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Folks who take the blockbuster weight-loss med tirzepatide (Zepbound) may regain much of the weight they lost soon after discontinuing it, new research shows. A trial funded by Eli Lilly, the injected drug’s maker, found that “in patients with obesity or overweight, withdrawing tirzepatide led to substantial regain of weight.” On the other hand, continuing on with tirzepatide kept the weight off, over the full two years of the trial. Of course, sticking with drug could mean big bills for users. Medicare and Medicaid do not cover the drug, and if your private insurance doesn’t cover Zepbound, it can cost over $1,000 per month. Lilly says certain commercial card savings programs it offers can reduce the monthly cost to about $550, or even lower, however. Zepbound was approved for weight loss by the U.S. Food and Drug Administration on Nov. 8, and Lilly announced its availability to consumers on Dec. 6. To trigger weight loss, tirzepatide mimics two hormones, GLP-1 and GIP, which stimulate the release of insulin in the body. It quells appetite and slows the rate at which food moves through the stomach, helping patients feel full. It’s the first drug in its class to compete with another weight-loss blockbuster, Wegovy. Wegovy, made by Novo Nordisk, uses a similar active ingredient, semaglutide, which only focuses on GLP-1. That difference appears to translate to… read on > read on >

Chronic fatigue syndrome strikes more Americans than many might think: In a first national estimate, new government data puts that number at 3.3 million. The condition clearly “is not a rare illness,” and is being fueled in part by patients who now suffer from long COVID, report author Dr. Elizabeth Unger, chief of the chronic viral diseases branch at the U.S. Centers of Disease Control and Prevention, told the Associated Press. In reality, that count could be even higher, because experts believe only a fraction of the people with chronic fatigue syndrome are ever diagnosed, said Dr. Daniel Clauw, director of the University of Michigan’s Chronic Pain and Fatigue Research Center. “It’s never, in the U.S., become a clinically popular diagnosis to give because there’s no drugs approved for it,” he told the AP. “There’s no treatment guidelines for it.” Further clouding the picture, the tally likely included some patients with long COVID who were suffering from prolonged exhaustion, CDC officials said. Long COVID is defined as chronic health problems that persist for weeks, months or years after a COVID infection. Symptoms can vary, but patients often complain of the same symptoms seen in people with chronic fatigue syndrome. “We think it’s the same illness,” Dr. Brayden Yellman, a specialist at the Bateman Horne Center in Salt Lake City, told the AP. But long COVID is more accepted… read on > read on >

Loss of the “happiness” brain hormone serotonin might play a role in the decline of brain function as a person ages, a new study reports. People with mild cognitive impairment (MCI) had up to 25% lower levels of serotonin than healthy people in key regions of the brain associated with memory, problem-solving and emotion, researchers reported recently in the Journal of Alzheimer’s Disease. Those patients also had higher levels of amyloid beta, a protein that forms toxic clumps in the brains of Alzheimer’s patients, the researchers added. “The correlation we observed between lower serotonin transporters and memory problems in MCI is important because we may have identified a brain chemical that we can safely target that may improve cognitive deficits and, potentially, depressive symptoms,” said researcher Gwenn Smith, a professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine in Baltimore. “If we can show that serotonin loss over time is directly involved in the transition from MCI to AD [Alzheimer’s disease], recently developed antidepressant medications may be an effective way to improve memory deficits and depressive symptoms and thus, may be a powerful way forward to slow disease progression,” Smith added in a Hopkins news release. For this study, researchers recruited 49 volunteers with mild cognitive impairment and 45 healthy adults aged 55 and older to undergo brain scans. The… read on > read on >

