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Mounjaro outperforms Ozempic in helping people lose weight, a new study shows. People taking tirzepatide (Mounjaro, Zepbound) dropped significantly more pounds than those taking semaglutide (Ozempic, Wegovy), researchers reported July 8 in the journal JAMA Internal Medicine. “Individuals with overweight or obesity treated with tirzepatide were significantly more likely to achieve clinically meaningful weight loss and larger reductions in body weight compared with those treated with semaglutide,” concluded the research team led by Dr. Nicholas Stucky, vice president of research with Truveta Inc., a medical research collective. For the study, researchers tracked more than 18,000 overweight and obese people who were prescribed either drug to help control their type 2 diabetes between May 2022 and September 2023. Both drugs initially were developed as type 2 diabetes medications, but were later approved for use in weight loss. Results show that both drugs are effective in promoting some weight loss. Nearly 82% of patients taking Mounjaro lost 5% or more of their body weight, compared to nearly 67% of those taking Ozempic, researchers found. However, Mounjaro users were more likely to achieve greater weight gain. About 42% of Mounjaro patients lost 15% or more of their body weight, compared to about 18% of those taking Ozempic. Overall, patients on Mounjaro were 76% more likely than those on Ozempic to lose 5% or more of their body weight; 2.5…  read on >  read on >

In yet another finding that touts the health benefits of wildly popular weight-loss medications like Wegovy and Ozempic, scientists report that taking the drugs may help reduce the risk of some cancers. In a study published July 5 in JAMA Network Open, researchers found people with type 2 diabetes who were being treated with a class of GLP-1 drugs were less likely to be diagnosed with 10 of 13 obesity-linked cancers than those who were taking insulin. The reduction in risk was significant: Taking the medications cut rates of gallbladder cancer, meningioma, pancreatic cancer and hepatocellular carcinoma, a type of liver cancer, by more than half.  Risks were also reduced for cancers of the ovaries, colon, esophagus and kidneys as well as for multiple myeloma (a cancer of the bone marrow) and endometrial cancer (which begins in the lining of the uterus). Excess weight can trigger chronic inflammation and high levels of insulin, insulin-like growth factor and sex hormones. All of these can prompt the development of cancer, according to the U.S. Centers for Disease Control and Prevention. GLP-1 medications interact with systems related to insulin production, the researchers noted. Importantly, the study found that taking GLP-1 drugs did not lower the risk of postmenopausal breast cancer, which CDC data show is the most common obesity-linked cancer. Risk was also not reduced for stomach cancer or thyroid…  read on >  read on >

Researchers have identified a gene that can trigger obesity, behavior problems and postpartum depression when missing or damaged. The finding could lead to new treatments for postpartum depression and overeating: The study in mice suggests the so-called “love hormone” — oxytocin — may ease symptoms.  Obesity and postpartum depression are major health problems worldwide. The new study, published July 2 in the journal Cell, is an outgrowth of research by scientists at Baylor College of Medicine in Houston and the University of Cambridge in the U.K.  They were studying two boys from different families who were severely obese. The boys had autism, anxiety and behavior problems triggered by smells or sounds. Both were missing a gene called TRP5.  They inherited the gene deletion from their mothers, who also were missing the gene. Both women were obese and had experienced postpartum depression. To find out if the missing TRPC5 gene was causing problems in the boys and their moms, researchers put genetic engineering to work. They produced mice with a defective version of the gene — called Trpc5 in mice. “What we saw in those mice was quite remarkable,” said study co-author Dr. Yong Xu, associate director for basic sciences at the USDA/ARS Children’s Research Center at Baylor College of Medicine in Houston. “They displayed very similar behaviors to those seen in people missing the TRPC5…  read on >  read on >

