Obesity is a well-known risk factor for severe COVID-19, and researchers think they’ve uncovered a possible reason why. Obese folks appear to have a blunted inflammatory response to COVID, leaving their immune systems less capable of fighting it, according to a recent study. The findings were a surprise to researchers, given that severe COVID often has been tied to an overactive immune response that produces damaging levels of inflammation in humans. People who are obese already have higher levels of inflammatory biochemicals in their blood, so it was suspected that COVID’s damaging inflammation would be even worse, noted researcher Menna Clatworthy, a clinician scientist at the University of Cambridge in the United Kingdom. “During the pandemic, the majority of younger patients I saw on the COVID wards were obese,” Clatworthy said in a university news release. “Given what we know about obesity, if you’d asked me why this was the case, I would have said that it was most likely due to excessive inflammation. What we found was the absolute opposite.” For this study, Clatworthy and her colleagues analyzed blood and lung samples taken from 13 obese patients with severe COVID who required mechanical ventilation and intensive care. They compared those samples against 20 COVID patients who weren’t obese and didn’t require ventilation. The researchers found the obese patients had underactive immune and inflammatory responses… read on > read on >







