access to medications that are potentially fatal when mixed with other drugs — such as benzodiazepines — or when taken in excess.” Olfson said, adding that opioids also increase depression risk in some people. “On the other hand, lowering the dose of opioids too quickly or…  read on >  read on >

Adding menthol flavoring to electronic cigarettes may damage your lungs more than regular e-cigarettes do, a new study reveals. The common mint flavoring helps deliver lots more toxic microparticles, compared with e-cigarette pods that don’t contain menthol. It’s those microparticles that damage lung function, researchers say. “Beware of additives in the e-cigarettes,” said senior researcher Kambez Benam, an associate professor in the division of pulmonary, allergy and critical care medicine at the University of Pittsburgh’s School of Medicine. “If you vape, they can make you inhale more particles into your lungs. Don‘t assume that since menthol is a substance naturally found in mint plants and added to some food and beverages, it would be fine to inhale,” he said. “Menthol flavoring leads to a significantly higher number of particle counts that one would take into their lungs by vaping them,” he said. “E-cigarette aerosols are known to contain many harmful substances, such as nicotine and formaldehyde.” A number of studies have suggested that e-cigarette vapor can cause lung inflammation, oxidative stress, DNA damage and airway hyper-responsiveness that can trigger asthma, Benam said. Vaping these substances can cause lung damage that impairs lung function. Menthol, he added, is such a toxic substance. To look at the potential danger of menthol, Benam’s team developed a “vaping robot” that mimics the temperature, humidity, puff volume and duration of…  read on >  read on >

Jouncing along to school in a fume-spewing, rattletrap yellow bus is practically a rite of passage for most American students. But outdated buses actually wind up costing kids many days of education, thanks to the clouds of diesel exhaust left in their wake, a new study argues. School districts that upgrade to a “greener” bus fleet have higher attendance rates than those with older, dirtier-running buses, researchers report. Replacing all school buses built prior to 2000 could add more than 1.3 million additional student days of attendance each year in the United States, the study estimated. About 25 million children ride the bus to school every day, the researchers said. Older buses cough out higher levels of diesel exhaust, which can trigger asthma attacks in kids, said lead researcher Meredith Pedde, a research fellow in epidemiology with the University of Michigan. “Air pollution can even affect those without asthma,” Pedde added. “It has been linked to upper respiratory infections, pneumonia and other types of respiratory illness, so it might be impacting a larger student body than just asthmatic students.” To see whether cleaner buses cut down on student absences, Pedde and her colleagues examined data from the U.S. Environmental Protection Agency’s School Bus Rebate Program. The EPA program doled out more than $7 million annually to replace or retrofit old polluting buses between 2012 and…  read on >  read on >

(HealthDay News) – The U.S. Justice Department on Monday appealed a Texas court ruling that invalidates the U.S. Food and Drug Administration’s approval in 2020 of mifepristone, the first of two drugs taken during a medical abortion. The ruling by U.S. District Judge Matthew Kacsmaryk in Texas is “extraordinary and unprecedented,” the Justice Department said in its appeal. “If allowed to take effect, the court’s order would thwart FDA’s scientific judgment and severely harm women, particularly those for whom mifepristone is a medical or practical necessity.” Pharmaceutical executives have also weighed in on the ruling, signing a letter on Monday warning about the impact if the Texas order was to take effect. “If courts can overturn drug approvals without regard for science or evidence, or for the complexity required to fully vet the safety and efficacy of new drugs, any medicine is at risk for the same outcome as mifepristone,” stated the letter, according to the Associated Press. While Kacsmaryk’s ruling said the order would not take effect for seven days, within 20 minutes of the order a federal judge in Washington state issued a ruling directing the FDA to make no changes that would restrict access to the drug in 17 states where Democrats had sued, the AP reported. The Justice Department has asked for clarification on that ruling. The Texas lawsuit was filed…  read on >  read on >

Intermittent fasting is all the rage due to its laundry list of potential health benefits — from weight loss to longevity. Now, new research suggests that it may beat low-calorie diets when it comes to preventing type 2 diabetes in high-risk people. Folks who only ate between 8 a.m. and noon for three days a week and ate normally for the other four days showed greater improvements in blood sugar metabolism for at least six months when compared with people who followed a low-calorie diet. Interestingly, folks in both groups lost the same amount of weight during the study period. “Our study indicates that meal timing and fasting advice extends the health benefits of a restricted calorie diet, independently from weight loss, and this may be influential in clinical practice,” said study author Xiao Tong Teong, a postdoctoral researcher at the University of Adelaide in Australia. For the study, researchers compared a time-restricted intermittent fasting diet to a low-calorie diet in more than 200 people, to see which had a greater effect on the risk for developing type 2 diabetes. They looked at postprandial blood sugar, a measure of glucose in the bloodstream after eating. If these levels are too high, it suggests a greater risk of type 2 diabetes, the form of the disease most closely related to obesity. Previous studies suggested eating earlier…  read on >  read on >