Wartime appears to increase the risk of chronic pain for military women, a new study suggests. Active-duty servicewomen who served between 2006 and 2013 – a period of heightened combat deployments – had a significantly increased risk of chronic pain compared to women serving at other times, according to results published July 5 in the journal JAMA Network Open. Likewise, female family members of military personnel serving in 2006-2013 also were more likely to experience chronic pain, researchers found. “I was surprised by the magnitude of the effect we observed here, particularly among female civilian spouses,” lead researcher Dr. Andrew Schoenfeld, an orthopedic surgeon with Brigham and Women’s Hospital in Boston, said in a news release. “This underscores an overlooked aspect of deployment schedules that the Military Health System must recognize.” About 21% of U.S. adults experience chronic pain, which can persist for months to years, researchers said in background notes. For the new study, researchers analyzed Military Health System medical records for nearly 3.5 million women 18 to 64 from 2006 to 2020. Nearly 325,000 women (9%) had a diagnosis of chronic pain. Researchers divided the women into two groups — those treated from 2006 to 2013, a period of more intense combat exposure, and those treated from 2014 to 2020, when there was significantly less combat exposure. Women in active service from 2006…  read on >  read on >

If you and your partner fall silent when vexing money issues arise, new research suggests you are not alone. A team from Cornell University found that the more stressed people were about their finances, the less likely they were to discuss those concerns with their romantic partners. The findings were published recently in the Journal of Consumer Psychology. “This is the first thing that fascinated us about this topic — that financially stressed individuals who need to have these conversations the most are the least likely to have them,” said study co-author Emily Garbinsky, an associate professor of professor of marketing and management communication at Cornell. Financial stress affects a staggering 70% of Americans, the researchers noted, and includes feelings of being overwhelmed with spending, struggling to meet financial obligations and worrying about money management. Even those who are well-off can struggle with financial anxiety, and this stress makes it tough to have constructive conversations about money with their partners. Not surprisingly, a common strategy is to avoid the sensitive subject completely, the researchers noted. Why? What they discovered was that this avoidance stems from the belief that financial conflicts with a partner are perpetual rather than solvable. In the study, scientists sifted through survey data from thousands of folks who either completed the Consumer Financial Protection Bureau’s National Financial Well-Being Survey or a survey…  read on >  read on >

Millions of Americans struggle to fall or stay asleep, a new survey finds. Some struggle more mightily than others: Roughly 12% of Americans polled said they have been diagnosed with chronic insomnia, the American Academy of Sleep Medicine (AASM) survey revealed. Who was the most likely to miss out on good sleep? Men (13%) were slightly more likely than women (11%) to have been diagnosed with chronic insomnia. Meanwhile, millennials reported the highest rate of chronic insomnia diagnosis (15%). How debilitating can insomnia be? Symptoms associated with insomnia include daytime fatigue or sleepiness; feeling dissatisfied with sleep; having trouble concentrating; feeling depressed, anxious or irritable; and having low motivation or low energy. “Chronic insomnia impacts not just how a person sleeps at night, but also how they feel and function during the daytime,” said AASM President Dr. Eric Olson. “Fortunately, there are effective treatment options for those who are living with chronic insomnia, and these treatments can significantly improve both health and quality of life.” Chronic insomnia can impair physical, mental and emotional health, and it can lead to increased risks for depression, anxiety, substance abuse, motor vehicle accidents, Alzheimer’s disease and type 2 diabetes, experts say. The most effective treatment for chronic insomnia is cognitive behavioral therapy, which combines behavioral strategies such as setting a consistent sleep schedule and getting out of bed when…  read on >  read on >

Going to the gym is good for your overall health, but if you and the gym aren’t practicing good hygiene you could still catch a nasty illness, an expert says. “Good hygiene prevents sicknesses like a cold, influenza and even salmonella, but cleanliness can also indicate that a gym is well-maintained overall, including the quality of equipment,” said Melanie McNeal, a physical and occupational therapy manager at Baylor College of Medicine in Houston. “If hygiene rules are not followed you could get sick, get others sick or even have your membership cancelled.” When going to a new gym for the first time, there are a few key indicators to determine if hygiene is prioritized in the space: A lack of sanitary wipes for members or staff to wipe down equipment after use often means equipment is harboring unseen bacteria No signs posted asking members to clean equipment after using or no cleaning schedule posted suggests cleanliness is not a priority for the gym Other gym members using equipment and not cleaning it afterwards on a consistent basis can show there is not a culture of cleanliness Caked on layers of dust on equipment can indicate that equipment has not been cleaned in a while  Lots of broken-down machines for extended periods of time can be due to a lack of interest from gym management in…  read on >  read on >

