All Sauce from Weekly Gravy:

A new diagnosis of Alzheimer’s or other dementia often spurs a person to move from their home, new research shows. “One possible explanation is that individuals with dementia and their caregivers may choose to move closer to family or informal caregivers, either with independent housing arrangements or entering formal long-term care services,” wrote a team led by Momotazur Rahman, an associate professor of health services, policy and practice at Brown University in Providence, R.I. The study was published Oct. 14 in the journal JAMA Network Open. The researchers used Medicare data on the residential histories of over 1.6 million Medicare beneficiaries. All had received a diagnosis of either dementia, heart attack, chronic obstructive pulmonary disease (COPD) or colon cancer in 2016.  Each person’s domicile (including nursing homes) was tracked over the eight years before and after the 2016 diagnosis — 2012 through 2020. In the four years before a dementia diagnosis, there was no difference observed in where people lived or whether they relocated, the study found. However, within the four years of a dementia diagnosis, 22% of people moved to a different U.S. county, Rahman’s group found. That’s a 40% jump in relocations compared to folks who’d been diagnosed with other conditions, such as heart attack or COPD. People with a dementia diagnosis were also more likely to move to another state, the study…  read on >  read on >

Doctors might be overprescribing sedatives to stroke survivors, a new study warns. About 5% of people are prescribed a benzodiazepine following a stroke, to help calm anxiety and improve sleep, researchers found. Benzodiazepine meds include Valium, Ativan and Xanax. But these prescriptions often are for pills that last longer than a week, which could hamper a person’s recovery and increase their risk of addiction. “We found a pattern of potential oversupply with these initial benzodiazepine prescriptions, which would be enough for patients to become long-term users or possibly addicted,” said researcher Julianne Brooks, a data analytics manager at Massachusetts General Brigham in Boston. “The benzodiazepine prescriptions given under these circumstances may lead to dependence.” For the study, researchers analyzed a decade’s worth of Medicare claims data on first-time prescriptions for benzodiazepines among more than 120,000 stroke victims aged 65 and older. “For this older age group, guidelines recommend that benzodiazepine prescriptions should be avoided if possible,” Brooks said. These sedatives increase the risk of falls, broken bones, memory problems, confusion and other harmful effects, the researchers said. “However, there may be cases where benzodiazepines are prescribed to be used as needed,” Brooks noted. “For example, to treat breakthrough anxiety, a provider may prescribe a few pills and counsel the patient that the medication should only be used as needed.” Researchers found that about 5% of…  read on >  read on >

Alzheimer’s disease might damage the brain in two distinct phases, a new study suggests. An early phase that occurs slowly and silently appears to lay the groundwork for a second, more widely destructive phase of Alzheimer’s, according to sophisticated brain scans. “The results fundamentally alter scientists’ understanding of how Alzheimer’s harms the brain and will guide the development of new treatments for this devastating disorder,” said Dr. Richard Hodes, director of the National Institute on Aging. Previous studies have suggested that the damage caused by Alzheimer’s occurs in several stages, characterized by increasing levels of neuron death, inflammation and accumulation of toxic proteins in the brain. But these results indicate there really are just two phases of Alzheimer’s, with most of the traditional symptoms and brain damage happening rapidly during the second phase, researchers said. Brain scans of 84 people suggest that the first phase occurs prior to any memory problems that might develop. During this phase, damage occurs to a type of brain cell called an inhibitory neuron that might trigger the neural problems that underlie Alzheimer’s, researchers said. Inhibitory neurons send calming signals to other cells, researchers said. Losing these cells might strip the brain of a key level of protection. The first phase also is marked by a slow accumulation of toxic protein plaques, activation of the brain’s immune system, and damage…  read on >  read on >

