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A class of sedatives called benzodiazepines, which include meds like Ativan, Valium and Xanax, could be linked to higher odds for miscarriage if taken during pregnancy, new research finds. The findings held even after accounting for possible confounding factors such as anxiety and insomnia, the Taiwanese research team said. Looking at data on about 3 million pregnancies, “we found that benzodiazepine use during pregnancy was associated with an approximately 70% increased risk of miscarriage,” wrote a team led by Fei-Yuan Hsiao at Taiwan University’s Graduate Institute of Clinical Pharmacy. Based on the findings, they urge that doctors “meticulously balance” the risks and benefits of benzodiazepines whenever they consider prescribing the drugs to pregnant women who are dealing with insomnia or other psychiatric issues. In the new study, miscarriage was defined as loss of pregnancy between the first prenatal visit with a doctor (typically around the 8th week of gestation) and before the 20th week. Hsiao’s group looked at data from over 3 million pregnancies among Taiwanese women, out of which 4.4% resulted in a miscarriage. Focusing on the women’s prescription drug use during pregnancy, the study found that using a benzodiazepine boosted the odds for miscarriage by 69%. That number was “consistent” regardless of confounding factors and the duration of benzodiazepine use. The study was published Dec. 27 in the journal JAMA Psychiatry. Hsiao’s group… read on > read on >