All Sauce from Weekly Gravy:

Patients with severe COVID-19 may be at risk for a variety of brain complications — from stroke to psychosis, new research suggests. “There have been growing reports of an association between COVID-19 infection and possible neurological or psychiatric complications, but until now these have typically been limited to studies of 10 patients or fewer,” said lead study author Benedict Michael. He is a fellow in the Institute of Infection and Global Health at the University of Liverpool in the United Kingdom. The study, described as the first nationwide look at neurological complications of infection with the new coronavirus, looked at 125 COVID-19 patients treated in U.K. hospitals during April. Michael emphasized that it focused only on cases that were serious enough to require hospitalization. The most common brain complication was stroke, which occurred in 77 patients. Of those strokes, 57 were caused by a blood clot in the brain, nine by bleeding in the brain and one by inflammation in the blood vessels of the brain. Most of the patients who had a stroke were older than 60 years of age. Thirty-nine patients experienced confusion or behavior changes that suggested they had an altered mental state, the study found. Of those, nine had unspecified brain dysfunction (encephalopathy), seven had inflammation of the brain (encephalitis), and 23 were diagnosed with psychiatric conditions, the researchers said. Ninety-two…  read on >

Huge declines in patient visits during the coronavirus pandemic have slashed U.S. primary care doctors’ revenues, a new study finds. As a result of decreases in office visits and fees for services from March to May during the pandemic, a full-time primary care physician will lose an average of more than $65,000 in revenue in 2020. Overall, primary care practices nationwide stand to lose nearly $15 billion, according to the study led by a team from Harvard Medical School in Boston. “For many primary care practices, particularly those serving the most vulnerable populations, these losses could be catastrophic, with many practices being forced to close,” study author Dr. Sanjay Basu, a faculty affiliate at Harvard’s Center for Primary Care, said in a university news release. “This could weaken the U.S. health system dramatically at a time when we need it to be at its strongest.” Researchers warned that revenue losses would rise if there is a second wave of infection this year or reimbursement rates for telehealth visits return to pre-pandemic levels. Such losses could lead practices to close and worsen an existing shortage of primary care providers in the United States. “Our prior work shows that primary care saves lives, and loss of primary care practices will translate to lives lost across the United States,” said study co-author Dr. Russell Phillips, director of the…  read on >

More and more U.S. states are allowing marijuana to be taken as medicine, and a new study suggests that users do indeed feel better. In a survey of nearly 1,300 people with chronic health conditions, researchers found that those using “medicinal cannabis” reported less pain, better sleep and reduced anxiety. They also tended to use fewer prescription medications and were less likely to have been to the hospital recently. A majority of U.S. states have made marijuana legal for medical or recreational use, and studies have looked at whether those laws are linked to increased marijuana use, car accidents or emergency room visits. But little research has examined the impact of legalization on the people who use medicinal cannabis, said senior study author Ryan Vandrey, an associate professor of psychiatry and behavioral sciences at Johns Hopkins University School of Medicine in Baltimore. The finding that cannabis users felt better than nonusers is not necessarily surprising, according to Vandrey. But it’s important to demonstrate it in a study, he said. The results do not prove, however, that medicinal cannabis is effective. It’s also unclear whether certain products were linked to particular benefits. Medicinal cannabis included not only formulations of THC — the chemical behind marijuana’s “high” — but also cannabidiol, or CBD, which does not create a high. Fifty-eight percent of users were taking “CBD-dominant” oils,…  read on >

Happy couples apparently make good bedfellows. New research says that when happy couples sleep together, they tend to have more — and less disrupted — rapid eye movement (REM) sleep. The REM phase of sleep is when you dream, and it’s been linked to emotion regulation, memory consolidation and creative problem-solving, the researchers said. “There is — even in the medical community — the notion that if you sleep with a partner, you might subjectively think that you slept well or better, but objectively, your sleep is more disturbed,” said the study’s lead author, Dr. Henning Drews, a resident and post-doctoral scholar at the Center for Integrative Psychiatry in Kiel, Germany. But, he noted that the current study found that “if you want to share a bed with your partner, there is nothing to be said against it. It might even be very good for you.” For the study, 12 young, healthy couples between 18 and 29 years old volunteered to spend four nights in a sleep lab. They had been sleeping together most nights for at least three months. For two nights, the couples slept in different rooms. On another two nights, they slept together. Half of the group started apart, while the other half started the study together. Using polysomnography, the researchers simultaneously measured what went on during sleep in each partner. Polysomnography…  read on >

As the United States reported yet another record-breaking number of new coronavirus cases on Thursday, public health officials warned that younger Americans now account for an ever-growing percentage of infections. In Arizona, where drive-up testing sites were being overwhelmed, nearly half of all cases are being seen in those aged 20 to 44, The New York Times reported. In Florida, which has been routinely breaking records for new cases in the past week, the median age of residents testing positive for the virus has dropped to 35, down from 65 in March. In Texas, where cases are soaring and hospitals are nearing capacity, young people now make up the majority of new cases in several urban areas, the newspaper said. “What is clear is that the proportion of people who are younger appears to have dramatically changed,” said Joseph McCormick, a professor of epidemiology at UTHealth School of Public Health in Brownsville, Texas, told the Times. “It’s really quite disturbing.” The troubling news came as the United States recorded nearly 40,000 new coronavirus cases on Thursday, the Washington Post reported. COVID-19 infections in the United States had been slowing since the prior record of 36,739 cases back on April 24, but case counts have roared back in recent weeks, the Times reported. Coronavirus cases are surging the most in the South and West. On Thursday,…  read on >

