COVID-19 boosters may be offered this fall, but first scientists need to determine what strains to target and who should receive the shots. Advisers to the U.S. Food and Drug Administration are slated to meet Thursday to discuss plans for fall, a decision with a deadline because drugmakers will need to have the time to manufacture the shots, NBC News reported. The process is similar to deciding on an annual flu vaccine. FDA scientists said redesigned boosters should target at least one variant of XBB, according to briefing documents published Monday. XBB strains have been spreading since last fall and are related to an omicron subvariant. “These data suggest that an updated strain composition of COVID-19 vaccines to more closely match currently circulating omicron sublineages is warranted for the 2023-2024 vaccination campaign,” the scientists wrote. The World Health Organization and the European Medicines Agency have both said a booster should target an XBB subvariant. As the virus has changed, vaccines have evolved, from a shot in December 2020 that targeted the original virus to FDA-approved shots last fall that targeted the original COVID strain as well as the omicron subvariants BA.4 and BA.5. XBB 1.5 is the dominant strain now circulating, with 40% of new cases having this strain, according to the U.S. Centers for Disease Control and Prevention. About 18% of new cases have… read on > read on >
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Stress that Farm Families Face Affects Parents, Kids Alike
While the challenges of farm work are well noted, the stressors affect not just the mental health of adults, but also their teenage children, according to new research. In results from the first year of a five-year study, researchers found that 60% of both adults and teens on U.S. farms met the criteria for at least mild depression. About 55% of the adults and 45% of the teenagers had symptoms of generalized anxiety disorder. “There’s a lot of young people growing up on a farm and participating in agricultural work. We’ve long acknowledged the inherent hazards of this work environment, and now we’re also recognizing its impact on mental health,” said researcher Josie Rudolphi, Illinois Extension specialist and assistant professor in the College of Agricultural, Consumer and Environmental Sciences at the University of Illinois Urbana-Champaign. “Most of the work on farm stress and mental health is primarily focused on adult farmers. However, it is important to recognize that children are fully aware of what’s happening on the farm, and they are not immune to the stressors that exist,” Rudolphi said in a university news release. The researchers gathered data through online surveys of farmers and their children ages 13 to 18 throughout the United States. They used something called the Family Stress Model, developed in Iowa in the 1990s as a way to look at… read on > read on >
Low-Fat Breakfasts Could Weaken Effect of a Key Lung Cancer Drug
The lung cancer drug alectinib (Alecensa) is more potent when taken with a fuller breakfast, or lunch, than when taken with a low-fat breakfast, researchers report. The Dutch team evaluated 20 patients who took one of two daily doses of alectinib with either low-fat yogurt alone, a full continental breakfast, or a lunch of their choosing. Low-fat yogurt resulted in 14% less exposure to the drug than a continental breakfast, and 20% less than lunch, the researchers found. The report was published June 12 in the JNCCN, Journal of the National Comprehensive Cancer Network. “This is important information for patients, since we know that higher alectinib concentrations in blood could result in more efficacy of the drug, a longer treatment duration and therefore, hopefully, a better survival,” said lead researcher Daan Lanser, from the Erasmus Cancer Institute at Erasmus University Medical Center in the Netherlands. “Sometimes, we hear that patients are advised to take their twice daily alectinib strictly 12 hours apart, with the result that some patients will take it with just a small snack in the morning or evening. We believe that taking it with a substantial meal containing enough fat is far more important for the absorption and efficacy of the treatment than to wait 12 hours between doses,” Lanser said in a journal news release. “This important study highlights the key… read on > read on >
Temptation Alley: Checkout Counters Are Prime Spots for Unhealthy Food
