Taking a daily low-dose aspirin may speed the progression of cancer in the elderly, a new clinical trial shows. Daily aspirin doubled the risk that a person 70 or older would die from a stage 3 cancer, and increased the death risk associated with stage 4 cancers by nearly a third, according to data from more than 19,000 older people in the United States and Australia. Older patients taking daily aspirin also had a roughly 20% increased risk of their cancer spreading to other parts of their body either before or after diagnosis, the researchers found. Compelling evidence from earlier clinical trials had shown that daily aspirin taken by middle-aged folks could reduce the risk of cancer, particularly colon cancer, researchers said in background notes. But in this new trial, the investigators found that elderly people who presented with later-stage cancers “tended to do worse if they were on aspirin,” said senior researcher Dr. Andrew Chan, director of epidemiology at the Massachusetts General Hospital Cancer Center, in Boston. “It does suggest there is a potential difference in the effect of aspirin on older adults compared with younger adults.” Based on these new findings, older people should have a serious discussion with their doctor before starting a course of low-dose daily aspirin, said Dr. Frank Sinicrope, a gastrointestinal cancer specialist with the Mayo Clinic in Rochester,… read on >







