A new brain scanning technique is shaking up what researchers thought they knew about Alzheimer’s disease. Researchers now say they can predict with reasonable accuracy which brain regions will wither and atrophy in Alzheimer’s by identifying the places where tau protein “tangles” have built up. “You could really predict which brain regions were going to get damaged just on the basis of the tau scans we took at the beginning of the study,” said lead researcher Renaud La Joie, a postdoctoral fellow at the University of California, San Francisco, Weill Institute for Neurosciences. “Where the tau was built up at the beginning of the study was very predictive of where the actual brain shrinkage was going to happen in the next year or two.” These findings support the growing contention that toxic tau proteins drive brain degeneration in Alzheimer’s more directly than the disease’s other hallmark, amyloid protein plaques, the study authors said. The scans also could allow doctors to predict how Alzheimer’s will affect individual patients, by tracking which brain regions have more accumulated tau tangles, La Joie said. “If you use tau scans in this group of patients with Alzheimer’s disease, it might actually help you have very precise expectations and very precise measures of what’s going to happen to the patient,” he said. For example, doctors might be able to predict which… read on >