Every grocery shopper must pass through the “temptation alley” that is the checkout aisle, surrounded by candy bars, salty snacks and sugary sodas. Those who’d like a healthy option for an impulse buy while they wait in line — fruit, veggies, nuts or water — will be left wanting, a new study says. About 70% of foods and beverages offered at checkout stands are unhealthy, according to a new study in Current Developments in Nutrition. Further, 9 out of 10 (89%) snack-sized options in the checkout aisle are junk food, researchers found. The presence of so much junk food in the checkout lane is calculated, said lead researcher Jennifer Falbe, an associate professor of nutrition and human development at the University of California, Davis. “Many of us go shopping thinking that we make choices in a neutral environment, but our findings indicate that is not the case,” Falbe said. “Certain products are preferentially promoted over others — in this case, unhealthy products at the checkout — and this can affect consumer decisions.” Prior research has shown that items offered there aren’t necessarily in high demand by consumers or represent a high profit margin for the supermarket, Falbe said. “What you see at checkout is often there because a big food or beverage company paid the store to place their products there,” Falbe said. “The checkout… read on > read on >
A Little Drinking Might Help the Heart, and Scientists Think They Know Why
Many studies have suggested that light drinking can do the heart some good, and now researchers think they have found one reason why: It helps the brain relax. It’s no secret that many people pour a drink as a way to unwind and shed the stressors of the day. And research suggests that is not just a placebo effect. In the short term, alcohol has a quieting effect on the amygdala — a brain area that processes potential threats in our surroundings. Now the new study shows that amygdala activity is habitually dialed-down in moderate drinkers, relative to non-drinkers. And that appeared to partially account for their lower risks of cardiovascular ills, including heart attack and stroke. The findings, published in the June 2023 issue of the Journal of the American College of Cardiology, add to a large body of evidence connecting moderate drinking to a lower heart disease risk. “Moderate” is generally defined as no more than one alcoholic drink per day for women, and no more than two per day for men. No one, however, is suggesting that people drink for the sake of their heart health, experts stressed. For one, alcohol can clearly have harms. There’s the potential for abuse and dependency, and heavy drinking is known to be detrimental — including to the brain. Even moderate drinking can carry health risks,… read on > read on >
Microplastics You Inhale Are Getting Lodged in Airways
Humans are inhaling microplastics from the degradation of plastic products in the environment, and these tiny plastic particles are sticking in human airways, according to researchers. People inhale about 16.2 bits of these microplastics every hour — the equivalent of a whole credit card each week — according to a study published June 13 in Physics of Fluids. These microplastics usually contain toxic chemicals. “This study emphasizes the need for greater awareness of the presence and potential health impacts of microplastics in the air we breathe,” study co-author YuanTong Gu said in a journal news release. He’s a professor at Queensland University of Technology in Australia. Millions of tons of these microplastic particles have been found in water, air and soil, the researchers noted. Global microplastic production is surging, and in 2022 studies found microplastics deep in human airways, raising the concern of serious respiratory health hazards, they pointed out. The international team of researchers developed a computational fluid dynamics model to analyze microplastic transport and deposits in the upper airway. These microplastics tended to collect in hot spots in the nasal cavity and the back of the throat, the study showed. They were 1.6, 2.56 and 5.56 microns in size and spherical, tetrahedral and cylindrical in shape. The team also looked at movement during slow and fast breathing conditions. The complicated and highly asymmetric… read on > read on >
Nearly 15% of School-Age Children in U.S. Have Received Mental Health Treatment
About one in every seven American kids aged 5 to 17 underwent some form of mental health treatment in 2021, the latest year for which statistics are available. So finds a new report from researchers at the U.S. Centers for Disease Control and Prevention, which pegs the percentage of kids who got mental health care in 2021 at 14.9%. Rates of mental health care were higher among older kids (aged 12 to 17), nearly 19% of whom received treatment over the prior year, than they were for children aged 5 to 11 (just over 11%). The new statistics don’t necessarily mean that more American children are suffering from mental illness, but it could mean that more are receiving the care they need, one expert said. “I have a report from 2015 that suggests that 49% of U.S. children have a mental health disorder of some kind, may it be ADHD [attention-deficit/hyperactivity disorder], anxiety, depression, autism spectrum,” said Mary Karapetian Alvord, a psychologist who practices in Chevy Chase, Md. “But at that time, the stat was that only 7.4% [of these children] actually received one treatment within the year. So there’s definitely, I think, more access now, more availability.” However, another expert said the new numbers could reflect an increase in mental health troubles among kids. “Following the pandemic, we have seen substantial increases in mental… read on > read on >
