An experimental drug may one day be a cure for eczema, a new trial suggests. The drug, rocatinlimab, is a monoclonal antibody that researchers found prevented the recurrence of the symptoms of the skin condition for up to 20 weeks after treatment was stopped. “Patients ask us in the clinic all the time, ‘Can I stop the medication, or can I start doing it much less often?’ Right now we don’t have those medications available,” said lead researcher Dr. Emma Guttman, professor and system chair of dermatology and immunology at the Icahn School of Medicine at Mount Sinai in New York City. “Of course, it’s important in adults, but imagine, in the future, how important this is in children. This drug may cause disease modification because it works on memory T-cells,” she explained. The drug works by blocking OX40 — an immune molecule that activates inflammatory cells that play a role in the development of eczema, also called atopic dermatitis. The drug also prevents memory T-cells from storing the key to eczema. “Because it works on memory T-cell formation, the cells that remember that the patient has the disease, maybe these cells will not come back to cause the disease again,” Guttman said. Atopic dermatitis is a debilitating chronic inflammatory skin disease, which often develops at a very young age, causing the skin to become… read on > read on >
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Loss of Bees Could Harm Health of Millions of People
Bees, in their role as master pollinators, increase crop yields, leading to more production of healthy fruits, vegetables and nuts. But new research claims that the challenges these important insects face from changes in land use, harmful pesticides and climate change is affecting food production, leading to less healthy food in global diets and more diseases causing excess deaths. “A critical missing piece in the biodiversity discussion has been a lack of direct linkages to human health. This research establishes that loss of pollinators is already impacting health on a scale with other global health risk factors, such as prostate cancer or substance use disorders,” said senior study author Samuel Myers. He is a principal research scientist of planetary health in the department of environmental health at the Harvard T.H. Chan School of Public Health, in Boston. Inadequate pollination has led to a 3% to 5% loss of produce and nut production, according to the study. That is associated with an estimated 427,000 excess deaths annually from illnesses such as heart disease, stroke, diabetes and certain cancers, the researchers said. A 1% to 2% annual decline of insect populations has led some to warn of an “insect apocalypse” that will come in the decades ahead. Pollinators would be part of that, seriously affecting healthy food supply because they increase the yields of three-fourths of crop… read on > read on >
Insulin Pumps Ease Diabetes Care. So Why Are Black Patients Less Likely to Get One?
Insulin pumps can help folks with type 1 diabetes get better control of their disease and minimize how often they inject insulin, and use of the devices has taken off in the past 20 years. That’s the good news from a new study. The not-so-great news is that a large gap in who is using these insulin pumps remains. Specifically, white patients are twice as likely to receive an insulin pump as Black patients, and better-educated, wealthier people are also more likely to be using one. “The big message is that over a 20-year period, we saw a pretty large increase in insulin pump use across all patients, but no change in distribution by race or socioeconomic status,” said study author Dr. Estelle Everett, an assistant professor at the David Geffen School of Medicine at the University of California, Los Angeles. “Despite the overall increase, most populations are really not able to benefit from insulin pump use and these are the groups who have more challenges managing their diabetes and a higher risk of complications, so they may actually gain the most benefit from diabetes technology,” she said. Unfortunately, such race and socioeconomic disparities exist throughout medicine. “This study is another example of a larger issue in the medical field,” Everett said. People with type 1 diabetes produce little to no insulin, the hormone tasked… read on > read on >
Exercise, Mindfulness May Not Boost Seniors’ Thinking, Memory
