Health/Fitness « Weekly Gravy

Much has been made of the so-called “obesity paradox” — the observation that people with a heart condition seem less likely to die if they are overweight or obese. But European researchers now say they’ve debunked that theory, which was based on earlier research that relied on body mass index (BMI, a measure based on weight and height) to judge whether a person carried excess weight. The major new study shows the obesity paradox vanishes if other heart risk factors are considered along with a person’s BMI. Further, researchers found that another measure of obesity, the waist-to-height ratio, more accurately reflected the real heart health risk that comes from having too much body fat. “Better measures of adiposity [excess fat] than BMI, such as waist-height ratio, eliminate the ‘obesity survival paradox’ and, indeed, show that greater adiposity is associated with a higher rate of hospital admission for worsening heart failure and worse symptoms and quality of life,” said senior researcher Dr. John McMurray, a professor of cardiology at the University of Glasgow. For this study, McMurray and his colleagues analyzed data from nearly 8,400 heart failure patients suffering from reduced ejection fraction, a condition in which the heart is not able to pump a normal amount of blood throughout the body. The patients were taking part in a clinical trial evaluating the safety and effectiveness… read on > read on >

(HealthDay News) – A drug-resistant bacteria linked to recalled eye drops has now killed three people. The U.S. Centers for Disease Control and Prevention reported Tuesday that infections with Pseudomonas aeruginosa had led to two additional deaths. In all, 68 people have become infected in 16 states. Eight of the patients have lost their vision. Four people have had to have their eyeballs removed. Three eye products have been recalled from Global Pharma Healthcare Private Limited in India. They were sold online, at stores and provided through ophthalmologist offices. While the P. aeruginosa strain involved in the recalls is resistant to 12 antibiotics, there may be new hope for treating it. Researchers at the University of California, San Diego, say they have identified a bacteriophage that has potential for working on the bacteria, CBS News reported. “Phage” treatments send viruses in to attack the drug-resistant bacteria. The university’s Center for Innovative Phage Applications has previously reported on therapies it developed to save patients with drug-resistant infections, CBS News reported. The center did not immediately respond to CBS News’ request for comment. It’s not known how many patients have been treated with the phage identified for this bacteria. In unrelated contamination incidents, two additional eye products from other manufacturers have been recently recalled, CBS News reported. More information The National Library of Medicine has more on… read on > read on >

Patients could soon have access to a new injectable drug to treat atopic dermatitis, the most common form of eczema. The drug, lebrikizumab, proved effective in teenagers and adults in two clinical trials just published in the New England Journal of Medicine. “Across both of these pivotal studies for atopic dermatitis, lebrikizumab was highly effective, with a subset of patients responding quite early and then experiencing very durable responses up until week 16 in the initial phase of the study,” said lead researcher Dr. Jonathan Silverberg. He is an associate professor of dermatology at George Washington University School of Medicine & Health Sciences in Washington, D.C. Subsequent data has shown a good response among patients out to a year, he added. Based on these results, the U.S. Food and Drug Administration could approve lebrikizumab within a matter of months, Silverberg said. “We’re hoping that by mid-2023 that this will be FDA-approved and available to us to use, which is very exciting to have another highly effective option on the horizon,” he said. Lebrikizumab is an injectable monoclonal antibody designed to target interleukin-13, a biochemical expressed by immune cells that promotes an inflammatory response in the body. “It increases inflammation within the skin. It can increase or amplify the sensation of itch,” Silverberg said of interleukin-13. “And it also can lead to disruption of the skin… read on > read on >

