All Sauce from Weekly Gravy:

Coronavirus outbreaks in the Midwest and Western United States have driven the national case count to its highest level since August, fueling fears of what the coming winter will mean for the country. COVID-19 cases are starting to climb in 36 states, including parts of the Northeast, which is starting to backslide after months of progress, The New York Times reported. More than 820 new deaths and more than 54,500 new cases were announced across the country on Tuesday, the newspaper said. Idaho and Wisconsin set single-day records for new cases. About 50,000 new cases are being reported each day in the United States for the week ending Monday, the Times reported. That is still less than in late July, when the country was seeing more than 66,000 cases each day. But the trajectory is worsening, and experts fear what could happen as cold weather drives people indoors, where the virus can spread more easily, the newspaper said. The latest spike in cases shows up just before the increased mingling of people that comes with Halloween, Thanksgiving and Christmas. Sixteen states each added more new cases in the seven-day period ending Monday than they had in any other weeklong stretch of the pandemic. North Dakota and South Dakota are reporting more new cases per person than any state has previously, the Times reported. “A lot…  read on >

A second coronavirus vaccine trial was paused on Monday after an unexplained illness surfaced in one of the trial’s volunteers. Johnson & Johnson, which only began a phase 3 trial of its vaccine last month, did not offer any more details on the illness and did not say whether the sick participant had received the vaccine or a placebo. The trial pause was first reported by the health news website STAT. While Johnson & Johnson was behind several of its competitors in the vaccine race, its candidate has an advantage in that it doesn’t need to be frozen and it could be given in one dose instead of two, The New York Times reported. The J&J vaccine is also the focus of the largest COVID-19 vaccine trial, with a goal of enrolling 60,000 volunteers. “Adverse events — illnesses, accidents, etc. — even those that are serious, are an expected part of any clinical study, especially large studies,” the company said in a statement. “We’re also learning more about this participant’s illness, and it’s important to have all the facts before we share additional information.” “It’s actually a good thing that these companies are pausing these trials when these things come up,” Dr. Phyllis Tien, an infectious disease physician at the University of California, San Francisco, a vaccine trial site for both Johnson & Johnson and…  read on >

Hours after President Donald Trump held a rally on the White House lawn for hundreds of supporters, his doctor said he is “no longer considered a transmission risk to others.” In a memo released Saturday night, White House physician Dr. Sean Conley said he was sharing information about the status of Trump’s coronavirus infection with permission from Trump, The New York Times reported. But the amount of information he provided was limited. Trump was first diagnosed with COVID-19 on Oct. 2. Health experts have repeatedly questioned the severity of Trump’s illness, and his health could still deteriorate in the next few days, they added. “I don’t think he’s out of the woods for certain,” Dr. Krutika Kuppalli, an infectious disease physician based in South Carolina, told the Times. Trump’s recent course of steroids, which suppress certain parts of the immune system, could also make him vulnerable to other infections, Kuppalli added. “I would still be careful with someone like him.” The start date of Trump’s symptoms has also remained unclear, the Times reported. According to the U.S. Centers for Disease Control and Prevention, most people stop being infectious 10 days after becoming sick. By Conley’s assessment, Trump would have needed to show signs of his illness on Wednesday, Sept. 30, for Saturday to qualify as 10 days from the onset of symptoms. “This evening I…  read on >

Young women with cancer are at a high risk for employment and financial consequences, a new study finds. “Our study addresses the burden of employment disruption and financial hardship among young women with cancer — a group who may be at particular risk for poor financial outcomes after cancer given their age and gender,” said researcher Clare Meernik, a fellow at the University of North Carolina at Chapel Hill’s Lineberger Comprehensive Cancer Center. She and her colleagues surveyed more than 1,300 women in North Carolina and California a median of seven years after diagnosis. Their cancer was diagnosed when they were 15 to 39 years of age and working. Following their diagnosis, 32% of the women had to stop working or cut back on their hours. Twenty-seven percent said they had to borrow money, go into debt or file for bankruptcy because of cancer treatment. Women with disrupted employment were more likely — by 17 percentage points — to have these problems than women who were able to keep working. Half of the women said they were stressed about their big medical bills, and women with disrupted employment were more likely to suffer psychological distress by 8 percentage points than women who were able to keep working. The findings were published online Oct. 12 in the journal Cancer. “Our findings highlight the need for effective…  read on >

Hours after President Donald Trump held a rally on the White House lawn for hundreds of supporters, his doctor said he is “no longer considered a transmission risk to others.” In a memo released Saturday night, White House physician Dr. Sean Conley said he was sharing information about the status of Trump’s coronavirus infection with permission from Trump, The New York Times reported. But the amount of information he provided was limited. Trump was first diagnosed with COVID-19 on Oct. 2. Health experts have repeatedly questioned the severity of Trump’s illness, and his health could still deteriorate in the next few days, they added. “I don’t think he’s out of the woods for certain,” Dr. Krutika Kuppalli, an infectious disease physician based in South Carolina, told the Times. Trump’s recent course of steroids, which suppress certain parts of the immune system, could also make him vulnerable to other infections, Kuppalli added. “I would still be careful with someone like him.” The start date of Trump’s symptoms has also remained unclear, the Times reported. According to the U.S. Centers for Disease Control and Prevention, most people stop being infectious 10 days after becoming sick. By Conley’s assessment, Trump would have needed to show signs of his illness on Wednesday, Sept. 30, for Saturday to qualify as 10 days from the onset of symptoms. “This evening I…  read on >

