Health/Fitness « Weekly Gravy

Quitting smoking will have benefits, even for those who are later diagnosed with lung cancer, new research indicates. While often studies compare outcomes for smokers vs. never smokers, investigators found that quitting smoking earlier also was beneficial. Among people diagnosed with the most common type of lung cancer, called non-small cell lung cancer, current smokers had 68% higher numbers of deaths compared to never smokers, while former smokers had only 26% higher numbers of deaths. And the longer a patient had quit smoking before being diagnosed with lung cancer, the better the odds of survival. “Our participants’ smoking histories varied, with some having stopped smoking a few years before their diagnosis and others having stopped several decades before,” said senior study author David Christiani, a professor of environmental genetics at Harvard T.H. Chan School of Public Health in Boston. “This wide range gave us confidence in our results — that the benefit of pre-diagnosis smoking cessation persists even after lung cancer is diagnosed,” he said in a university news release. The researchers studied nearly 5,600 patients with this common lung cancer who were enrolled in the Boston Lung Cancer Survival Cohort at Massachusetts General Hospital between 1992 and 2022. Among them, 795 had never smoked, 3,308 were former smokers and 1,491 were current smokers. Each participant answered questions about their smoking habits and other health… read on > read on >

Researchers think they’ve figured out why the COVID vaccine causes heart inflammation in an extremely small number of teenage boys — and what might be done to avoid it. The second dose of COVID vaccine appears to promote a severe inflammatory response in these teens, setting off a cascade of events that causes myocarditis (inflammation of the heart muscle), the researchers reported. Such a reaction probably can be avoided by allowing more time between the first and second doses, noted senior researcher Carrie Lucas, an associate professor of immunobiology at the Yale School of Medicine, in New Haven, Conn. “Our results fit with what others have found in clinical data thinking about the timing of the vaccine,” Lucas said. “When you space out the second dose of the vaccine, you will reduce that amount of cytokine and bystander immune activation, and potentially reduce the risk of myocarditis.” The study also rules out two other possible reasons why the second shot might cause myocarditis. Neither vaccine-induced antibodies nor an allergic reaction to the vaccine seems to be causing the heart inflammation, based on the evidence found in the blood samples studied, said co-researcher Akiko Iwasaki, a professor of immunobiology at the Yale School of Medicine. “This study really sheds light on which of these three hypotheses is likely going on, which is the inflammation-induced myocarditis,” Iwasaki… read on > read on >

In trying to untangle the mysteries of long COVID, researchers have found anxiety and depression may play a role for some of those with the lingering condition. In the study from researchers at University of California, Los Angeles (UCLA), patients who perceived that they had thinking difficulties during COVID infection were also more likely to have lingering physical symptoms than those who did not report thinking issues. About one-third of people with long COVID symptoms perceived they had thinking deficits, which have been found to be related to anxiety and depression. These findings suggest that psychological issues such as anxiety or depressive disorders play a part in some people experiencing long COVID. “This perception of cognitive [thinking] deficits suggests that affective issues — in this case anxiety and depression — appear to carry over into the long COVID period,” said senior study author Dr. Neil Wenger. He is a professor of medicine in the division of general internal medicine and health services research at the David Geffen School of Medicine at UCLA. “This is not to say that long COVID is all in one’s head, but that it is likely not a single condition and that for some proportion of patients there is likely a component of anxiety or depression that is exacerbated by the disease,” Wenger explained in a university news release. To study… read on > read on >

