All Sauce from Weekly Gravy:

Children and adults with a rare type of soft tissue cancer will now have a new treatment option that could have a big impact. The U.S. Food and Drug Administration has approved the immunotherapy drug atezolizumab (Tecentriq) for use in patients with advanced alveolar soft part sarcoma (ASPS) that has spread to other parts of the body or cannot be removed by surgery. “This approval will make a huge impact in terms of a rare disease that has been particularly challenging to treat,” said Dr. Alice Chen, of the Developmental Therapeutics Clinic in the U.S. National Cancer Institute’s (NCI) Division of Cancer Treatment and Diagnosis (DCTD). This cancer begins in the soft tissue that connects and surrounds the organs and other tissues. It spreads slowly, but is typically deadly once it spreads. Chemotherapy doesn’t work against it and new targeted treatments, including drugs called tyrosine kinase inhibitors, do not have lasting effectiveness. About 80 people in the United States receive an ASPS diagnosis each year. About 50% of patients with metastatic disease are still alive after five years. The cancer mostly affects adolescents and young adults. The approval was granted following the results of a non-randomized phase 2 trial led by the NCI, part of the U.S. National Institutes of Health (NIH). The drug is approved for people aged 2 and up. About 40% of…  read on >  read on >

Keeping allergies and asthma in check in the new year is a resolution worth keeping. With 2023 dawning, the American College of Allergy, Asthma and Immunology offers some suggestions for keeping symptoms under control all year long. “More than 50 million people in the U.S. suffer from allergic conditions,” said allergist Dr. Kathleen May, president of the ACAAI. “That’s a lot of Americans who need to be mindful of staying healthy to keep symptoms under control,” May added in a college news release. “Taking a few moments before the new year begins to consider how you’ll keep yourself on top of sneezing and wheezing in 2023 is well worth your investment of time. It’s a valuable way to get your year off to a great start.” At the top of the ACAAI tip list: Eat right to avoid food allergens. If you have a food allergy, you already know to steer clear of problem foods. You should also always carry two epinephrine auto injectors with you and make sure they are up to date. Also, encourage teens and college kids to educate their friends about food allergies, making them allies in safety from anaphylaxis. Make an appointment to see your allergist if the pandemic has caused you to stay away. Keep medications current and pay attention to whether your prescriptions are working for your symptoms.…  read on >  read on >

New Year’s resolutions can be a fickle thing. They are a time-honored way to promise improvements to yourself and your behavior, a “fresh start” to the new year. But if chosen poorly, a resolution also can be a source of anxiety, disappointment and hopelessness. “They tap into the abiding American spirit of relentless self-improvement, and that can be so relentless that it translates into additional stress,” said John Norcross, chair of psychology with the University of Scranton in Pennsylvania and author of “Changeology: 5 Steps to Realizing Your Goals and Resolutions.” About one in four Americans cite their resolutions as a source of anxiety heading into the new year, according to a new poll by the American Psychiatric Association. Choosing an appropriate resolution — and realistic ways to follow through on it — can help relieve some of that stress, experts say. Resolutions tend to focus on a few specific areas — health, money and relationships, Norcross said. “The number one difficulty we encounter is that people make truly unrealistic, grandiose expectations,” Norcross said. Still, it makes sense that people would set lofty goals for themselves as the year turns, said Dr. Rebecca Brendel, president of the American Psychiatric Association. “There’s this temptation when the year switches from 2022 to 2023, then it’s a fresh start and everything in the past is all history,” Brendel…  read on >  read on >

FRIDAY, Dec. 30, 2022 (HealthDay News) – The United States could see a huge rise in diabetes among young people over the next several decades, a new modeling study finds. As many as 220,000 young people under the age of 20 could have type 2 diabetes in 2060, which would represent a nearly eight-fold increase, a research team that included scientists from the U.S. Centers for Disease Control and Prevention found. Type 1 diabetes cases could increase, too, by as much as 65% in the next 40 years. Even if the rate of new diabetes diagnoses among young people stayed unchanged, type 2 cases could increase nearly 70% and type 1 cases by 3% by 2060. “This new research should serve as a wake-up call for all of us. It’s vital that we focus our efforts to ensure all Americans, especially our young people, are the healthiest they can be,” CDC Acting Principal Deputy Director Dr. Debra Houry said in an agency news release. “The COVID-19 pandemic underscored how critically important it is to address chronic diseases, like diabetes. This study further highlights the importance of continuing efforts to prevent and manage chronic diseases, not only for our current population but also for generations to come.” The study authors used findings from the Search for Diabetes in Youth survey, which was funded by the CDC…  read on >  read on >

A new study confirms what many believe: Women tend to be better than men at imagining or understanding what another person is feeling or thinking. Using a test that measures empathy, researchers evaluated more than 300,000 people in 57 countries around the world to come to that conclusion. “Our results provide some of the first evidence that the well-known phenomenon — that females are, on average, more empathic than males — is present in a wide range of countries across the globe. It’s only by using very large data sets that we can say this with confidence,” said study author David Greenberg, from Bar-Ilan University in Israel. The study was led by Cambridge University in England and included collaborators from Bar-Ilan and Haifa universities in Israel, as well as Harvard and Washington universities in the United States, and IMT School for Advanced Studies in Lucca, Italy. The test used in the study is one of the most widely used for measuring empathy. It asks participants to choose a word best describing what a person in a photo is thinking or feeling just by viewing photos of the eye region of the face. This new study found that females scored significantly higher than males, on average, in 36 countries. Females scored similarly to males in 21 countries. In no country did males score significantly higher than…  read on >  read on >