If you bought a carbon monoxide detector on Amazon and it was sold under the names GLBSUNION and CUZMAK, stop using it. The U.S. Consumer Protection Safety Commission issued a warning because these detectors may fail to alert consumers to the presence of deadly CO, which is odorless and colorless. The detectors have a digital display. More than 200 people in the United States die every year from accidental, CO poisoning associated with consumer products. If an elevated level of the deadly gas is in the home and the detector isn’t working, injury or death are likely, CPSC noted. Sensitivity tests performed by the commission on the GLBSUNION and CUZMAK detectors found that they failed to alert when exposed to predetermined concentrations of CO in the amount of 400 ppm. This is a violation of UL 2034, a voluntary safety standard, the commission said in a statement. The CO detectors in the warning are made of white plastic, with approximate dimensions of 4 by 1.5 by 4 inches. The devices are advertised to detect dangerous levels of carbon monoxide and alert with a flashing red LED and a loud alarm pattern. The items sold on Amazon for between $16 and $40. Model No. AJ-938 was sold under the Amazon ASIN B093Y1KK5Q and B093Y637CM. Model No. CD01 was sold under the Amazon ASIN B07MPVK6HG and B07K44HLCV.… read on > read on >

Wildfires are known to have a lot of negative impacts on the environment and the health of the people who live through them. Yet another is the worsening of skin conditions, according to the American Academy of Dermatology (AAD). The group shared strategies to minimize the effect air pollution can have on people’s skin during its annual meeting, held this past weekend in New Orleans. “The health impact of air pollution from wildfires has not been well studied, but the evidence from our recent studies suggests that short-term exposure to wildfire air pollution can affect the skin and cause flares of certain skin disorders,” said Dr. Maria Wei, a professor of dermatology at the University of California, San Francisco. “We found that the air pollution from California wildfires were associated with an increase in patient visits to dermatologists for both eczema and psoriasis,” Wei added in an AAD news release. “These results are consistent with studies indicating that air pollution from wildfires can be more toxic than air pollution caused by traditional industrial and traffic sources.” Psoriasis happens when the body makes skin cells too quickly, causing them to pile up and form patches on the skin. Eczema is inflamed, itchy, irritated skin. People with the skin condition eczema were more likely to visit dermatologists during the wildfires. Those with psoriasis were more likely to… read on > read on >

As the weather warms, folks are bringing out their bicycles for a ride. That’s great, but it’s important to be ready for a safe biking season: The national rate of bike accidents is two fatal crashes and 2,630 accidents requiring emergency room visits every week. Angela Mountz, community car seat safety program coordinator at Penn State Health Children’s Hospital in Hershey, offers some tips for parents to help their young cyclists avoid serious childhood riding accidents. “I had a cousin who was hit by a car [while on a bike],” Mountz said in a hospital news release. Mountz’s cousin didn’t die, but suffered from the injuries for the rest of his life. “Kids go around thinking, ‘It’s not going to happen to me,’” she said. “But it’s so important to protect yourself.” A helmet is at the very top of her list. The odds that a child will suffer a serious injury if involved in a crash while biking go up 40% if they’re not wearing a helmet, Mountz said. Parents should also wear a helmet while riding: “We need to teach them by example,” Mountz said. Aim for safety over style, Mountz added. Look for a sticker from the American National Standards Institute or the Snell Memorial Foundation to be sure your child’s helmet is certified. Check your kids’ helmets every two months to… read on > read on >

Considered one of the most common sexually transmitted diseases, chlamydia can spread easily and often without obvious symptoms. And although chlamydia cases have declined in recent years, the U.S. Centers for Disease Control and Prevention chalks that up to reduced screening for sexually transmitted diseases (STDs) during the pandemic. It is estimated that 1 in 20 sexually active women between the ages of 14 and 24 gets chlamydia, according to the American Sexual Health Association (ASHA). The side effects of untreated infection are significant, per the CDC: Chlamydia can permanently damage a woman’s reproductive system, and can also cause a potentially fatal ectopic pregnancy (one that occurs outside the womb). What is chlamydia? Chlamydia is a bacterial infection that can be treated effectively if caught early, according to the Mayo Clinic. Often, it is symptom-free, making it easy to spread before someone realizes they have it. Between 50% and 70% of those who catch it don’t know they’ve caught it — a fact that has earned chlamydia the nickname of the “silent infection.” Research published recently in the Journal of Adolescent Health found that an opportune time to screen young women for chlamydia would be when they get long-acting birth control from their doctors. Is chlamydia curable? Because it is a bacterial infection, chlamydia is curable with antibiotics when caught early, according to the Cleveland… read on > read on >

