All Sauce from Weekly Gravy:

The trauma and unhappy family dynamics of childhood may follow kids into old age, affecting both their mind and body, according to new research. “We looked at self-reported disability, as well as objectively measured physical and cognitive impairment, and learned that early-life stressful experiences can have ramifications all the way into older age,” said senior author Dr. Alison Huang, a University of California, San Francisco professor of medicine. “This can mean a higher likelihood of difficulty walking, or carrying out activities of daily living, or problems with memory when people are in their 60s, 70s, 80s or older,” she said in a university news release. Exposure to physical violence or abuse, severe illness, family financial stress or separation from parents are considered major childhood stressors. The study found that those who experienced violence in childhood were 40% more likely to have mobility impairment and 80% more likely to have difficulty with daily activities. Those who came from unhappy families were 40% more likely to have mild cognitive impairment. According to the U.S. Centers for Disease Control and Prevention, almost 60% of adults in the United States have experienced one or more types of adverse childhood experiences. These can undermine a child’s sense of safety or stability, and are tied to later heart disease, diabetes, autoimmune disease and depression. California was the first state to mandate…  read on >  read on >

A Louisiana woman is suing the makers of two type 2 diabetes drugs used off-label for obesity, saying they failed to adequately warn about the risk of severe stomach problems. The lawsuit seeks “very significant” but unspecified compensation from the makers of both Ozempic and Mounjaro, said attorney Paul Pennock of the Orlando, Fla.-based firm Morgan & Morgan. Pennock filed the lawsuit Wednesday on behalf of Jaclyn Bjorklund, 44, NBC News reported. The lawsuit against Novo Nordisk and Eli Lilly claims Bjorklund was “severely injured” after taking the two diabetes drugs, which are part of a new class of medication called GLP-1 agonists. Pennock said she is suffering “persistent” vomiting and severe gastroparesis, also known as stomach paralysis. Gastroparesis slows or stops food from moving out of the stomach and into the small intestines. It can be caused by underlying medical issues, including diabetes, according to the American College of Gastroenterology. Infections and some medication can also cause it. The GLP-1 agonists slow food’s movement and have been found to cause some GI issues in clinical trials. Those are listed as side effects on the drug labels. Both Ozempic and Mounjaro have the phrase “delays gastric emptying” on their prescribing information, though they don’t specifically use the word “gastroparesis,” NBC News reported. A U.S. Food and Drug Administration spokeswoman said it was unclear whether the…  read on >  read on >

Yoga is known for its benefits to both the mind and body. And a gentle form of yoga may be an ideal early intervention technique for older women at risk of Alzheimer’s disease, new research suggests. In a small study involving kundalini yoga, participants reported that its stress-relieving effects translated to more efficient memory. “Women tend to practice yoga more readily than men. And I’ve done other studies previously in people, older adults with mild cognitive [mental] impairment and in caregivers with similar interventions,” said Dr. Helen Lavretsky, the lead psychiatrist on the study. “We are focusing now on women who are not as impaired as in my previous study, but still at risk for cognitive decline. And the idea is to get to the level where doing yoga would prevent future cognitive decline and development of Alzheimer’s disease,” said Lavretsky, a professor-in-residence at the University of California, Los Angeles. Kundalini yoga involves chanting, singing, breathing exercises, meditation and gentle poses with the aim of increasing awareness in the mind and body. Previous scientific research has found that yoga can help regulate blood pressure and increase cardiorespiratory fitness, as well as benefit the hippocampus, or the region in the brain that is associated with memory. In this study, scientists examined the effects of kundalini yoga versus memory enhancement training (MET) on the hippocampus in 22…  read on >  read on >

