The potential health benefits of GLP-1 diabetes and weight loss meds keep piling up: New research shows they may also shield your kidneys from harm. In the largest study to date on the effects of the drugs on the kidneys, researchers found GLP-1s help the protect the organs in people with or without diabetes. GLP-1s include blockbuster diabetes medicines such as Ozempic and its weight-loss spinoff, Wegovy. “This is the first study to show a clear benefit of GLP-1 receptor agonists on kidney failure or end-stage kidney disease,” said study lead author Dr. Sunil Badve, a kidney specialist and professorial fellow at The George Institute for Global Health in Sydney, Australia. The study suggests that GLP-1s “have a key role in kidney-protective and heart-protective treatment for patients with common medical conditions like type 2 diabetes, overweight or obesity with cardiovascular disease, or chronic kidney disease,” he said in a news release. The research was published Nov. 25 in The Lancet Diabetes & Endocrinology. Badve and colleagues conducted what’s called a meta-analysis — a large review of data from multiple studies, in this case 11 large-scale clinical trials of GLP-1s involving more than 85,000 people in all. Close to 68,000 had type 2 diabetes, while just over 17,600 were overweight or obese with heart disease but did not have type 2 diabetes. The GLP-1 medicines taken… read on > read on >
A little about: Weekly Gravy
All Sauce from Weekly Gravy:
Preschoolers’ Tantrums Can Be Early Sign of ADHD
Preschoolers prone to tantrums appear to have a higher risk of attention-deficit/hyperactivity disorder (ADHD) by the time they reach school age, a new study says. Young children who struggle to control their emotions and behavior have more ADHD symptoms by age 7, researchers found. Their conduct is more likely to be poor and they are more apt to suffer from emotional problems like sadness or worry by that age, results show. “Emotion regulation skills are acquired from early in life and are thought to strengthen gradually over childhood,” lead researcher Aja Murray, a lecturer in psychology with the University of Edinburgh in the U.K., said in a news release. “Children, however, acquire these skills at different rates and slower acquisition may serve as a marker for neurodevelopmental and mental health issues.” For the study, researchers analyzed data on roughly 19,000 young people born between 2000 and 2002 in the U.K. Results showed that ADHD symptoms are significantly associated with a child’s tendency to have extreme emotional responses and slower development of their ability to regulate those emotions, researchers said. The less able children were able to manage their emotions, the greater their risk for ADHD, results show. This association held even after other risk factors for ADHD and mental health problems were taken into account, researchers said. Based on these results, early testing might be… read on > read on >
Supreme Court Won’t Hear Big Tobacco’s Challenge to Cigarette Warning Labels
The U.S. Supreme Court on Monday declined to hear a major tobacco company’s challenge to a federal law that would mandate graphic images on cigarette packs. Some of the proposed images include a woman with a large lump on her neck alongside the message “WARNING: Smoking causes head and neck cancer;” lungs blackened by smoking; and feet darkened by smoking-linked circulatory problems. The R.J. Reynolds tobacco company had filed an appeal with the Supreme Court after the 5th U.S. Circuit Court of Appeals ruled that the warnings do not violate the First Amendment, the Associated Press reported. In its appeal, the tobacco company argued that some of the images were misleading — for example, the company claimed that the woman with the lump on her neck would never have let it get that large before going to a doctor. But the Supreme Court justices ruled that the images do, in fact, reflect the very real hazards of smoking. If the images make it to the sides of cigarette packs, the U.S. would join 120 other nations that already mandate such graphic warnings. Studies have shown that images work even better than text warnings in cutting down smoking rates. In a statement, the Campaign for Tobacco-Free Kids called the Supreme Court’s dismissal of the appeal a “tremendous victory for public health.” “Graphic warnings are a best-practice policy to… read on > read on >
T-Day Dinner, Post-Election: Experts Offer Tips to Keep Things Calm