A gene-editing experiment that restored the vision of mice might one day be used to treat a major cause of human blindness. Scientists in China reported they used the CRISPR-based gene-editing technique to bring back vision in mice with retinitis pigmentosa. Genome editing has previously been used to restore the vision of mice with genetic diseases such as Leber congenital amaurosis, which affect a layer of cells in the eye that supports the light-sensing rod and cone photoreceptor cells. Most of these conditions are caused by genetic defects in the photoreceptors themselves. “The ability to edit the genome of neural retinal cells, particularly unhealthy or dying photoreceptors, would provide much more convincing evidence for the potential applications of these genome-editing tools in treating diseases such as retinitis pigmentosa,” said researcher Kai Yao, a professor at Wuhan University of Science and Technology. For the study, Yao’s team set out to restore the vision of mice with retinitis pigmentosa caused by a flaw in a gene encoding a critical enzyme called PDE6B. For the task, they developed a more versatile CRISPR system called PESpRY. It can be programmed to correct many types of genetic mutation, no matter where they occur within the genome. When programmed to target the mutant gene, PESpRY efficiently corrected the mutation, according to the study. It restored the enzyme’s activity in the retinas… read on > read on >

Many patients worry that receiving a metal implant might set off their metal allergy, according to the American Academy of Dermatology. “Cases in which patients are inquiring about a metal allergy as it relates to their metal implants — including joint replacements, rods, pins, screws, plates, certain neurologic and cardiac devices such as pacemakers, and dental devices — are becoming more prevalent as medical implants become more common,” said Dr. Golara Honari, a clinical associate professor of dermatology at Stanford School of Medicine. About 10% of Americans will receive a medical implant during their lifetime. Millions of people in the United States report having a metal allergy. Metal, especially nickel, is one of the most common causes of allergic contact dermatitis, Honari said. It develops when skin is exposed to an allergen, often leading to a rash and itching. Other symptoms can include dryness, hives, blisters or pain. Honari noted that suspected metal implant allergies can be difficult to diagnose because everyone’s immune system reacts to allergens differently. Close collaboration between a dermatologist and the surgeon or physician who placed the implant is essential, she said. Patients who need an implant and have a documented history of a metal allergy should notify their dermatologist and physician or surgeon about any allergies prior to the procedure. Alternatives to metal implants are available. “For example, if it’s… read on > read on >

It’s well-established that American football players can suffer significant brain impacts as they age. Now, new research shows that elite European soccer players are also more likely than the average person to develop dementia. Men in the Swedish top soccer division between 1924 and 2019 were 1.5 times more likely to develop neurodegenerative disease than those in a control group. The study of more than 6,000 players found they had an increased risk of developing Alzheimer’s disease and other dementias. They did not, however, have any increased risk for motor neuron disease, such as amyotrophic lateral sclerosis (also known as ALS, or Lou Gehrig’s disease). And they had even lower risk of Parkinson’s disease than a control group matched by age, sex and region. Unlike their outfield counterparts, goalkeepers did not have an increased risk of dementia. This supports the theory that heading the ball increases the risk, according to the report published March 16 in The Lancet Public Health. “Goalkeepers rarely head the ball, unlike outfield players, but are exposed to similar environments and lifestyles during their [soccer] careers and perhaps also after retirement,” said Dr. Peter Ueda, an assistant professor at Karolinska Institute in Sweden. “It has been hypothesized that repetitive mild head trauma sustained through heading the ball is the reason [soccer] players are at increased risk, and it could be that… read on > read on >