Even as the nation’s top infectious diseases expert said Friday that the White House experienced a “superspreader” event in the Rose Garden last month, President Donald Trump announced he will hold his first public event at the White House since testing positive for the coronavirus a week ago. The Saturday event, which will have Trump speaking from a balcony to a crowd of supporters on the South Lawn, has already caused concern among some officials in the White House, which has been rocked by an outbreak following Trump’s diagnosis, the Washington Post reported. Trump’s medical team has not yet released the results of Trump’s latest COVID-19 test, so it was unclear whether Trump is still contagious, the Post reported. But Trump has ignored his advisers’ calls for caution, the newspaper reported, instead playing down the virus and using his own battle with it to argue that the nation has already overcome the pandemic. “I haven’t even found out numbers or anything yet, but I’ve been retested,” he said. “And I know I’m at either the bottom of the scale or free.” He added that he has been tested for the virus “every couple of days or so.” The lack of a negative test did not stop Trump from claiming to be cured and working from the Oval Office on Friday afternoon. Trump has been eager…  read on >

The new coronavirus is striking the Upper Midwest with a vengeance, as Wisconsin and the Dakotas became COVID-19 hotspots and health officials scrambled for hospital beds on Thursday. After months where residents of those states downplayed the virus and rejected mask requirements, all three now lead all other states in new cases per capita, the Associated Press reported. “It’s an emotional roller coaster,” said Melissa Resch, a nurse at Wisconsin’s Aspirus Wausau Hospital, which is working to add beds and reassign staff to keep up with a rising caseload of seriously ill COVID-19 patients. “Just yesterday I had a patient say, ‘It’s OK, you guys took good care of me, but it’s OK to let me go,’” Resch told the AP. “I’ve cried with the respiratory unit, I’ve cried with managers. I cry at home. I’ve seen nurses crying openly in the hallway.” What is unfolding in the Upper Midwest mirrors what has happened in other parts of the country since the pandemic began. In the spring, New York City hastily built field hospitals as emergency rooms were flooded with COVID-19 patients. Then, the coronavirus spread to states like Arizona, Texas, Florida and California over the summer. It then moved into the Midwest. “What worries me is we haven’t learned our lessons,” Ali Mokdad, a professor of health metrics sciences at the University of Washington…  read on >

The so-called love hormone, oxytocin, may be worth investigating as a treatment for COVID-19, a new study suggests. One of the most serious complications of infection with the new coronavirus is a “cytokine storm,” in which the body attacks its own tissues. There are currently no U.S. Food and Drug Administration-approved treatments for COVID-19, which means that “repurposing existing drugs that can act on the adaptive immune response and prevent the cytokine storm in early phases of the disease is a priority,” according to the researchers. Previous research suggests that oxytocin — a hormone that’s produced in the brain and is involved in reproduction and childbirth — reduces inflammation. In this new study, researcher Ali Imami, a graduate research assistant at the University of Toledo in Ohio, and colleagues used a U.S. National Institutes of Health database to analyze characteristics of genes treated with drugs closely related to oxytocin. The investigators found that one drug in particular, carbetocin, has similar characteristics (called a signature) to genes with reduced expression of the inflammatory markers that trigger cytokine storm in COVID-19 patients. Carbetocin’s signature suggests that the drug may trigger activation of immune cells called T-cells that play an important role in immune response. In addition, carbetocin’s signature is also similar to that of lopinavir, an antiretroviral medication under study as a treatment for COVID-19. All of…  read on >

Learning to play a musical instrument helps fine-tune kids’ brains, researchers say. In a new study, 40 children (aged 10 to 13) performed memory and attention tasks while their brain activity was monitored with functional MRI. This type of imaging scan detects small changes in blood flow within the brain. Twenty of the children played an instrument, had completed at least two years of lessons, practiced at least two hours a week and regularly played in an orchestra or ensemble. The other 20 children had no musical training other than in the school curriculum. The two groups had no differences in reaction time. But the musically trained children did better on the memory task, according to the report published online Oct. 8 in the journal Frontiers in Neuroscience. And along with better memory recall, the musically trained kids had more activation in brain regions associated with attention control and auditory encoding — functions associated with improved reading, higher resilience, greater creativity and a better quality of life. “Our most important finding is that two different mechanisms seem to underlie the better performance of musically trained children in the attention and … memory task,” said team leader Leonie Kausel, a violinist and neuroscientist at the Pontifical Catholic University of Chile, in Santiago. Music training may increase the functional activity of certain brain networks, Kausel explained in…  read on >

The type of heating coil used in an e-cigarette and the amount of voltage sent through it could be contributing to vaping-related lung injuries, a new animal study contends. Laboratory rats suffered lung injuries when exposed to vapor from devices using high-powered heating coils made of nickel-chromium alloy, something that did not occur in earlier experiments using stainless steel heating coils, researchers report. “When we looked at their lungs, we saw they had very severe damage to the lung structure,” said lead researcher Michael Kleinman, a professor of occupational and environmental medicine at the University of California, Irvine. “We found we got the worst effects in coils that contained nickel and chromium, which is a typical kind of coil.” E-cigarettes turn liquid into vapor using a heating coil similar to those found in toasters, Kleinman said. The coil is surrounded by the liquid, and when voltage is sent through the coil, it rapidly heats up. Kleinman and his colleagues were doing vaping research on lab rats using devices equipped with stainless steel coils when they made their discovery. The manufacturer stopped making the specific device they were using, so they had to switch to a compatible model that used nickel-chromium coils, Kleinman recalled. “When we got the new coils and we ran them at the high power settings, we immediately noticed after the first set…  read on >