Sore throats are commonplace during cold and flu season, but luckily there are lots of home remedies that can help ease your misery, doctors say. These remedies “aren’t quick fixes for an illness,” but they can help ease discomfort, said Dr. Heidi Hutchison, a family practice physician at Penn State Health Medical Group – East Pennsboro. . Folks with a sore throat should still get checked out by a doctor, to make sure they aren’t sick with strep throat or some other illness for which there are prescription meds, Hutchison said. But for a simple sore throat, these tried-and-true remedies can soothe just as well as cough drops or other store-bought cold treatments, Hutchison said. Honey Honey is a natural anti-inflammatory, and is used in countries like Croatia as a medicine rather than a sweetener, Hutchison noted. Most of the time, inflammation is what’s causing your throat to hurt. Your body is trying to rid itself of an infection in the back of your throat, which causes your throat to swell and feel scratchy. Honey is also safe for most people from age 1 and up, Hutchison added. Tea Certain kinds of herbal tea like chamomile also have anti-inflammatory properties, Hutchison said. Sweetening it with honey can provide a one-two punch to a sore throat. The warmth of hot tea also can be soothing to a… read on > read on >

Suicide rates for Black women and girls ages 15 to 24 have more than doubled over the past two decades, a new report finds. “Suicides are rapidly increasingly among young, Black females in the U.S.,” said study first author Victoria Joseph, an analyst in the department of epidemiology at Columbia Mailman School of Public Health in New York City. Her team published their findings recently in the American Journal of Psychiatry. Suicide has been on the rise generally across the United States for many years. Data released in late November by the U.S. Centers for Disease Control and Prevention found that almost 49,500 people lost their lives to suicide in 2022. That’s a 3% rise from the nearly 48,200 deaths recorded in 2021. Joseph’s team found that young Black females are no exception to this trend. They looked at 1999-2020 data from the CDC’s National Center for Health Statistics database, which tracked causes of deaths for Americans. In 1999, 289 Black females aged 15 to 84 died by suicide; by 2020 that number had risen to 652. The year 2010, especially, seemed to be “an inflection point for subsequent increases in suicide deaths,” Joseph noted. There was also a “clear age effect,” the researchers said, with suicide rates rising higher among younger Black females. The overall rate of suicide among Black females rose from 2… read on > read on >

The Biden administration has again delayed enacting a ban on menthol cigarettes following intense lobbying from the tobacco industry. Along with that pressure, other critics of the ban have warned that it might anger Black smokers, who use menthol cigarettes at far higher rates than whites — just as President Biden gears up to run for re-election, administration officials told the Washington Post. The delay, which was posted Wednesday, now says officials plan to finalize rules to put the ban in place in March. Officials had originally planned to finalize the rules last August and later signaled to public health groups that they hoped to finish them by January, the Post reported. Still, the ban would not likely go into effect for several years because of the legal challenges that many expect will come. But anti-smoking advocates aren’t waiting to push passage of the ban. Karen Knudsen, chief executive of the American Cancer Society, said her organization is among a coalition of public health associations that this month will take out ads in national newspapers, send letters to lawmakers and use other measures to push the Biden administration to finalize the rule sooner rather than later. “The cost of inaction is high,” Knudsen told the Post, citing projections that a ban on menthol cigarettes would save up to 650,000 lives over the next four decades. Many of the lives… read on > read on >

Games like football, soccer and rugby come to mind when thinking about sports-related concussions. But a smashing tennis shot could cause a traumatic brain injury if the ball whacks a player’s head, a new study argues. Concussions can happen if a tennis ball traveling faster than 89 miles per hour hits someone on the head, researchers report. The average serve speed in professional tennis often exceeds 100 mph for both men and women, according to the website TennisUniverse. Amateur players can’t hit the ball nearly as hard as that, but tennis ball injuries are possible, if rare, even among amateurs, the researchers said. “Understanding and protecting against head injuries induced by tennis ball impacts is very important, given that tennis is a worldwide sport with tens of millions of participants every year,” said researcher Xin-Lin Gao, a mechanical engineering professor at Southern Methodist University in Dallas. Head injuries from a tennis ball is also more likely if the ball strikes the side of the head or if it strikes at a direct 90-degree angle, Gao and colleagues reported recently in the Journal of Applied Mechanics. The researchers came to their conclusions using a computer model similar to that which predicts head injuries that might occur in a car accident. The computer model assessed what might happen to a man’s head if hit by a tennis… read on > read on >