A young Israeli researcher who lost a sibling in the Oct. 7, 2023 Hamas attack on Israeli civilians said the tragedy has spurred her to study the unique aspects of grief at the sudden loss of a brother or sister. The research by Master of Arts student Masada Buchris, of Hebrew University in Jerusalem, hasn’t yet been published in a peer-reviewed journal and will become part of her thesis. But it’s already showing that grief over lost siblings differs from grief felt by the loss of a parent, partner or child. “This research is deeply personal for me,” Buchris said in a university news release. “Losing my sibling on October 7th was a life-altering event, and it became clear that many bereaved siblings face ‘unrecognized grief.’ This study is the first step towards understanding the profound consequences of such a loss and ensuring that siblings receive the support they need.” Buchris’ work focused on 444 people who lost a sibling in the Oct. 7 attacks, which killed over 1,200 people, according to the U.S. Department of State. The bereaved siblings averaged about 32 years of age, and just over two-thirds interviewed were women. Buchris said she used various standard psychological measurements to gauge each person’s “emotional distress, negative thoughts and coping mechanisms.” Her study so far has discovered that grief at the loss of a…  read on >  read on >

Obesity is a more powerful driver of breast cancer than previously thought, a new study suggests. About 40% of hormone-positive breast cancers in postmenopausal women might be linked to excess body fat, researchers reported Oct. 15 in the Journal of Epidemiology & Community Health. That’s significantly more than previous estimates that linked excess weight to 1 in 10 breast cancer cases, based on measures of women’s body-mass index (BMI), researchers said. The real-world impact of obesity on breast cancer risk likely has been underestimated because BMI isn’t a very accurate measure of body fat, the researchers argued. “The findings of this study highlight the importance of considering more accurate measures of body fat than BMI to estimate the cancer burden attributable to obesity in postmenopausal breast cancer,” concluded the research team led by Veronica Davila-Batista, an associate professor of epidemiology with the University of Las Palmas de Gran Canaria in Spain. For this study, researchers compared BMI with a different measure of body fat called the CUN-BAE, an equation which accounts for gender and age in BMI measurements. The two measures were used to weigh 1,022 older Spanish women with breast cancer and another 1,143 matched women who didn’t have cancer. About 23% of breast cancer cases were linked to excess body weight as measured by BMI, researchers found. However, about 38% of breast cancers…  read on >  read on >

Folks with peanut allergies don’t have to worry that someone might be munching on the nuts during an airline flight, researchers report. It turns out there’s no evidence to the commonly held belief that nut allergens can be spread through aircraft ventilation systems, a new review concluded. “In fact, food-induced allergic reactions are around 10–100 times less common during flights than ’on the ground’, perhaps because of the multiple precautions food-allergic passengers take when flying,” wrote the research team led by Paul Turner, a clinical professor of allergy and immunology with the Imperial College London’s National Heart & Lung Institute. For the review, published Oct. 15 in the Archives of Disease in Childhood, researchers compiled all published evidence on the subject dating back to 1980. Overall, any allergic reactions to food caused by airborne particles are rare, researchers found. Notable exceptions include vapors from fish or seafood and exposure to wheat flour at work. Peanut allergens can be detected at very low levels in the air while shelling nuts, researchers said, but the dust settles quickly and can only be detected close to the nuts. That means very little peanut dust circulates in the air. What’s more, air is completely exchanged every three to four minutes during a flight by the cabin’s ventilation system. Half of the cabin’s air intake is recirculated air that has…  read on >  read on >

Pharmacists may continue making compounded versions of the weight-loss medication tirzepatide while the U.S. Food and Drug Administration revisits its Oct. 2 decision to remove the medicine from a national drug shortage list. What prompted the FDA to reconsider its decision? On Oct. 7, a compounding trade group filed a lawsuit challenging the agency’s action, saying there was still a shortage of the wildly popular drug. On Friday, the FDA responded in a court filing that compounding pharmacies could continue making the drug while the agency re-evaluates its finding, NBC News reported. Shortages of tirzepatide, sold as a diabetes drug (Mounjaro) and a weight-loss medication (Zepbound), have fueled demand for compounding pharmacies to make their own versions of the medicine, which patients say are cheaper and easier to get.  During FDA-declared drug shortages, compounding pharmacies can make versions that are copies of the brand-name drugs in shortage. But the agency’s Oct. 2 announcement said pharmacies that produce large batches of medications would no longer be able to accept new orders of tirzepatide and had 60 days to fill their existing orders. The agency’s Friday filing said its latest move was “effectively the relief that Plaintiffs sought in their motion.” In the filing, the agency said it wouldn’t “take action” against the plaintiffs and their members making compounded versions of the drugs as it re-evaluates its decision, NBC News reported. …  read on >  read on >

