
Not sure what’s causing your child’s asthma? A new quick-and-easy nasal swab test for kids can diagnose the specific immune system drivers behind their asthma, potentially opening the door to better treatments, researchers say. The test diagnoses a child’s asthma subtype, also called an endotype. “Because asthma is a highly variable disease with different endotypes, which are driven by different immune cells and respond differently to treatments, the first step toward better therapies is accurate diagnosis of endotype,” senior researcher Dr. Juan Celedon, chief of pulmonary medicine at the UPMC Children’s Hospital of Pittsburgh, said in a news release from the hospital. Asthma is the most common chronic disease of childhood, affecting about 1 in every 10 kids, according to the National Institutes of Health. Traditionally, doctors classify asthma into different subtypes based on the immune cells that are causing inflammation that chokes off airways. There’s T2-high driven by T helper 2 cells, T17-high driven by T helper 17 cells, and low-low in which neither type of cell appears to be the cause. Precisely diagnosing an asthma subtype involves putting a kid under anesthesia and taking a small sample of lung tissue, which is then subjected to genetic analysis, researchers said. That procedure is so invasive that it’s just not worth it for kids with milder asthma, so doctors instead must guess asthma subtype based… read on > read on >