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Many men have likely never heard of Peyronie’s disease, but they might want to brush up on this condition because it causes the penis to curve abnormally during an erection. Peyronie’s disease typically affects men over 30, and it appears to be caused by the build-up of plaque in the tunica albuginea. The tunica albuginea is the inner lining of the penis, and it helps the penis remain stiff during an erection. Here, experts will explore what Peyronie’s disease is, its causes, symptoms and how it can be treated. What is Peyronie’s disease According to the National Institutes of Health (NIH), Peyronie’s disease can develop when there is a physical injury to the penis, scar tissue forms, and the hard plaque that can build on scar tissue pulls on the surrounding tissue of the penis and causes a curve, usually when the penis is erect. In a patient page provided by the Journal of the American Medical Association, Dr. Christopher Gaffney and Dr. James Kashanian, both urologists at New York-Presbyterian Hospital in New York City, state that “Peyronie’s disease can cause pain (with or without erections), inability to engage in penetrative sexual intercourse, erectile dysfunction, emotional distress, depression and relationship difficulties. It develops in up to 5% to 10% of men.” Peyronie’s disease versus normal curvature The Cleveland Clinic uses the analogy of a clock… read on > read on >