Chronic tendon issues are a frequent source of pain and can limit activity. They become more common with age, weight and certain activities, and early and appropriate diagnosis by a doctor is critical to get the best outcomes. The Achilles tendon is the biggest tendon in the human body. It connects the calf to the foot, and it is responsible for push-off power. The tendon is critical for stability during standing, walking, running and other activities. During muscle contraction, the tendon functions as a rope. It has elasticity to generate the tension required to handle the force of six times a person’s body weight. What is Achilles tendinitis? Over time, the tendon can become strained, injured or inflamed. On a day-to-day basis, people put stress on their Achilles tendon. A healthy tendon will handle this stress, repair any “microtears,” and a patient will have no symptoms. But over time, for various reasons, the Achilles tendon will develop inflammation and microtearing that will outpace the body’s ability to repair and heal the damage, and the patient will develop symptoms including pain, discomfort, soreness and swelling. This is Achilles tendinitis, and I often treat such cases here at Yale Medicine Orthopaedics & Rehabilitation. In reality, Achilles tendinitis is not just inflammation of the tendon, as the name implies. Achilles tendinitis is the accumulation of degenerative changes in… read on > read on >

Hundreds of thousands of people are jumping on the Ozempic bandwagon and taking prescription medications to slim down, while others swear by intermittent fasting and other diet fads, but new research shows that they’re all likely barking up the wrong trees. There isn’t any shortcut or magic bullet to losing weight, keeping it off, and improving your health, a new study of more than 20,000 people affirms. “Most adults slowly gain weight over decades of their life but turn to drastic, often dangerous, means to decrease body weight,” said study author Colleen Spees, an associate professor of medical dietetics at Ohio State University in Columbus. “Indeed, non-evidence-based diet practices are on the rise in large part due to social media influencers and popular actors.” Take the craze surrounding the injectable type 2 diabetes drug Ozempic, she said. “Although it is not U.S. Food and Drug Administration-approved for weight loss, individuals without diabetes are now taking Ozempic in hopes of rapid weight loss,” Spees said. Does it work? Yes, at least in the short term, she said. “Once individuals discontinue the use of this medication, their appetite returns along with the weight they lost while using it,” Spees added. For the study, researchers compared behaviors of more than 20,300 U.S. adults who were part of a national health and nutrition survey from 2007 to 2016. They… read on > read on >

Quitting smoking may leave you with more money for food. Having a tobacco smoker quit is not just a boon to lung health. In poorer families, it can also help prevent hunger, according to new research from the University of Minnesota School of Public Health. “We aimed to explore if tobacco cessation could improve food security,” said lead author Kaitlyn Berry, a PhD candidate. “Tobacco is expensive and addictive; in the U.S., on average, a pack of cigarettes currently costs about $8 — $240 per month for a pack-a-day smoker. “This means that when someone quits smoking, they can save a lot of money that could instead be used for other expenses,” Berry added in a school news release. Tobacco use and hunger are major threats to U.S. public health, according to the study. They inequitably affect low-income households and people of color. About 10% of all U.S. households don’t have enough food. Roughly one-third of households below the poverty line had hunger issues in 2021, the researchers reported. At the same time, people who are socially disadvantaged are more likely to smoke cigarettes, partly because of aggressive marketing by the tobacco industry to low-income groups. Uneven access to smoking-cessation programs is another contributor. The research team noted that 20% of adults with a household income under $35,000 smoke cigarettes. Yet only 6% of adults… read on > read on >

“Mindfulness” practices may help parents of young children with autism manage their daily stressors, and it could benefit their kids in the process, a preliminary study suggests. Parenting is stressful, and studies show that parents of kids with autism often have particularly high stress levels. Autism is a developmental brain disorder that, to varying degrees, impairs communication and social skills. Some kids have milder difficulties, but others are profoundly affected — speaking little, if at all, and getting wrapped up in repetitive, obsessive behaviors. Some children have intellectual disabilities, while others have average or above-average IQs. There are various therapies and services to help improve daily functioning and quality of life for kids with autism. But they typically do not address parents’ stress and coping skills, said Rachel Fenning, the lead researcher on the new study. Traditionally, she noted, there’s been something of an assumption that services that benefit children with autism will also help ease parents’ stress. But that is not necessarily true, since parents can be dealing with all kinds of challenges, said Fenning, who directs the Claremont Autism Center at Claremont McKenna College, in Claremont, Calif. The stressors can range from problems accessing autism services or learning how to implement a child’s therapy strategies at home, to the bigger-picture issues of balancing work and home life, paying the bills and more. So… read on > read on >