“Forever” PFAS chemicals appear to harm bone health in Hispanic teenagers, a new study finds. The more PFAS chemicals found in the bodies of Hispanic adolescents, the lower their bone density was, researchers report in the Dec. 6 issue of the journal Environmental Research. Peak bone mineral density in adolescence helps predict whether a person will develop osteoporosis later in life, University of Southern California researchers noted. “Many existing studies haven’t included participants this young, but we’re now able to see that this association is already happening at a time when bones are supposed to be developing,” said lead researcher Emily Beglarian, a doctoral student in the Department of Population and Public Health Sciences at USC’s Keck School of Medicine. Per- and polyfluoroalkyl substances (PFAS) are used in a wide range of consumer products, and also are widely present in drinking water and the environment. They are called “forever chemicals” because of their carbon and fluorine molecules, one of the strongest chemical bonds possible. PFAS have been linked to reproductive problems and increased cancer risk, while a growing body of evidence has also tied the chemicals to lower bone mineral density, researchers said. But those studies have focused mainly on older whites. This research team decided to see whether the same risk holds in young Hispanics, a group that faces a heightened risk of bone… read on > read on >

In a win for telemedicine, new research shows that folks fighting high cholesterol benefit just as much from online coaching as they do from in-person visits with a dietitian. “This study reinforces the idea that comparable clinical outcomes can be achieved using the virtual format,” said lead researcher Dr. Shannon Zoulek, a resident physician at University of Michigan Health. “Improving cholesterol levels may reduce cardiovascular events, and having additional options to access treatment will benefit patients who seek treatment,” Zoulek added in a Michigan news release. More than 20% of American adults are currently using telemedicine, taking their health appointments online rather than traveling to an office, the researchers said in background notes. For the study, the investigators tracked more than 250 patients seen by a registered dietitian between early 2019 and late 2022 at the Preventative Cardiology Clinic of the University of Michigan’s Frankel Cardiovascular Center. Around one in five patients opted for a virtual visit, while the rest had face-to-face visits with their dietitian, the researchers said. Patients who received this diet coaching experienced significant declines in their “bad” LDL cholesterol and triglycerides, both of which decrease the risk of heart disease. In the end, the researchers found no significant difference in results between telemedicine and in-person visits. The new study was published recently in the Journal of Clinical Lipidology. “Access to nutrition… read on > read on >

Exercise can boost the quality of life of women who are battling advanced breast cancer, a new study has found. Women who took part in a nine-month structured exercise program reported less fatigue and a better overall quality of life, according to results presented Thursday at the San Antonio Breast Cancer Symposium. “Optimizing quality of life is, of course, important for everybody, but especially for patients living with metastatic disease who undergo continuous treatment,” said researcher Anne May, a professor at the Julius Center for Health Sciences and Primary Care at the University Medical Center, Utrecht, in the Netherlands. “By improving quality of life through enhanced symptom management, we can help patients better enjoy their personal, social, and, if applicable, working life,” May added in a meeting news release. Previous studies have found that exercise can help people with less advanced cancers, but whether those benefits also apply to patients whose cancers have spread has not been rigorously tested, May noted. For the study, May and her colleagues enrolled 357 people with advanced breast cancer, in a collaboration between institutions in Germany, Poland, Spain, Sweden, the Netherlands and Australia. All participants received a physical activity tracker and generic exercise advice. But 178 patients were also randomly selected to receive more help – twice-weekly supervised exercise sessions for nine months that involved balance, resistance and aerobic… read on > read on >

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Pounds Return Once Zepbound Users Quit the Weight-Loss Drug: Study

Over 3 Million Americans Struggle With Chronic Fatigue Syndrome

Brain Serotonin Levels May Play Role in Alzheimer’s Onset

Sore Throat? Try These 5 Home Remedies for Relief

Suicide Rates Have Risen Steadily for Black Girls and Women

Biden Administration Delays Decision on Menthol Cigarette Ban Amid Pushback

Tennis Ball Impacts Can Also Cause Concussions

PFAS Chemicals May Harm Bones of Hispanic Teens

Watching Your Cholesterol? Virtual Doctor Visits Work Just as Well

Exercise Brings Better Quality of Life to Women With Advanced Breast Cancer