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Black people are five times as likely as others to develop glaucoma and up to 15 times more likely to be blinded by the degenerative eye disease. Now, a new study reports that genetics appears to be at least one factor contributing to this increased risk. Researchers have identified three gene variants that could be fueling Black people’s higher glaucoma risk, according to findings published Jan. 18 in the journal Cell. “Our work is an important step toward defining subgroups of glaucoma, providing the capability for early screening and discovering targetable pathways for personalized therapeutic interventions,” said study co-author Rebecca Salowe, a research project manager with the University of Pennsylvania’s Center for Genetics of Complex Disease in Philadelphia. Glaucoma occurs when fluid pressure starts to increase inside a person’s eye, gradually damaging the optic nerve. For the study, researchers analyzed the genetics of more than 11,200 people of African ancestry. They discovered two gene variants linked to primary open-angle glaucoma, which is the most common form of the disease. Open-angle glaucoma affects as many as nine out of 10 Americans who have glaucoma, according to the Cleveland Clinic. It occurs when resistance builds up in the canals that typically drain excess fluid from the eye. They also found a third variant associated with cup-to-disc ratio, which is a measure of glaucoma severity based on the… read on > read on >