Of all the skin cancers, melanoma is the one that scares doctors and patients the most. Luckily, there are now several options for treatment should you be diagnosed with this aggressive, sometimes deadly, cancer. Melanoma affects over 1 million Americans, and its rates have risen significantly in the past 30 years, according to the American Academy of Dermatology (AAD). Here, experts explore what melanoma is, along with its causes, risk factors and key symptoms. Plus, you’ll learn about melanoma’s stages, types and treatments. What is melanoma? The American Cancer Society (ACS) explains that cancer occurs when cells begin to grow out of control. Melanoma is a type of cancer that starts in the pigment-making cells, known as “melanocytes.” While not as common as other forms of skin cancer, it is more serious. “Melanoma is more aggressive and more likely to spread to the lymph nodes,” said Dr. Hugh Greenway, a dermatologic surgeon with Scripps MD Anderson Cancer Center and Scripps Clinic in California. “It’ll spread to the liver, to the brain and throughout the body if not checked.” According to the AAD, ultraviolet light from the sun or tanning beds is the cause of melanoma. Risk factors include: Blistering sunburns Tanning bed use Light skin, light-colored eyes, or red or blond hair Moles that are asymmetrical or large Time in the sun without protection Numerous… read on > read on >

The U.S. Food and Drug Administration is once again warning consumers to avoid muscle-building “supplements” that are anything but a safe alternative to steroids. In an advisory sent out last week, the agency said it continues to receive reports of serious side effects linked to selective androgen receptor modulators (SARMs). The compounds mimic some of the effects of testosterone, and have long been under study for treating muscle-wasting and bone loss caused by certain medical conditions. None have been approved by the FDA, however, and the agency stresses that SARMs are drugs, not dietary supplements. Still, online companies are marketing SARM-containing products, with the help of social media. “Online vendors and social media influencers are using social media to make SARMs seem safe and effective,” the FDA said in its warning. Based on the reports the agency is receiving, that is far from the case: SARM-containing products are linked to sometimes life-threatening effects such as heart attacks, strokes and liver failure. Other side effects include testicular shrinkage, sexual dysfunction, fertility problems and even psychosis. The FDA has been warning consumers about the risks for years, and taken action against some companies that illegally market the products. But, experts said, because people are getting SARMs online from overseas companies, the problem is hard to tackle from the supply side. And from the consumer side, it may… read on > read on >

U.S. regulators are urging Americans to avoid Apetamin, an illegal drug used for weight gain and figure enhancement. The substance, typically sold as a syrup, is manufactured overseas, illegally imported and isn’t approved by the U.S. Food and Drug Administration. It contains a potent antihistamine called cyproheptadine, which requires a physician’s prescription in the United States. American consumers may find Apetamin online, on social media or in some retail stores, but they should not use it, the FDA warned in an agency news release. Among its dangerous side effects are potential overdose, sedation, cognitive impairment, dizziness, low blood pressure, disorientation and confusion, hallucinations, convulsions, and decreased breath and heart rates. It may lead to coma or death, the FDA said. The substance also decreases mental alertness, which may affect a person’s ability to drive a car or operate machinery. This strong antihistamine may be dangerously strengthened when taken with alcohol and other central nervous system depressants, such as hypnotics, sedatives, tranquilizers and anti-anxiety medications, the FDA said. Reports to the FDA’s Adverse Event Reporting System found young adults had taken Apetamin and experienced nervous system disorders, cardiac disorders and liver injury, the agency said. In one published report, someone who took Apetamin daily for six weeks developed autoimmune hepatitis. A chronic disease, this condition is treated with corticosteroids and immune system suppressors. It may cause… read on > read on >