The U.S. Food and Drug Administration’s approval process for the controversial Alzheimer’s drug Aduhelm was “rife with irregularities,” despite lingering doubts about the power of the pricey medication to slow the disease down, a Congressional report released Thursday claims. Actions the agency took with Biogen, maker of Aduhelm, “raise serious concerns about FDA’s lapses in protocol,” the report concluded. But the 18-month investigation launched by two congressional committees also took Biogen to task for setting too high a price on the medication. Company documents showed Biogen officials settled on an annual cost of $56,000 for Aduhelm because it wanted to “establish Aduhelm as one of the top pharmaceutical launches of all time,” even though it knew the high price would burden Medicare and patients, the report found. Not only that, Biogen planned to spend up to several billion dollars on an aggressive marketing campaign to target doctors, patients, advocacy groups, insurers, policymakers and communities of color, who were drastically underrepresented in the company’s clinical trials of the drug. The controversy over Aduhelm (aducanumab) stretches back to its June 2021 approval. The Cleveland Clinic and the U.S. Department of Veterans Affairs, among others, decided not to offer Aduhelm infusions following the approval because of the drug’s questionable efficacy and risks of brain swelling and bleeding. Once Medicare sharply limited its coverage of Aduhelm, still expensive after…  read on >  read on >

Most working-age Americans get health insurance through their employer, but even they are finding it tougher to afford medical care these days, a new study shows. Researchers found that over the past 20 years, a growing number of Americans with job-based health insurance have been skipping medical care due to costs. Women have been particularly hard-hit. The study, published Dec. 27 in the Journal of the American Medical Association, could not get at the reasons. But experts said there are some likely explanations, including rising health care costs and moves by insurance plans to foist more payment responsibility onto consumers. “The U.S. health care system is unique in how privatized it is,” said lead researcher Avni Gupta, a PhD student at the NYU School of Global Public Health in New York City. About 61% of Americans younger than 65 get health insurance through their employer, and businesses use that benefit to help attract workers, Gupta pointed out. “It’s the most important fringe benefit of employment,” she said. But increasingly, the new findings show, that fringe benefit is falling short. By 2020, the study found, about 6% of U.S. women with employer-sponsored insurance said they’d been forced to skip needed medical care in the past year due to costs. That was double the percentage 20 years before, at 3%. The figures were lower among men, but…  read on >  read on >

Adding climate-impact labeling to fast-food menus can have a big effect on whether or not consumers go “green” when eating out, new research suggests. The finding is based on an online survey that asked consumers to order virtual meals after randomly looking over menus that either had some form of climate labeling or none at all. The result: Compared with those who chose from a regular, non-labeled menu, 23.5% more who ordered from a menu that flagged the least green choices ended up making a “sustainable” meal choice. (That’s another way of saying, for example, that they steered clear of red meat — a food whose production has a big climate impact.) Similarly, about 10% more of respondents made more sustainable choices when reviewing menus that indicated the greenest meals available. “Sustainability or climate change menu labels are relatively new, and have not yet been implemented in fast-food restaurants,” said lead author Julia Wolfson, an associate professor of human nutrition at Johns Hopkins Bloomberg School of Public Health in Baltimore. “However, other kinds of labels, such as calorie labels, have been in restaurants for some time now.” Other studies have shown that such labels do affect food ordering decisions. With that in mind, her team wanted to see if climate labels might be equally effective. And — if so — “whether positively or negatively framed…  read on >  read on >

Made infamous as the club drug Special K, ketamine is nowadays being seen as a wonder drug for some folks with hard-to-treat depression. However, a new study finds that some types of patients are more likely to gain a rapid and significant benefit from ketamine than others. Overall, while most patients did benefit from the drug, about one-third experienced a “rapid improvement” in their depression symptoms, the researchers said. Certain patient characteristics appeared to predict that level of benefit. “Severely depressed individuals with a history of childhood trauma may have a better likelihood of a rapid and robust response to ketamine,” concluded lead researcher Brittany O’Brien, an assistant professor of psychiatry and behavioral sciences at Baylor College of Medicine in Houston. In 2019, the U.S. Food and Drug Administration approved a ketamine derivative called esketamine (Spravato) for depression that has failed to respond to at least two conventional antidepressants. Given as a nasal spray, esketamine is different from ketamine, which is an injectable anesthetic that can have mind-altering effects. The new study included nearly 300 people with major depression who were treated with three infusions of ketamine at an outpatient clinic. Participants were 40 years old, on average, and most were men. They had not responded to at least two antidepressants in the past. Mood changes were measured using a standardized depression scale over six…  read on >  read on >

THURSDAY, Dec. 29, 2022 (HealthDay News) – All travelers flying from China to the United States will soon be required to produce a negative COVID test or show proof of recovery if they’ve had a recent COVID infection, U.S. health officials announced Wednesday. The new rule, set to go into effect on Jan. 5, was created in response to a surge in COVID cases in China and the “lack of adequate and transparent epidemiological and viral genomic sequence data being reported from” that country, the U.S. Centers of Disease Control and Prevention said in an agency news release. “What we want to avoid is having a variant enter into the U.S. and spread like we saw with Delta or Omicron,” Matthew Binnicker, director of clinical virology at the Mayo Clinic in Rochester, Minn., told the Associated Press. The new requirement applies to people aged 2 and older flying from China and the Special Administrative Regions of Hong Kong and Macau. It also applies to those who’ve been in China within the past 10 days and are flying to the United States through Incheon International Airport in South Korea, Toronto Pearson International Airport and Vancouver International Airport, both in Canada. Those three airports account for the majority of plane passenger traffic from China and its surrounding regions, the CDC noted. Passengers will need to supply a…  read on >  read on >