Weight-Loss Surgery Could Bring Weaker Bones to Teens
Weight-loss surgery can have a lot of benefits for obese teens and young adults. But a new study finds a concerning side effect. Young people who had sleeve gastrectomy, the most common obesity surgery, also had weakened bones. That doesn’t mean they shouldn’t get the operation, said lead author Dr. Miriam Bredella, a professor of radiology at Harvard Medical School. Rather, the research could lay the foundation for new therapies to target this bone issue, while teens continue to help preserve their bone strength with supplements, a healthy diet and weight-bearing exercise. Although weaker bones can mean higher risk of fractures, obesity is tied to diabetes and heart disease, Bredella said. “Knowing what we know now and in the studies on hormones, maybe this will represent a target for new therapies that can improve bone health,” Bredella said. A growing problem Obesity is a growing problem in the United States, where 22% of 12- to 19-year-olds are obese, according to the U.S. Centers for Disease Control and Prevention. The American Academy of Pediatrics, a leading medical group, recommends that teens with severe obesity be evaluated for metabolic or bariatric (weight-loss) surgery. Also, starting at age 12, kids can be offered weight-loss medication, in addition to recommended lifestyle changes, the academy says. Sleeve gastrectomy works by removing between 75% and 80% of the stomach, restricting how… read on > read on >
Topical Gel for Erectile Dysfunction Gets FDA Approval for Over-the-Counter Sale
Men with erectile dysfunction will now have the option of using a topical gel to treat the condition. The U.S. Food and Drug Administration has approved over-the-counter marketing for the product, called Eroxon, as a first-of-its-kind medical product. The British pharmaceutical firm Futura Medical makes the gel. “FDA set a very high standard in evaluating the effectiveness and safety of De Novo Medical Devices. I am delighted that we met this standard,” Futura CEO James Barder said in a news release on Monday. About 30 million American men are affected by erectile dysfunction, where they’re not able to get or keep an erection for sexual activity. This new gel will be sold in a single-dose tube, CNN reported. It should be applied to the head of the penis before sex. Users may be able to become erect within 10 minutes and maintain that for long enough to have sex in about 65% of those who use it, according to the company. The product is already sold in Belgium and the United Kingdom, where it costs the equivalent of $31.22 in U.S. dollars for a four-pack, CNN reported. “We don’t have specific pricing details yet, as the pricing will ultimately be determined by the partner who launches Eroxon in the U.S.,” a company spokesman told CNN. The timeline for when the product will be in the… read on > read on >
Millions Still Haven’t Recovered Full Sense of Smell After COVID
COVID caused more than 20 million Americans to lose their ability to smell and taste, and at least 25% haven’t regained those vital senses, a new study says. Survey responses from nearly 29,700 adults also show a correlation between more severe COVID infection and taste and smell loss, researchers reported recently in the journal The Laryngoscope. “The value of this study is that we are highlighting a group of people who have been a bit neglected,” said study co-author Dr. Neil Bhattacharyya, a professor of otolaryngology at Massachusetts Eye and Ear. “Losing your sense of smell or taste isn’t as benign as you may think. It can lead to decreased eating for pleasure and, in more extreme cases, it can lead to depression and weight loss,” he added in a journal news release. One motivation for the study was a patient who lost 50 pounds due to his loss of smell, Bhattacharyya said. “The patient wasn’t eating and became very sick and very depressed because of the loss of smell,” Bhattacharyya said. “When you hear about COVID-related smell loss, you think most people get it back and are fine. But there is a substantial number of people who don’t recover it.” Using data from the 2021 National Health Interview Survey, the researchers found that about 60% of participants infected with COVID had a loss of… read on > read on >