ChatGPT, the AI chatbot everyone is talking about, can often give reliable answers to questions about breast cancer, a new study finds. But it’s not yet ready to replace your physician. The big caveat, researchers said, is that the information is not always trustworthy, or offers only a small part of the story. So at least for now, they said, take your medical questions to your human doctor. ChatGPT is a chatbot driven by artificial intelligence technology that allows it to have human-like conversations — instantly generating responses to just about any prompt a person can cook up. Those responses are based on the chatbot’s “pre-training” with a massive amount of data, including information gathered from the internet. The technology was launched last November, and within two months it had a record-setting 100 million monthly users, according to a report from the investment bank UBS. ChatGPT has also made headlines by reportedly acing the college SATs, and even passing the U.S. medical licensing exam. Despite that suggestion that the chatbot could be a doctor, it’s still far from clear whether it provides users with trustworthy medical information. The new study, published April 4 in the journal Radiology, tested the chatbot’s ability to answer some “fundamental” questions on breast cancer screening and prevention. Overall, it found, the technology provided appropriate answers 88% of the time. Whether…  read on >  read on >

A Texas federal judge has issued a preliminary ruling that invalidates the U.S. Food and Drug Administration approval in 2000 of mifepristone, the first of two drugs most commonly taken during a medical abortion. Judge Matthew Kacsmaryk added a seven-day stay to his order, issued Friday, to give the FDA time to mount an appeal. About an hour later, Washington state federal judge Thomas Rice issued a countering decision in a case filed there, ordering a halt to “any action to remove mifepristone from the market or otherwise cause the drug to become less available.” The two opposing rulings would suggest that any final decision on the availability of mifepristone, which is typically given alongside misoprostol to cause an abortion, may end up at the Supreme Court. The Washington state lawsuit originated with Democratic attorneys general who were challenging restrictions in place that made it difficult to obtain mifepristone. The Texas decision involves a lawsuit filed by a coalition made up of doctors and anti-abortion groups who sought an end to the use of mifepristone, claiming that the FDA’s decision 23 years ago to approve the drug was made hastily and without proper regard for its overall safety. In his decision, Kacsmaryk said that, ”The court does not second-guess [the] FDA’s decision-making lightly. But here, FDA acquiesced on its legitimate safety concerns — in violation…  read on >  read on >

Put out that cigarette for the health of your four-legged friend. When smokers search social media for anti-tobacco information, they tend to engage most with posts about the risk of secondhand smoke on their pets, a new study reveals. Posts with new information about harmful chemicals also receive high engagement, researchers found. “Our results show that people respond to messaging on how smoking negatively affects the lives of those they care about, including pets. Messages that are personally meaningful to smokers can help to generate positive behavioral changes among smokers,” said principal investigator Hong Xue, an associate professor of health administration at George Mason University in Fairfax, Va. “Anti-tobacco campaigns can use these findings to improve their campaigns, better engage the public, and more effectively promote reasons to stop smoking,” he said in a university news release. The researchers used machine learning and social media data to analyze factors that influence effective anti-smoking campaigns and user engagement. The study was led by Xue and GMU associate professor Gilbert Gimm. They described their work as the first large-scale social media data mining study that examined key anti-tobacco campaigns in the United States. Their research also found that large campaigns from government and nonprofit organizations had greater user engagement than smaller and local campaigns. Facebook users were much more likely to engage in messages with videos. About…  read on >  read on >

Dangerously low blood pressure is considered an “invisible” consequence of paralysis, adding to the woes of as many as 9 out of 10 people with spinal cord injuries. Now, a new implant has been developed that treats the problem by delivering electrical stimulation to a select group of spinal neurons. The device, called a neuroprosthetic baroflex, stimulates the lower part of the spine, which contains the most neurons involved in blood pressure control, researchers said. The findings were published April 6 as an essay in Science. Spinal cord injury often interferes with the brain’s ability to modulate blood pressure when a person changes posture, such as moving from a sitting to a standing position. This ability, called the baroreceptor reflex, involves a series of quick responses within the body to keep blood pressure in a normal range when someone abruptly changes position, the Cleveland Clinic says. The brain senses that artery walls are stretching due to a sudden increase in blood pressure. In response, the brain can order the body to compensate, though a series of reactions that take place within a couple of heartbeats. A person with a spinal cord injury can be rendered dizzy, nauseous or prone to fainting if their baroreceptor reflex fails and their blood pressure drops to very low levels as a result of trying to move. “Almost all of…  read on >  read on >