Made infamous as the club drug Special K, ketamine is nowadays being seen as a wonder drug for some folks with hard-to-treat depression. However, a new study finds that some types of patients are more likely to gain a rapid and significant benefit from ketamine than others. Overall, while most patients did benefit from the drug, about one-third experienced a “rapid improvement” in their depression symptoms, the researchers said. Certain patient characteristics appeared to predict that level of benefit. “Severely depressed individuals with a history of childhood trauma may have a better likelihood of a rapid and robust response to ketamine,” concluded lead researcher Brittany O’Brien, an assistant professor of psychiatry and behavioral sciences at Baylor College of Medicine in Houston. In 2019, the U.S. Food and Drug Administration approved a ketamine derivative called esketamine (Spravato) for depression that has failed to respond to at least two conventional antidepressants. Given as a nasal spray, esketamine is different from ketamine, which is an injectable anesthetic that can have mind-altering effects. The new study included nearly 300 people with major depression who were treated with three infusions of ketamine at an outpatient clinic. Participants were 40 years old, on average, and most were men. They had not responded to at least two antidepressants in the past. Mood changes were measured using a standardized depression scale over six…  read on >  read on >

Being evicted can have a significant impact on a person’s health, according to new research. In U.S. counties where eviction rates were elevated, death rates were higher for all causes, especially if those areas were home to a higher proportion of Black residents and women. Study author Dr. Andrew Sumarsono, assistant professor of internal medicine at University of Texas Southwestern Medical Center in Dallas, said this study was the first to evaluate and identify a link between county eviction and death rates. “Affordable, stable housing is a public health concern. If you’re worried about where you’re going to live next week, caring about your health can easily become a lesser priority,” Sumarsono said in a center news release. “Policies that increase affordable housing and cushion against life events that lead to housing instability could translate to better health outcomes.” To study this, researchers analyzed both eviction rates and deaths in nearly 700 U.S. counties using data from 2016. In counties where the proportion of women was above the median (meaning half had fewer, half more), death rates were five times higher than in counties with a lower proportion of women. Although death rates in areas with a higher proportion of Black residents were also higher, just 2% of those in the study were Black so the findings may be limited, researchers said. The county data…  read on >  read on >

While 8 of 10 mothers breastfeed their newborns for a short time, the number plummets despite recommendations from experts, in part because milk production falls off. Researchers investigating why that happens found that in women who are obese, inflammation may be the culprit. Prior research has shown that when a person is obese, chronic inflammation starts in the fat and spreads to organs and systems throughout the body. And that inflammation may disrupt absorption of fatty acids from the blood into body tissues. These fatty acids are the building blocks for the fats needed to feed a growing infant. “Science has shown repeatedly that there is a strong connection between the fatty acids that you eat and the fatty acids in your blood,” said lead author Rachel Walker, postdoctoral fellow in nutritional sciences at Penn State University. “If someone eats a lot of salmon, you will find more omega-3s in their blood. If someone else eats a lot of hamburgers, you will find more saturated fats in their blood.” The study is among the first to examine whether fatty acids in blood are also found in breast milk, Walker said. “For women who are exclusively breastfeeding, the correlation was very high; most of the fatty acids that appeared in blood were also present in the breast milk,” she said in a university news release. But…  read on >  read on >

Living in tight-knit communities where neighbors are connected to one another helped improve health outcomes for older Chinese Americans, a new study found. Rutgers University researchers used data from a study of more than 3,100 elderly Chinese people in the Chicago area to investigate whether the perception of trust and connection among neighbors had an impact on their risk of death. The study found folks who lived alone and reported low interaction or connection with neighbors had a 48.5% higher risk of premature death than those who lived with someone else. However, participants who lived alone but had strong neighborhood ties had a similar risk of death compared to those with housemates. The presence of helpful neighbors seemed to make a difference, researchers said. “Older Chinese Americans who lived by themselves in neighborhoods with low cohesion were much more likely to die earlier than those who lived by themselves in neighborhoods with strong cohesion,” said study author Yanping Jiang, an instructor at the Rutgers Institute for Health, Health Care Policy and Aging Research in New Brunswick, N.J. About 27% of people ages 60 and up in the United States live alone, according to Pew Research Center. Living alone has been linked to depression, heart disease, dementia, poor biological health and premature death. Social policies can help create better neighborhood environments for promoting health of older…  read on >  read on >

It’s a scenario no parent would ever want to witness: Their child suffers a mental health crisis and is taken to the emergency room, only to have to wait 12 hours or more for the right medical care. Sadly, it is what 1 in 5 of these young patients now face, new research finds. “For kids with mental health conditions, long waits in the emergency department have been a compounding problem for decades,” said lead researcher Dr. Alexander Janke, a visiting research scientist at Yale University Medical School in New Haven, Conn. The long waits are a symptom of a larger problem: Between numerous bottlenecks in the mental health care system and poor access to counseling services in settings like clinics and schools, “the system we have built to take care of some of our most vulnerable children is not adequately resourced,” Janke said. For the study, Janke and his colleagues turned to data from the American College of Emergency Physicians Clinical Emergency Data Registry. The researchers looked specifically at 107 emergency departments in 29 states from January 2020 through December 2021. The investigators found that the rate of visits where a child stayed longer than 24 hours more than doubled in some months during the pandemic. According to the report, kids who remained in the emergency department for more than 24 hours accounted for…  read on >  read on >