Golfing may be a great way to get outdoors and enjoy the pleasures of a classic summer pastime. But a new study warns that walking the greens for hours on end without adequate sun protection may notably increase the risk for skin cancer. Researchers in Australia found that more than one-quarter of golfers in that country have been diagnosed with skin cancer at some point, making Aussie players 2.4 times more likely to get the disease than their non-golfing peers. “Our previous research, and that of others worldwide, has demonstrated the positive impact of golf on people’s health, including physical, mental and cognitive well-being,” said study lead author Brad Stenner. At the same time, “Australia is well known for its high skin cancer rates, and frequency and intensity of sun exposure,” said Stenner, a lecturer in health and human performance at the University of South Australia in Adelaide. However, “the cumulative effects of sun exposure do increase the risks of skin cancer, regardless of where you live,” he added. Knowing this, golfers should more actively strive to protect themselves, Stenner and other experts said. In the new research, just 7% of those in the general public reported ever having a skin cancer diagnosis versus 27% of the golfers. This suggests golfers face a nearly 250% greater risk of developing skin cancer than non-players, the study…  read on >  read on >

More girls started puberty before age 8 during the COVID-19 pandemic, a phenomenon called precocious puberty, researchers say. The reasons include potential risk factors such as increased screen time and less exercise, according to a new study, published online Aug. 3 in the Journal of the Endocrine Society. In precocious puberty, children’s bodies begin changing into adult bodies too soon. These changes normally begin between age 8 and 14. The number of girls referred to pediatric endocrinologists for precocious puberty rose substantially over the past two years, researchers found. COVID-19 has also been linked to endocrine diseases, including obesity, which can contribute to early puberty in girls. “Our study confirms the rise in precocious puberty diagnoses during COVID-19 and identifies contributing factors such as poor eating and exercise habits, too much screen time and impaired sleep,” said study author Dr. Mohamad Maghnie, of the University of Genoa and the Giannina Gaslini Institute in Italy. “We found an increase in weight gain among girls diagnosed with precocious puberty during the pandemic, and rapid increase in body weight is associated with advanced pubertal development,” he said in a journal news release. The researchers studied data on rates of precocious puberty from before and after the pandemic in 133 girls in Italy. They also considered the possible relationship between COVID-19 and pandemic-related lifestyle changes. They found 72 cases…  read on >  read on >

J.D. Butler was planning a future with his girlfriend at his favorite New York City restaurant when that future came to a sudden, crushing halt. “They were planning on when she was moving in and arranging floor plans on the table, with where the furniture was going to go,” said his mother, Karen Butler, a lifelong New York resident. “And he had a grand mal seizure, and then his heart stopped.” A subsequent autopsy revealed that J.D.’s fatal seizure was brought on by mitragynine toxicity, caused by long-term ingestion of the widely used herbal supplement kratom, Butler said. “She said there was evidence in his organ tissue that it had been in his body consistently for a while,” Butler said. “It’s one of those drugs to which you develop a tolerance, so you have to keep taking more and more and more.” Kratom is coming under fire in the United States, targeted by a series of lawsuits following wrongful deaths associated with its use. A Florida jury awarded $11 million last week to the family of a woman who died after taking kratom, in a lawsuit against the company that sold her the supplement, according to NBC News. The woman, a 39-year-old mother of four, collapsed in her kitchen while making breakfast for her family in June 2021. A coroner said Krystal Talavera died from…  read on >  read on >

So, your high schooler has been complaining of headaches. Should you worry? Maybe, claims new research that finds bullying and suicidal thoughts are both linked to more frequent headaches in teens. “Headaches are a common problem for teenagers, but our study looked beyond the biological factors to also consider the psychological and social factors that are associated with headaches,” said study author Dr. Serena Orr, of the University of Calgary, in Canada. “Our findings suggest that bullying and attempting or considering suicide may be linked to frequent headaches in teenagers, independent of mood and anxiety disorders.” This isn’t proof that bullying causes headaches, but shows an association between the two. A study limitation is that headaches were self-reported. The research included more than 2.2 million teens who were an average age of 14. About 0.5% of all the participants self-reported being gender-diverse, including transgender or nonbinary. The participants answered questions about their headaches, including if they had them in the past six months and how often. The teens also answered questions regarding mental health, including whether they had diagnosed mood or anxiety disorders or both; about bullying in the past year and about suicidal thoughts and attempts. About 11% of participants reported having frequent, recurring headaches, defined as headaches occurring more than once a week. About 25% of the participants reported being victims of frequent…  read on >  read on >

