
Severely obese people may need more frequent COVID-19 booster shots to keep their immunity going, new research suggests. Protection from the shots declines more rapidly in those who are severely obese compared to those at a normal weight, according to scientists at the Universities of Cambridge and Edinburgh in the United Kingdom. “Because of the high prevalence of obesity across the globe, this poses a major challenge for health services,” study co-author Sadaf Farooqi said in a Cambridge news release. She is from the Wellcome-MRC Institute of Metabolic Science at Cambridge. Past research has shown that COVID vaccination has been highly effective at reducing symptoms, hospitalization and death, including for people with obesity. Yet antibody levels may be lower in vaccinated obese people, potentially putting them at higher risk of severe disease and death, the researchers noted. To study this, a team from the University of Edinburgh, led by Aziz Sheikh, assessed data tracking the health of 3.5 million Scottish people as part of the EAVE II study. Specifically, they looked at hospitalization and death from COVID-19 in adults who received two doses of either the Pfizer-BioNTech mRNA vaccine or the AstraZeneca vaccine. (The AstraZeneca vaccine is not offered in the United States.) Those with a body mass index (BMI) greater than 40 — considered extreme obesity — had a 76% higher risk of severe… read on > read on >