It may sound far-fetched, but new research suggests that living in dangerous neighborhoods could trigger an unintended health harm: higher smoking rates among residents. “High levels of neighborhood threat shape perceptions of powerlessness among residents, amplifying a general sense of mistrust, that can promote maladaptive coping behavior like smoking,” said researcher Michael Zvolensky, a professor of psychology at the University of Houston. According to the U.S. Centers for Disease Control and Prevention, the neighborhoods people live in can determine their health and well-being. While such factors are now understood as important factors in the onset, maintenance and relapse of substance use behavior, little research has evaluated what the researchers called “neighborhood vigilance” in terms of smoking rates, the researchers noted. Zvolensky’s team examined the role of neighborhood vigilance in terms of smoking and the severity of problems smokers thought they might face if they try to quit. Living in less secure neighborhoods was tied to smokers thinking it would be tough to quit, expecting “negative mood and harmful consequences,” Zvolensky said in a university news release. These types of neighborhoods were “also associated with more severe problems when trying to quit smoking,” he added. The findings support the notion that dangerous neighborhoods exacerbate “certain negative beliefs about abstinence and challenges in quitting,” Zvolensky said. Participants in the study included 93 adult smokers who were seeking…  read on >  read on >

Amid an ongoing outbreak of bird flu in dairy cows, a fourth case of H5N1 avian flu has been confirmed in another dairy worker, U.S. health officials reported Wednesday. The latest case was reported in Colorado, the U.S. Centers for Disease Control and Prevention said in a news release. “As with previous cases, the person is a worker on a dairy farm where cows tested positive for A[H5N1] virus,” the CDC said. “The person reported eye symptoms only, received oseltamivir [Tamiflu] treatment, and has recovered.” The first two human bird flu cases — the first in Texas and a second in Michigan — also involved only a brief discomfort of the eyes, linked to conjunctivitis, or “pink eye.” Both patients recovered. However, a third case, also reported in Michigan, was the first to present with more typical respiratory symptoms, the CDC noted in a recent health update. That patient has been treated and has since recovered. So far, H5N1 has not been easily passed between people, and all four farm workers became infected after prolonged contact with dairy cows. Despite the fourth case of human bird flu, “this infection does not change CDC’s current H5N1 bird flu human health risk assessment for the U.S. general public, which the agency considers to be low,” the CDC said. “However, this development underscores the importance of recommended precautions…  read on >  read on >

Trendy weight-loss drugs appear to increase the risk of a rare and potentially blinding eye condition, a new study warns. People with diabetes prescribed semaglutide (Ozempic, Wegovy) were more than four times more likely to be diagnosed with NAION, researchers reported July 3 in the journal JAMA Ophthalmology. Further, those who were overweight were more than seven times more likely to be diagnosed with NAION, results showed. “The use of these drugs has exploded throughout industrialized countries and they have provided very significant benefits in many ways, but future discussions between a patient and their physician should include NAION as a potential risk,” said lead researcher Dr. Joseph Rizzo, director of the Neuro-Ophthalmology Service at Mass Eye and Ear in Boston. “It is important to appreciate, however, that the increased risk relates to a disorder that is relatively uncommon,” he added in a hospital news release. NAION typically causes sudden vision loss in one eye, without any pain, Rizzo said. It’s thought to be caused by reduced blood flow to the front of the optic nerve, where the nerve meets the eye. NAION is the most common cause of sudden blindness due to damage of the optic nerve, and is second only to glaucoma as an overall cause of optic nerve blindness, researchers said. There currently are no effective treatments for NAION, and vision loss…  read on >  read on >