While demand for prescription stimulants is surging, a shortage of the drugs persists, so federal officials have stepped in and asked drug companies to ramp up production of the medications. Officials from both the U.S. Food and Drug Administration and the U.S. Drug Enforcement Administration (DEA) made the joint request. “The FDA and DEA do not manufacture drugs and cannot require a pharmaceutical company to make a drug, make more of a drug or change the distribution of a drug,” FDA Commissioner Dr. Robert Califf and Drug Enforcement Administration leader Anne Milgram wrote in a letter issued Tuesday. “That said, we are working closely with numerous manufacturers, agencies and others in the supply chain to understand, prevent and reduce the impact of these shortages.” The agencies are also asking prescribers to carefully monitor their prescribing practices. “The lack of availability of certain medications in recent months has been understandably frustrating for patients and their families,” Califf and Milgram wrote in their letter. Reasons for the shortage include manufacturing delays by one drugmaker last fall. Meanwhile, demand for prescription stimulants for adults surged during the pandemic, according to a U.S. Centers for Disease Control and Prevention report. The FDA first announced a shortage of Adderall last October; that medication is commonly used for those with attention deficit hyperactivity disorder (ADHD). The DEA limits the amount of…  read on >  read on >

Millions of American smokers suffer from a potentially serious lung disease that’s not technically chronic obstructive pulmonary disease (COPD), a new study finds. They would benefit from a clear diagnosis, though, and the new findings demonstrate a major gap in care for people with a history of tobacco use, the researchers said. Among folks who smoked at least one pack of cigarettes a day for 20 or more years, half had persistently high respiratory symptoms, including shortness of breath, daily cough and phlegm, and decreased ability to exercise, although they did well in the breathing tests used to spot COPD. The researchers call the condition “tobacco exposure preserved spirometry” (TEPS). “We first described TEPS in 2016. What we’re showing here is the long-term follow up, and it’s not like an early COPD. It stays persistent the way it is over time,” said lead researcher Dr. Prescott Woodruff, division chief of pulmonology at the University of California, San Francisco. Right now, there is no treatment for TEPS, he said. “It does improve in many people when they stop smoking, but not everyone,” Woodruff said. Woodruff’s team tried treating patients with bronchodilators used to treat COPD. The drugs improved lung function but not the symptoms, he said. “TEPS may be due to abnormal mucus production, so therapies that could control mucus might be the best therapies,” Woodruff…  read on >  read on >

All eyes are on the U.S. Food and Drug Administration this week as the agency weighs approval of a new pill that may quickly treat and ease severe postpartum depression. Approval of the drug could help millions of women regain their emotional equilibrium following childbirth. The FDA’s decision is expected by Friday. Taken as a pill once a day for two weeks, zuranolone showed “rapid, significant and sustained” reductions in depressive symptoms when compared to a placebo, or dummy pill, according to a recent study of nearly 200 women. These improvements occurred in as few as three days and were still evident 28 and 45 days later, said study author Dr. Kristina Deligiannidis. She is a professor at the Institute of Behavioral Science at the Feinstein Institutes for Medical Research in Manhasset, N.Y. As many as 1 in 8 women in the United States develops depression immediately before or after giving birth. “Women report severe sadness or loss of interest in pleasurable activities and relationships, have significant guilt, often about not being a good enough mother or partner, low energy, poor concentration and indecisiveness, loss of appetite and irritability,” Deligiannidis said. Many also say they feel overwhelmed and are anxious, especially over the baby’s well-being, she added. Some women may start to believe that their family would be better off if they were dead, she…  read on >  read on >