Kids as young as age 8 can show signs of being at increased risk for diabetes in adulthood, a British study finds. Researchers analyzed blood samples collected from more than 4,000 participants at ages 8, 16, 18 and 25, looking for patterns specific to early stages of type 2 diabetes development. “We knew that diabetes doesn’t develop overnight. What we didn’t know is how early in life the first signs of disease activity become visible and what these early signs look like,” said study co-author Joshua Bell, an epidemiologist at the University of Bristol. While diabetes is most common in older age, signs that one is prone to it can be seen about 50 years before it’s typically diagnosed, the researchers said. “Knowing what these early signs look like widens our window of opportunity to intervene much earlier and stop diabetes before it becomes harmful,” Bell said in a university news release. He and his colleagues found that in susceptible children, certain types of “good” HDL cholesterol were lower at age 8 before other types of cholesterol, including “bad” LDL, increased. By ages 16 and 18, inflammation and amino acids were also elevated, the study showed. These differences widened over time. “We’re talking about the effects of susceptibility rather than of clinical disease itself,” Bell said. “This does not mean that young people ‘already have…  read on >

With opioid addiction soaring in the United States, it should come as good news that an opioid painkiller may not be needed after a sports-injury repair. A mix of non-addictive medicines may be safer and equally successful in managing pain after shoulder or knee surgery, a study from Henry Ford Hospital in Detroit indicates. Concerned about the opioid abuse epidemic, doctors there tested a different regimen for pain relief. They treated post-surgical pain with a combination of non-opioid medications, including anti-inflammatories, muscle relaxants and nerve pain relievers. Nearly half of the study participants required no opioids for pain relief. “It’s a complete change,” said lead author and orthopedic surgeon Dr. Vasilios Moutzouros. He added that he was taught in medical school “the only mode of pain relief is opioid medication.” Opioid overdose is the leading cause of accidental death in the United States, and orthopedic surgeons write a substantial number of opioid prescriptions, the authors said in background notes. The study builds on earlier research showing use of opioids after orthopedic surgery can be reduced, but goes further in suggesting that the drugs may be eliminated. Changing how pain is treated could keep people from ever being introduced to opioids, Moutzouros said. The study focused on 141 patients who underwent anterior cruciate ligament (ACL) reconstruction, or repairs for a torn knee meniscus or rotator cuff…  read on >

Both cyberbullies and their victims can suffer from symptoms of post-traumatic stress disorder (PTSD), a new British study finds. Cyberbullying is bullying online rather than in person. It’s so pervasive that pediatricians should routinely ask their patients about it as part of psychological assessment, the researchers said. “Parents, teachers and health professionals need to be aware of possible PTSD symptoms in young people involved in cyberbullying,” said study author Ana Pascual-Sánchez and colleagues. She’s in the psychiatry division at Imperial College London. Cyberbullying among teenagers is estimated to range from 10% to 40%, said the researchers. Because it can be done anonymously day or night, it poses special risks, they noted. For the study, Pascual-Sánchez and her team collected data on more than 2,200 11- to 19-year-olds from four London schools who were surveyed about their experiences. The survey found that 46% had a history of any kind of bullying: 17% were victims; 12% were perpetrators; and 4% were both. Traditional bullying was more common than cyberbullying, the researchers found. Still, about 13% of the teens had been cyberbullied; 8.5% had bullied others online; and 4% had been both victims and perpetrators. About 16% of the kids had been bullied in person; 12% had bullied others in person; and 7% had been both victims and perpetrators, the researchers found. There was some overlap between types…  read on >

Restarting professional sports with fans in attendance may not be a good idea as it may increase COVID-19 deaths, a new flu study suggests. Cities with pro teams appear to have more flu deaths than cities without them, which may be important as the NBA, NFL and other leagues consider playing games while the coronavirus pandemic continues, researchers say. Several professional sports leagues in the United States have said they plan to resume play without fans in the stands while many soccer leagues around the world are doing the same, but France, Japan and Spain have announced plans to allow some sports fans back into stadiums before summer’s end. In the flu study, data from the U.S. Centers for Disease Control and Prevention from 1962 to 2016 indicate that flu deaths increased 5% to 24% during the NFL, NBA, NHL and MLB seasons. The biggest increase was for NHL games. Because COVID-19 is more contagious than the flu, researcher Brad Humphreys said, “Don’t let the fans back into the games.” Humphreys is a professor of economics at West Virginia University. “Opening pro sports games to fans is probably a terrible idea, in terms of public health,” he said in a university news release. “You’re right on top of people and everybody’s yelling, screaming, high-fiving and hugging. And you’ve got people eating and drinking. You could…  read on >

Blood plasma transfusions from people who have developed antibodies to the new coronavirus appear to be safe for many COVID-19 patients, a large study suggests. The experimental treatment — called convalescent plasma therapy — is popular because no drug has been approved specifically to treat coronavirus infection. A week after 20,000 COVID-19 patients deemed at risk for progressing to a severe or life-threatening condition received plasma therapy, their risk of death dropped to 9%, compared to 12% in a previous study, Mayo Clinic researchers reported. Fewer than 1% had serious side effects, the researchers added. The study included men and women, and significant numbers of patients who were Black, Hispanic or Asian. “We’re optimistic, but must remain objective as we assess increasing amounts of data,” principal investigator Dr. Michael Joyner, a vice chairman for research at the Mayo Clinic in Rochester, Minn., said in a clinic news release. The researchers can’t say for sure that the transfusions from recovered patients save lives. Joyner’s team pointed out that the results might be due to patients being less ill, or to better medical care. But because the treatment is being widely used with COVID-19 patients, study continues. Right now, convalescent plasma therapy is the only antibody treatment for COVID-19. Plasma is the liquid part of the blood. It contains both red and white blood cells, as well…  read on >