Using a weight-loss medication to help you shed pounds gradually appears to help extend life for people with arthritis of the hips or knees, a new study finds. However, folks with arthritis who dropped pounds very quickly showed no benefit in terms of survival, and even a slight uptick in their risk for heart disease, a team of American and Chinese researchers found. The study’s take-home message: “Gradual weight loss by anti-obesity medications may improve the overall wellness of overweight or obesity patients with knee or hip osteoarthritis,” concluded a team led by Jie Wei of Central South University in Changsha, China. The findings were published recently in the journal Arthritis & Rheumatology. Obesity can exacerbate arthritis in the joints, and is a known risk factor for an early death. In the new study, Wi’s group tracked outcomes for over 6,500 British people, aged 40 or older, who were overweight or obese and also had knee or hip arthritis. Some took weight-loss drugs to help them shed excess pounds. Wei’s team tracked their outcomes for various health conditions and death over a five-year period. The data was collected between 2000 and March of 2022 — before the advent of blockbuster weight-loss medications such as Wegovy and Zepbound. Instead, patients were taking drugs such as orlistat (Alli), sibutramine and rimonabant (Zimulti) to help them get slimmer.…  read on >  read on >

Even Valentine’s Day apparently doesn’t trump the start of a brand new year when it comes to getting frisky. Sales of the morning-after pill surged across the U.S. after New Year 2022, new research shows. Nearly 41,000 extra pills were sold in the following week, a period linked to increased risks of unprotected sex.  Sales of emergency contraception also rose after other holidays such as Valentine’s and Independence Day but not as much, a team led by Brandon Wagner of Texas Tech University report in the Christmas issue of the BMJ. While the annual New Year’s sale spike might seem funny,  Wagner’s team points out in a journal news release that “it  is indicative of unmet contraceptive need that calls for further attention” amid tightened restrictions on abortions in many U.S. states. The increased sexual activity associated with New Year’s is less likely to be protected due to increased drinking, they point out. New Year’s Eve has also been linked to increased rates of sexual assault and limited access to other forms of birth control because clinics, medical offices and shops close early or altogether. For the new study, researchers analyzed retail scan data for levonorgestrel, an over-the-counter medication available without age restrictions.  While effective when taken within as many 96, and possibly 120, after unprotected sex, it’s more likely to work the sooner it…  read on >  read on >

Dozens of over-the-counter lubricating eyedrops and artificial tears faced recall in 2023, due to contamination and unsafe manufacturing practices. “This year, we’ve seen an especially large number of recalls in ophthalmologic products,” said Gary Novack, a clinical professor with the UC Davis Health Department of Ophthalmology and Vision Sciences in Davis, Calif. People who regularly use eye drops to fend off dry eyes or help with contact lenses should be aware of these recalls, and take steps to protect themselves, Novack said. “Now that the public health emergency phase of the pandemic is over, the FDA is doing more inspections and they are finding a number of issues at manufacturing plants,” Novack explained in a university news release. The recalls began in February with three brands taken off shelves, including one linked to serious infections, vision loss and four deaths, Novack said. “It’s very rare to get infections from eye drops. However, what we learned this year is that it can happen,” Novack said. “It’s serious not only for potentially losing vision, but in some rare cases patients developed systemic infections and died.” Additional recalls followed in August, October and November, leaving consumers confused about whether any over-the-counter eye drops are safe to use. Products like eye drops are particularly tricky to manufacture because they need to be sterile and germ-free, and they must be…  read on >  read on >

Doctors who overprescribe antibiotics are often blamed for medication-resistant illnesses, but new research points to another potential culprit: air pollution. Controlling air pollution could reduce antibiotic resistance, greatly reducing deaths and economic costs, according to a new in-depth global analysis were published Aug. 7 in The Lancet Planetary Health.. “Antibiotic resistance and air pollution are each in their own right among the greatest threats to global health,” said lead author Hong Chen, a professor at Zhejiang University in China. “Until now, we didn’t have a clear picture of the possible links between the two, but this work suggests the benefits of controlling air pollution could be twofold: Not only will it reduce the harmful effects of poor air quality, it could also play a major role in combatting the rise and spread of antibiotic-resistant bacteria,” Chen said in a journal news release. Some potential pathways include hospitals, farms and sewage-treatment facilities that emit and spread antibiotic-resistant particles through the air and across distances, the study found. Evidence suggests air pollution contributes to the spread of this antibiotic-resistant bacteria, according to the study. Sources of air pollution called PM2.5 include industrial processes, road transportation and domestic coal and wood burning. About 7.3 billion people globally are directly exposed to unsafe average annual PM2.5 levels. About 80% of those people live in low- and middle-income countries, the…  read on >  read on >