Politics, especially the 2024 elections, can quickly turn the family Thanksgiving table into a battleground. Steering clear of hot-button topics will not only help a big meal go down easier, it has health benefits as well. Keeping the peace prevents a surge of fight-or-flight hormones that can disrupt sleep and cause headaches, inflammation and even shortness of breath, according to UT Southwestern colleagues Cameron Davis, an assistant professor of psychiatry, and Sarah Woods, vice chair of research in the Department of Family and Community Medicine. They assure folks that it is possible to stay calm and enjoy yourself this Thanksgiving, even in a house divided. Here are their do’s and dont’s for reducing stress this Thanksgiving: Do communicate respectfully: Avoid personal attacks and keep the conversation focused on facts and objectives. Be assertive, not aggressive. Don’t feel pressured to engage in emotionally charged talk: Politely state your desire to not take part in political discussions — or change the topic. Don’t push family members’ buttons. Do be prepared: Practice how you will handle it if conversation gets stressful and how you’ll behave toward individuals. Don’t pressure others into a debate or insist they agree with your views: Focus on fostering respectful dialogue. Asking for permission or gauging others’ willingness to discuss a topic can help head off tense encounters. In charged conversations, remember: The goal… read on > read on >
Yoga Helps Women Deal With the Mental Stress of Cancer
A cancer diagnosis can bring overwhelming stress and depression to women, but new research suggests yoga can help ease that emotional toll. “A wellness intervention that integrates yoga and psychological tools may strengthen the connections among the mind, body and spirit, leading to a better and more meaningful quality of life,” said study senior author Deidre Pereira. She’s an associate professor of clinical and health psychology at the University of Florida (UF) in Gainesville. The new research involved 51 women who’d been diagnosed with some form of gynecological, gastrointestinal or thoracic cancer. According to a university news release, they “enrolled in a 10-week, in-person, group intervention that used breathing and relaxation techniques, mindfulness meditation, psychotherapy skills and gentle yoga aimed at improving physical and mental quality of life.” Based on answers to detailed questionnaires, Pereira’s team found women reporting a lowering of their symptoms of anxiety and depression after completing the program. When it came to the physical symptoms of depression, the program was especially helpful to women of color, the researchers noted. “Quality of life during and beyond cancer treatment is a critical component of whole-person cancer care,” explained study co-lead author Elizabeth Kacel, a recent graduate of the clinical psychology doctoral program at UF. It’s the program’s use of yoga/meditation alongside psychotherapeutic training that really seemed to help, she added. “The combination of both… read on > read on >
Reaching Age at Which a Parent Died by Suicide Raises Risk in Adult Child
When people whose parents died by suicide reach that same age, their own risk often spikes, Danish researchers warn. Reporting in the journal Suicide and Life-Threatening Behaviors, the researchers looked at data on more than 470,000 Danes whose parents died between 1980 and 2016. Of those, 17,806 individuals had parents who died by suicide. The study looked at the risk of self-harm and suicide during the year before and after individuals reached the age of their deceased parent — typically about 24 years later. Compared to the 15 years before or after, they were at roughly twice the risk of self-harm or suicide when they reached the corresponding age. Individuals whose parent died of other causes had no increased risk during the corresponding time. “Our findings support the practice of asking suicide-bereaved individuals about age at parental suicide, identifying this as an anticipated period of increased risk,” wrote a team led by Yanakan Logeswaran, of the University College of London. “This is also an opportunity to reinforce that suicide is not inevitable after the suicide of a parent, with an absolute risk … estimated at less than 1%,” they added in a American Psychiatric Association news release. More information If you have suicidal thoughts, free, confidential help is available 24/7. Call or text to 988 to reach the Suicide & Crisis Lifeline. Or chat with… read on > read on >
Could a Common Thyroid Medicine Weaken Bones?