Exercise and mindfulness are known for their health benefits, but a new study found that didn’t extend to boosting memory or thinking skills in healthy seniors. That doesn’t mean these activities wouldn’t be beneficial for memory if practiced for a longer period of time or in adults with impairments, the researchers noted, just that there were not apparent benefits during the study. “We know beyond any doubt that exercise is good for older adults, that it can lower risk for cardiac [heart] problems, strengthen bones, improve mood and have other beneficial effects — and there has been some thought that it also might improve cognitive [thinking] function,” said study first author Dr. Eric Lenze. He is head of the department of psychiatry at Washington University School of Medicine in St. Louis. “Likewise, mindfulness training is beneficial because it reduces stress, and stress can be bad for your brain. Therefore, we hypothesized that if older adults exercised regularly, practiced mindfulness or did both, there might be cognitive benefits — but that’s not what we found,” Lenze said in a university news release. The researchers studied this in 585 adults aged 65 to 84 for up to 18 months. None had been diagnosed with dementia, though all worried about minor memory issues. “Minor memory problems often are considered a normal part of aging, but it’s also normal… read on > read on >
What’s Driving the Ongoing Adderall Shortage — and What Parents Can Do
Shortages of the ADHD drug Adderall are expected to continue for months, forcing families to scramble for ways to deal with their children’s attention deficit hyperactivity disorder (ADHD). The shortage has caused headaches and hassles for parents like San Diego mom Jackie Meader, who has been “flustered, rushed and out of sorts” since her 16-year-old son’s prescription ran out about a month ago. “He’s telling me he’s having trouble at school, can’t focus. He’s struggling, and it’s not just a matter of not being able to focus on things. He’s having trouble staying awake,” Meader told KGTV News in San Diego. An abrupt halt to Adderall treatment can cause physical symptoms like lethargy and fatigue, but some kids might become jittery, said Dr. Anish Dube, chair of the American Psychiatric Association’s Council on Children, Adolescents and their Families. It also might cause the child to feel hungry and eat more, since stimulants tend to decrease appetite, Dube said. But mainly, kids who are off their Adderall are likely to have their ADHD symptoms return, Dube said. “Particularly if Adderall had been effective in helping with these symptoms, when you have it being stopped, then you might have a return of the original symptoms that the child had,” Dube said. The FDA first declared a shortage of the immediate-release formulation of Adderall on Oct. 12. The… read on > read on >
Most People With COPD Enjoy Good Mental Health: Study
Surprisingly, most people suffering from chronic obstructive pulmonary disease (COPD) are in excellent mental health, Canadian researchers report. Two-thirds of COPD patients don’t suffer from common mental health issues such as depression, anxiety or addiction to drugs, the new study found. The key to well-being seems to be having the support of loved ones and not being isolated or lonely, according to a new study. COPD is a progressive, debilitating chronic lung disease that includes emphysema and chronic bronchitis. The condition has previously been tied to mental health problems, researchers noted. “This is not an easy disorder,” said senior researcher Esme Fuller-Thomson, director of the Institute for Life Course and Aging at the University of Toronto. But to see that two-thirds of people who have COPD — which can make it hard to breathe and interfere with their ability to work and participate in family activities — are overcoming those difficulties to the point that they are mentally flourishing is heartening, she said. For the study, Fuller-Thomson and her colleague Sally Abudiab, a graduate of the University of Toronto’s Factor-Inwentash Faculty of Social Work, looked at the mental health of 703 COPD patients. They found that 67% of the participants were in excellent mental health. According to Fuller-Thomson, that meant being happy and satisfied with their life most of the time, having social and psychological… read on > read on >
Formula Feeding Raises Odds for Anemia in Very ‘Preemie’ Babies
Babies born prematurely who are fed formula may need iron supplementation like their breastfed counterparts, new research suggests. “Just because a baby is on iron-rich formula, we should not assume all of their iron needs are being met, since iron from the formula may not have the same absorption as iron from breast milk,” said researcher Grace Power. She is a third-year medical student at Dalhousie University in Nova Scotia, Canada. “These findings suggest we might need to rethink some of the guidelines for iron supplementation,” she said in a news release from the American Society of Hematology. Currently, the Canadian Pediatric Society recommends iron supplementation for breastfed preterm babies, but not for those fed formula because the formula contains more iron than breastmilk. The American Academy of Pediatrics does not offer recommendations on iron supplementation for preterm babies. For the new study, the researchers analyzed health records from 392 infants born before 31 weeks’ gestational age in Nova Scotia from 2005 to 2018. The data set is considered to be representative of the general Canadian population. About three-quarters of the infants in the study were exclusively fed iron-rich formula. The other one-quarter were partially or exclusively breastfed. The investigators gathered data on feeding practices, iron intake from formula and iron supplements, and iron levels in the blood taken at 4 and 6 months of… read on > read on >