People sense millisecond shifts in odor as quickly as they might spot a change in color, new research shows. The study discounts the notion that smell is a “slower” sense than sight or hearing, scientists say. “A sniff of odors is not a long exposure shot of the chemical environment that averages out” over time, explained study lead author Dr. Zhou Wen, at the Institute of Psychology of the Chinese Academy of Sciences. Instead, smell can spot fluctuations in odors with a “sensitivity on par with that for color perception” in vision, she said in an academy news release. Zhou’s team published its findings Oct. 14 in the journal Nature Human Behaviour. Human’s sense of smell is nowhere near that of many animals, such as dogs. But it may not be as sluggish as most people think, the new study found. In their experiments, the Chinese team constructed a special sniff-triggered device that organized the emissions of odors with a precision of 18 milliseconds. Using the device, they had it produce two odors one after the other, separated by milliseconds, switching which odor came first. They then had 229 people sniff the odors to see if they could sense any differences. According to the academy news release, “participants could tell the difference when the delay between the compounds was just 60 milliseconds — about a…  read on >  read on >

It’s natural for a parent to bundle an injured child into a car and rush their kid to the emergency room. But that decision could actually delay their child’s emergency care, a new study shows. Severely injured children brought to an ER by their parents aren’t treated as quickly as those who arrive via ambulance, the researchers discovered. On average, a child brought to an emergency room by a parent will wait nearly an hour before they’re seen by an ER doctor, researchers found. That’s because paramedics call ahead to alert an ER prior to arrival, explained researcher Dr. Robert Hirst, an emergency medicine registrar with the Bristol Royal Hospital for Children in the United Kingdom. “This leads to early trauma team activation, resulting in specialist services and resources being ready and prepared to see these patients as soon as they arrive,” Hirst said. “This has been shown to be associated with better outcomes for children with significant injuries.” Parents bringing a badly injured child in themselves “can lead to delays in the appropriate level of care being provided,” Hirst added. For the study, researchers analyzed data on 24 children brought to the Bristol Royal Hospital by their parents following a severe injury.  Three out of four of the patients were boys. A little more than half (54%) had head injuries, 33% had limb injuries…  read on >  read on >

As with any new drug, parents and doctors may worry that the use of GLP-1 weight-loss meds by children and teens might raise psychiatric risks, including the risk for suicide and suicidal thoughts. But a new study involving more than 54,000 U.S. adolescents found no such link. In fact, obese kids who used the drugs had a 33% decline in their risk for thoughts of suicide and suicide attempts compared to adolescents who didn’t, Israeli researchers reported. There could be many reasons driving the boost in mental outlook that comes with the use of drugs like Wegovy (semaglutide), said a team led by Dr. Liya Kerem, of Hadassah University Medical Center in Jerusalem. One is pretty straightforward: “Obesity during adolescence, by itself, is associated with diminished quality of life and increased risk for psychiatric disorders,” the researchers noted. So, as GLP-1 medications help teens shed pounds, their risk for thoughts of suicide may recede. The findings were published Oct. 14 in the journal JAMA Pediatrics. Sales of GLP-1 weight-loss medications like Wegovy and Zepbound (tirzepatide) have boomed among adults, and with 1 in every 5 U.S. children now obese, the drugs’ uptake by adolescents is also surging. However, Kerem’s team said the data on whether or not GLP-1 meds might trigger depression and other psychiatric issues has been mixed. “Suicide is the second most prevalent…  read on >  read on >