New research suggests that a thyroid medication often prescribed to older Americans may be linked to a common problem in old age — bone loss. Levothyroxine is a synthetic hormone often prescribed to treat hypothyroidism. People with the condition don’t make enough thyroxine on their own, which can cause weight gain, fatigue, hair loss and eventually lead to serious, even deadly, complications. An estimated 23 million Americans take levothyroxine daily. Some take it for so long that it’s no longer clear why it was prescribed to begin with or even if it is still needed, researchers said. “Data indicates that a significant proportion of thyroid hormone prescriptions may be given to older adults without hypothyroidism,” said study leader Dr. Elena Ghotbi, a postdoctoral research fellow at Johns Hopkins University School of Medicine in Baltimore. A normal range for thyroid-stimulating hormone (TSH) in the blood is between 0.4 to 5.0 microunits per milliliter. Excess TSH has been tied to increased risk of broken bones. For this study, Ghotbi’s team wanted to learn whether using levothyroxine and having hormone levels on the high end of that range might cause more bone loss over time in older adults with normal thyroid function. They drew on data from 445 participants in a Baltimore-based study of older adults with normal thyroid levels. Participants included 49 women and 32 men taking… read on > read on >
For Some, ‘Tis the Season for Loneliness. Experts Offer Tips to Stay Connected
For many, the holidays are a time when you connect with others and share time with loved ones. But for some, the holidays are a painful exercise in loneliness. While a Northwestern Medicine study published last spring found loneliness is more prevalent in both younger and older adults, those feelings intensify around the holidays, said Eileen Graham, who co-authored that study. And those feelings are most pronounced for the oldest. “What was striking was how consistent the uptick in loneliness is in older adulthood,” Graham noted when the study was published. “There’s a wealth of evidence that loneliness is related to poorer health, so we wanted to better understand who is lonely and why people are becoming lonelier as they age out of midlife so we can hopefully start finding ways to mitigate it.” One way to ease loneliness for these folks is to invite them into your home. “Young adults who are living in unfamiliar cities and setting up new social networks will often find ways to celebrate with Friendsgivings because they might not be coming home for the holidays,” said Graham, an associate professor of medical social sciences at Northwestern University Feinberg School of Medicine. “Others include older adults who have lost friends or spouses and, finally, people who have fewer resources.” How else can folks deal with those heightened feelings of isolation during the… read on > read on >
Taking a GLP-1 Medication? Here’s Tips to Holiday Eating
So, you have managed to shed 30 pounds with the help of one of the new blockbuster GLP-1 drugs, but as the holidays near you worry about how to handle gatherings where decadent food will be served in abundance. Luckily, one expert from Baylor College of Medicine has tips on how to enjoy holiday fare while on these medications, without overdoing it. GLP-1 medications, which include Ozempic, Wegovy, Mounjaro and Zepbound, curb appetite and slow the digestion of food, so consuming large portions on these drugs can make you sick and worsens the nausea that is associated with them. What to do? Stick with small portions. “You lose the benefit of weight loss if you do not watch your diet,” said Dr. Mandeep Bajaj, a professor of medicine – endocrinology, diabetes and metabolism at Baylor. “In addition, if you are taking GLP-1 receptor agonists for treatment of diabetes, overindulging will worsen your diabetes control, and you will lose the benefit of the therapy.” Those who take GLP-1s should not stop taking them during the holidays, to avoid regaining the weight already lost. Tips to stay on track with your medication this holiday season include: Consume whole foods and a nutrient-dense diet made up of minimally processed food: eat vegetables, lean proteins, fiber and whole grains Eat smaller portions: more than half your plate should consist of lean meat… read on > read on >
’10 Americas:’ Health Disparities Mean Life Expectancy Varies Across U.S.
How long Americans can expect to live varies dramatically — and the gap continues to widen. A new report says health inequalities have, in essence, created 10 Americas. These mutually exclusive populations are divided along familiar fault lines, including race, ethnicity, income and address. While life expectancy rose in nine of 10 Americas between 2000 and 2010, only six saw gains between 2010 and 2019, according to the report. And it plummeted in all 10 in 2021, the first year of the pandemic. In 2021, Asian Americans had the longest life expectancy at birth — 84 years. That’s two decades more than the group with the lowest life expectancy: American Indians and Alaska Natives living in the West, who were expected to live 63.6 years. “The extent and magnitude of health disparities in American society are truly alarming in a country with the wealth and resources of the USA,” said Christopher Murray, director of the University of Washington’s Institute for Health Metrics and Evaluation. “These disparities reflect the unequal and unjust distribution of resources and opportunities that have profound consequences on well-being and longevity, especially in marginalized populations.” Murray is senior author of the report, which was published Nov. 21 in The Lancet, a British health journal. It builds on an earlier study that identified “Eight Americas” based on race, geography, ethnicity, per capital income… read on > read on >