After Angioplasty, Depression Can Keep Heart Patients From Taking Meds
Patients who undergo angioplasty and stenting to open clogged arteries in and around the heart should also be screened for depression, according to a new study. Researchers found that depressed patients were less likely than their mentally healthy peers to take their prescribed medications, including beta-blockers, antiplatelets and statins. These medications reduce the likelihood of another heart attack or cardiovascular event after angioplasty and stenting (also called percutaneous coronary intervention, or PCI). “It is well-appreciated that depression carries adverse cardiovascular risk. We wanted to understand better why that is the case,” said Dr. Jared Magnani, a cardiologist and associate professor of medicine at the University of Pittsburgh. “We found that 10% to 20% of individuals with depression were less likely to take their medicine after PCI, which is significant because this group is at a higher risk for serious complications or dying from a heart attack,” he said in a university news release. Using medical claims data that included prescriptions filled at pharmacies, the researchers examined the records of more than 124,000 patients who had the procedure and were also diagnosed with depression. Patients were followed for a year. Medication adherence may depend on social factors, such as having the money to cover medication costs, the study authors noted. Pharmacy access is another challenge. Prior research has found that a high percentage of people with… read on > read on >
Smoking, Vaping Both Bad for Your Teeth & Gums: Study
For those who care about their teeth, a new study sounds a pretty clear alarm: using tobacco in any form — including the increasingly popular practice of vaping — is a recipe for a dental nightmare. The warning comes from the U.S. National Institute of Dental and Craniofacial Research (NIDCR), after scientists analyzed several years of tracking data that looked at associations between smoking and poor dental health among thousands of American men and women. The bottom line: regular users of cigarettes, electronic cigarettes (vapes), cigars, pipes, hookahs and/or smokeless tobacco face a notably higher risk for various forms of dental trouble. Depending on the type of tobacco involved, that includes a significantly heightened likelihood for six different types of dental concerns, including gum disease; precancerous oral lesions; bone loss surrounding the teeth; loose teeth; and/or tooth loss due to tooth decay or gum disease. And vaping, which is sometimes viewed as a safer form of tobacco use, was linked to a 27% higher risk for bleeding following brushing or flossing. “We’ve always known that smoking increases your odds for gum disease,” said Dr. Purnima Kumar, a spokesperson for the American Dental Association. Though not a part of the study team, Kumar — who is also chair of the department of periodontics and oral medicine at the University of Michigan School of Dentistry, in Ann… read on > read on >
Herbals, Yoga, Ginkgo: What Alternative Treatments Help Fight Heart Failure?
It’s tempting to follow the latest trend when it comes to health care, but for patients who live with heart failure, some alternative treatments could have serious consequences. To address the issue, the American Heart Association (AHA) has published a new scientific statement covering a wide range of alternative therapies and their impact on heart failure. It also offers guidance for health care professionals and recommendations for patients. “Patients should talk to their health care team first,” said Dr. Sheryl Chow, who was part of the AHA’s writing group for the statement. The AHA paper offers guidance on supplements such as CoQ10, vitamin D, ginkgo, devil’s claw, fish oil, thiamine, hawthorn, vitamin E, blue cohosh, lily of the valley and aloe vera, while offering additional advice on alcohol, caffeine and grapefruit juice. “Because these agents are largely unregulated by the [U.S. Food and Drug Administration], manufacturers do not need to demonstrate efficacy or safety,” explained Chow, an associate professor of pharmacy practice and administration at Western University of Health Sciences in Pomona, Calif. “It is important that both health care professionals and consumers are educated about potential efficacy and risk of harm, so that shared and informed decision-making can occur.” The committee also reviewed yoga and tai chi, commonly suggested for relaxation. About 6 million Americans aged 20 and up have heart failure, where their… read on > read on >