All Sauce from Weekly Gravy:

Early and gradual exposure to peanuts under medical supervision curbed infants’ allergies, according to a new study. While researchers had seen that peanut oral immunotherapy was well tolerated by toddlers, this research focused on an even younger age group. “We’ve seen how peanut oral immunotherapy is well-tolerated in toddlers, but there is limited real-world evidence available to demonstrate the benefits in babies,” said Dr. Sandra Hong, director of the Food Allergy Center of Excellence at the Cleveland Clinic. “We leveraged data from infants in our program to better understand the safety and efficacy of this treatment in children 12 months and younger.” The clinic’s Food Allergy Center of Excellence offers oral immunotherapy for babies, toddlers and young children who are allergic to peanuts. There, children under age 4 eat tiny amounts of peanuts in a step-by-step, controlled process. This study enrolled 22 infants between 7 and 11 months old. With an allergist and parent, the babies started on a daily dose of 18 milligrams of peanut protein in the form of peanut butter or peanut powder. That’s roughly twice the weight of a grain of table salt. Over six months, they were slowly given larger servings to consume until they reached a maintenance dose of 500 milligrams, the equivalent of two peanut kernels. Each of the 22 babies reached this milestone. More than half experienced…  read on >  read on >

Whether you got a tattoo on a whim or after much thought, that ink on your body is fairly permanent. Tattoo removal is possible, but it comes with risks, according to the U.S. Food and Drug Administration, which regulates tattoo ink and pigment, as well as the laser devices used to remove them. State and local authorities typically oversee tattooing practices. The FDA has cleared several types of lasers for tattoo lightening or removal. They are to be used by or under the supervision of a health care professional. The process requires using the correct type of laser, understanding how tissue will react and knowing how to treat the area after the procedure. One challenge with removal is that tattoos are more than skin deep. The needle injects ink into the skin, penetrating the epidermis, or outer layer. And it also deposits a drop of ink into the dermis, the layer underneath. The cells of the dermis are more stable than those of the epidermis, which, the FDA said, means the ink will mostly stay in place for a person’s lifetime. Lasering is the most common method for removing or lightening tattoos, according to the FDA. Laser light energy shatters the tattoo ink into small particles, and the immune system clears these particles over time. Different types of lasers may be used depending on the…  read on >  read on >

The U.S. Food and Drug Administration on Friday approved a new pill, called zuranolone, that may quickly ease severe postpartum depression and help millions of women regain their emotional equilibrium following childbirth. Taken as a pill once a day for two weeks, zuranolone (Zurzuvae) showed “rapid, significant and sustained” reductions in depressive symptoms when compared to a placebo, according to a recent study of nearly 200 women, the FDA said. These improvements occurred in as few as three days and were still evident 28 and 45 days later. That’s compared to the many weeks it typically takes for standard antidepressants to start taking full effect. “Postpartum depression is a serious and potentially life-threatening condition in which women experience sadness, guilt, worthlessness — even, in severe cases, thoughts of harming themselves or their child. And, because postpartum depression can disrupt the maternal-infant bond, it can also have consequences for the child’s physical and emotional development,” Dr. Tiffany Farchione, director of the Division of Psychiatry in the FDA’s Center for Drug Evaluation and Research, said in an agency statement. “Having access to an oral medication will be a beneficial option for many of these women coping with extreme, and sometimes life-threatening, feelings.” As many as 1 in 8 women in the United States develops depression just before or after giving birth. “Women report severe sadness or loss…  read on >  read on >

FRIDAY, Aug, 4, 2023Steroids are often unnecessarily prescribed to pregnant women thought to be at risk of preterm birth, a new evidence review contends. As a result, millions of babies are needlessly exposed to long-term health problems associated with steroid use in gestation, such as increased risk of infection and delayed brain development, researchers say. Steroids can’t prevent preterm birth, but they can accelerate the maturation of developing organs and give preemies a fighting chance for survival, said lead researcher Dr. Sarah McDonald, a professor of obstetrics at McMaster University in Ontario, Canada. However, two out of every five infants given steroids in the womb wound up being born full-term anyway, according to pooled data on 1.6 million babies from 17 previous studies. Compared to other at-term babies not given steroids, those infants had an increased risk of requiring neonatal intensive care, being put on a respirator, and developing long-term brain development and behavioral disorders, according to the review published Aug. 2 in the BMJ. “I like to say that steroids are powerful medications, and with great power comes great responsibility,” McDonald said. “We need to try to tailor the administration of these medications to pregnancies that are really at risk of preterm birth so we’re not exposing babies who go on and be born at term to these powerful medications.” In the same issue…  read on >  read on >

Workers may sense it intuitively but their mouse clicks prove it: Friday afternoon is the least productive time of the work week. It’s also when workers make the most typos. A Texas A&M University team studied this using the computer usage metrics of 789 in-office employees at a large energy company over two years. “Most studies of worker productivity use employee self-reports, supervisory evaluations or wearable technology, but these can be subjective and invasive,” said co-author Mark Benden, head of the university’s Department of Environmental and Occupational Health. “Instead, we used computer usage metrics — things like typing speed, typing errors and mouse activity — to get objective, noninvasive data on computer work patterns,” he said in a university news release. The researchers compared computer use across different days of the week and times of the day to see what kinds of patterns emerged. “We found that computer use increased during the week, then dropped significantly on Fridays,” said study leader Taehyun Roh, an assistant professor of epidemiology and biostatistics. “People typed more words and had more mouse movement, mouse clicks and scrolls every day from Monday through Thursday, then less of this activity on Friday.” Computer use fell off every afternoon — especially on Fridays — the data revealed. “Employees were less active in the afternoons and made more typos in the afternoons —…  read on >  read on >