For people with heart disease, new research suggests loneliness, social isolation and living alone can shave years off your life. This trio puts people with established cardiovascular disease at greater risk of premature death, according to the international study. Cardiovascular disease refers to heart disease and stroke. “Social health factors such as loneliness and social isolation have gained a significant amount of attention recently and are really important to think of within the context of cardiovascular health,” said lead author Róisín Long, a clinical psychologist and a doctoral candidate at University of Limerick in Ireland. “What was unclear is to what degree they impact how long people live when they have been diagnosed with cardiovascular disease,” Long said in a university news release. “Our review found that each of these factors are critically important to consider in the treatment of cardiovascular disease, as increased levels of loneliness, social isolation and living alone appears to lead to premature death,” Long added. There are likely several reasons for this, Long added, ranging from support from another person to how an individual biologically responds to stress. For the report, researchers reviewed 35 studies done in Europe, North America and Asia over many decades. The effects of living alone appeared stronger in European countries. This may be a reflection of the large number of people living alone in parts…  read on >  read on >

U.S. communities with higher Hispanic, American Indian or Black populations also have the highest concentrations of metal in public water systems, new research reveals. Researchers from Columbia University Mailman School of Public Health in New York City found significantly higher arsenic and uranium levels in public drinking water in Hispanic and American Indian/Alaska Native communities nationwide, as well as in Black communities in the West and Midwest. These areas have more arsenic and uranium. The researchers said this study could be done now only because estimates of contaminant concentrations are finally available for the majority of public water systems. “Our findings are particularly relevant to public health because there is no safe level of exposure to inorganic arsenic and uranium,” said first study author Dr. Irene Martinez-Morata, a PhD candidate in environmental health sciences. “These findings support that inequalities in public water contaminant exposures are more severe in regions with more residents from communities of color relying on public drinking water and higher concentrations of specific contaminants in source water,” she explained in a university news release. Arsenic and uranium exposure are associated with cancer, heart disease and other adverse health outcomes. The U.S. Environmental Protection Agency (EPA) sets a maximum contaminant level of 30 µg/L for uranium and 10 µg/L for arsenic. But its non-enforceable goal for both metals is 0 µg/L, because there…  read on >  read on >

TUESDAY, Dec. 27, 2022Living in an area with easy access to parks and rivers appears to slow the progression of devastating neurological diseases, such as Alzheimer’s and Parkinson’s. That’s the conclusion of a new study based on more than a decade and a half tracking disease risk among nearly 62 million Americans 65 years old and up. “Prior research showed that natural environments — such as forests, parks and rivers — can help to reduce stress and restore attention,” noted lead author Jochem Klompmaker, a postdoctoral research fellow at Harvard T. H. Chan School of Public Health in Boston. “In addition, natural environments provide settings for physical activity and social interactions, and may reduce exposure to air pollution, extreme heat and traffic noise.” To build on such observations, his and his colleagues looked at hospital admissions for Alzheimer’s and related dementia, as well as Parkinson’s disease. By focusing on hospital admission, Klompmaker stressed that his team was not assessing the initial risk for developing either disease. Instead, researchers wanted to know if increased exposure to nature lowered the odds that either disease would progress quickly. And on that front, Klompmaker said, researchers observed significant protective links: The greener an older individual’s surrounding environment, the lower their risk of hospitalization for either neurological illness. The finding could have bearing on millions of Americans, given that Alzheimer’s…  read on >  read on >

Stress is rarely a good thing for your health, but new research warns that it significantly raises the risk of a stroke. The study found that increased stress at home or work and recent stressful life events — like getting divorced or a major family conflict — were associated both with increased risk of stroke due to a clot, known as an ischemic stroke, and a stroke due to bleeding in the brain, called a hemorrhagic stroke. What to do to lower that risk? “Optimal approaches to managing, and preventing, psychosocial stress are uncertain. Previous studies have looked at interventions such as cognitive behavioral therapy, relaxation techniques, client-led discussion, stress management, exercise regimens and anger management,” said study author Dr. Catriona Reddin, of the University of Galway College of Medicine, Nursing and Health Sciences, in Ireland. “The most effective approach may vary from person to person. It’s important that everyone has a strategy that works for them,” Reddin said. Her team studied stress around the world using data from a retrospective study known as INTERSTROKE in more than 26,000 people in 32 countries in North and South America, Africa, Asia, Europe, Australia and the Middle East. People who had severe work stress were more than twice as likely to have an ischemic stroke as those with no work stress, the investigators found. They were more…  read on >  read on >