Ever feel like your job is pointless? A big part of the population feels just that way — that the jobs they do matter little to society. And a Swiss study that delved into what’s been dubbed the “bullshit jobs theory” found that feeling was especially likely for folks in financial, sales and management jobs. About 19% of employees found their work rarely or never gave them “a feeling of making a positive impact on community and society” and “the feeling of doing useful work,” the study found. That finding is in line with the “bullshit jobs theory” espoused by the late American anthropologist David Graeber, who maintained that some jobs are socially useless. “Employees’ assessment of whether their work is perceived as socially useless is a very complex issue that needs to be approached from different angles,” study leader Simon Walo, a sociologist at the University of Zurich, said in a university news release. “It depends on various factors that do not necessarily have anything to do with the actual usefulness of work as claimed by Graeber. For example, people may also view their work as socially useless because unfavorable working conditions make it seem pointless,” Walo explained. In addition to Graeber’s theory, other researchers have suggested that people consider their jobs useless not because of the importance of their work but because it…  read on >  read on >

When studying which personality types were more likely to resist getting vaccines, researchers got a surprise. It was the extroverts who were more vaccine resistant. Compared to other personality styles, extroverts were 18% more likely to refuse the COVID-19 vaccine, the new study finds. “We expected that people who were especially high in extroversion would be more likely to get the vaccine,” said lead author Melissa Baker, an assistant professor at the University of Texas at El Paso. “We figured those people would want to get back out in the world and socialize, right? It’s actually the opposite,” she added in a university news release. The researchers hope their findings may help with future public health messaging and vaccination campaigns. “We wanted to look at vaccine hesitancy a different way,” Baker said. “Of course, politics can help explain some of it, but there are personal differences between people, too — and that led us to this personality aspect.” Joining with a researcher from the University of Toronto, the study team used surveys of more than 40,000 Canadian adults, taken between November 2020 and July 2021. Questions evaluated each participant’s personality, based on a model known as “big five.” This gauges someone’s openness, conscientiousness, extraversion, agreeableness and emotional stability. Other questions were focused on vaccination, including, “When a COVID-19 vaccine becomes available, will you be vaccinated?”…  read on >  read on >

The trauma and unhappy family dynamics of childhood may follow kids into old age, affecting both their mind and body, according to new research. “We looked at self-reported disability, as well as objectively measured physical and cognitive impairment, and learned that early-life stressful experiences can have ramifications all the way into older age,” said senior author Dr. Alison Huang, a University of California, San Francisco professor of medicine. “This can mean a higher likelihood of difficulty walking, or carrying out activities of daily living, or problems with memory when people are in their 60s, 70s, 80s or older,” she said in a university news release. Exposure to physical violence or abuse, severe illness, family financial stress or separation from parents are considered major childhood stressors. The study found that those who experienced violence in childhood were 40% more likely to have mobility impairment and 80% more likely to have difficulty with daily activities. Those who came from unhappy families were 40% more likely to have mild cognitive impairment. According to the U.S. Centers for Disease Control and Prevention, almost 60% of adults in the United States have experienced one or more types of adverse childhood experiences. These can undermine a child’s sense of safety or stability, and are tied to later heart disease, diabetes, autoimmune disease and depression. California was the first state to mandate…  read on >  read on >

A Louisiana woman is suing the makers of two type 2 diabetes drugs used off-label for obesity, saying they failed to adequately warn about the risk of severe stomach problems. The lawsuit seeks “very significant” but unspecified compensation from the makers of both Ozempic and Mounjaro, said attorney Paul Pennock of the Orlando, Fla.-based firm Morgan & Morgan. Pennock filed the lawsuit Wednesday on behalf of Jaclyn Bjorklund, 44, NBC News reported. The lawsuit against Novo Nordisk and Eli Lilly claims Bjorklund was “severely injured” after taking the two diabetes drugs, which are part of a new class of medication called GLP-1 agonists. Pennock said she is suffering “persistent” vomiting and severe gastroparesis, also known as stomach paralysis. Gastroparesis slows or stops food from moving out of the stomach and into the small intestines. It can be caused by underlying medical issues, including diabetes, according to the American College of Gastroenterology. Infections and some medication can also cause it. The GLP-1 agonists slow food’s movement and have been found to cause some GI issues in clinical trials. Those are listed as side effects on the drug labels. Both Ozempic and Mounjaro have the phrase “delays gastric emptying” on their prescribing information, though they don’t specifically use the word “gastroparesis,” NBC News reported. A U.S. Food and Drug Administration spokeswoman said it was unclear whether the…  read on >  read on >

Yoga is known for its benefits to both the mind and body. And a gentle form of yoga may be an ideal early intervention technique for older women at risk of Alzheimer’s disease, new research suggests. In a small study involving kundalini yoga, participants reported that its stress-relieving effects translated to more efficient memory. “Women tend to practice yoga more readily than men. And I’ve done other studies previously in people, older adults with mild cognitive [mental] impairment and in caregivers with similar interventions,” said Dr. Helen Lavretsky, the lead psychiatrist on the study. “We are focusing now on women who are not as impaired as in my previous study, but still at risk for cognitive decline. And the idea is to get to the level where doing yoga would prevent future cognitive decline and development of Alzheimer’s disease,” said Lavretsky, a professor-in-residence at the University of California, Los Angeles. Kundalini yoga involves chanting, singing, breathing exercises, meditation and gentle poses with the aim of increasing awareness in the mind and body. Previous scientific research has found that yoga can help regulate blood pressure and increase cardiorespiratory fitness, as well as benefit the hippocampus, or the region in the brain that is associated with memory. In this study, scientists examined the effects of kundalini yoga versus memory enhancement training (MET) on the hippocampus in 22…  read on >  read on >