When it comes to warding off excess fat, boosting exercise levels while improving your diet may be most effective, rather than focusing on either exercise or diet alone. That’s the finding from a seven-year study of almost 7,300 British adults.  “We found that combining a better diet with more physical activity is an effective way to improve not just weight, but how much and where fat is stored in the body,” noted study lead author Dr. Shayan Aryannezhad. He helped conduct the research while at the University at the University of Cambridge’s Medical Research Council (MRC). There’s an added bonus to the exercise-diet combo, Aryannezhad said, because “it’s particularly effective at reducing the build-up of harmful fat around organs.” He left the MRC’s epidemiology unit earlier this year and is now a clinical research fellow at the University of Oxford.  For the study, Aryannezhad and colleagues wanted to tease out the types of body fat lost under various weight-loss strategies. “When people talk about changes in body weight, they often refer to a single number on the scale,” he explained in a Cambridge news release. “But not all weight loss or gain is the same. First of all, we need to focus on fat mass when considering the risk of metabolic diseases like diabetes and heart disease. Second, body fat is stored in different places, and…  read on >  read on >

When it comes to warding off excess fat, boosting exercise levels while improving your diet may be most effective, rather than focusing on either exercise or diet alone. That’s the finding from a seven-year study of almost 7,300 British adults.  “We found that combining a better diet with more physical activity is an effective way to improve not just weight, but how much and where fat is stored in the body,” noted study lead author Dr. Shayan Aryannezhad. He helped conduct the research while at the University at the University of Cambridge’s Medical Research Council (MRC). There’s an added bonus to the exercise-diet combo, Aryannezhad said, because “it’s particularly effective at reducing the build-up of harmful fat around organs.” He left the MRC’s epidemiology unit earlier this year and is now a clinical research fellow at the University of Oxford.  For the study, Aryannezhad and colleagues wanted to tease out the types of body fat lost under various weight-loss strategies. “When people talk about changes in body weight, they often refer to a single number on the scale,” he explained in a Cambridge news release. “But not all weight loss or gain is the same. First of all, we need to focus on fat mass when considering the risk of metabolic diseases like diabetes and heart disease. Second, body fat is stored in different places, and…  read on >  read on >

People paying out of pocket for Ozempic or Wegovy may soon see lower costs, as Novo Nordisk rolls out new price discounts for its popular GLP-1 medications. The company announced that through the end of March, patients with prescriptions can buy the two lowest doses of Ozempic and Wegovy for $199 a month for two months. After that, the monthly cost rises to $349. The discounts can be accessed through the drugs’ websites and used at pharmacies or through telehealth. The $199 offer only applies to 0.25 mg and 0.5 mg injections. The higher $349 price covers the 1 mg dose of Ozempic and all Wegovy doses. The 2 mg dose of Ozempic is not included. “The US healthcare system is complex, with different types of insurance and various ways for patients to obtain their medicines,” Dave Moore, Novo Nordisk’s executive vice president of U.S. operations, told NBC News. “Our new savings offers provide immediate impact, bringing forward greater cost savings for those who are currently without coverage or choose to self-pay,” he added. These price cuts come as list prices for both medications remain around $1,000 or more per month. They also follow a recent partnership with Costco, which began offering low-dose Ozempic and Wegovy for $499 per month out of pocket. Novo Nordisk has similar cash-pay deals available through CVS, Walmart and its…  read on >  read on >

The brain is thought to be a sterile environment, free from germs. But unexpected deposits of bacteria have been found inside brain tumors, apparently affecting how the cancers grow and behave, a new study says.   “This work opens a new dimension in our understanding of brain tumor biology,” senior researcher Dr. Jennifer Wargo, a professor of surgical oncology and genomic medicine at the University of Texas MD Anderson Cancer Center in Houston, said in a news release. “By mapping how microbial elements influence the brain tumor microenvironment, we may be able to identify new therapeutic strategies to improve outcomes for patients facing these devastating diseases,” Wargo said. For the new study, researchers analyzed 243 brain tissue samples from 221 patients. The samples included 168 from brain tumors and 75 from healthy brain tissue. Using detailed imaging, genetic sequencing and bacterial culturing, researchers unveiled the first evidence of bacteria found within brain tumors, researchers said. The bacteria were found inside both primary brain cancers as well as brain tumors that resulted from a cancer that started elsewhere in the body, results show. Bacteria had previously been found in GI cancers like colon cancer, but there’s been debate about whether such germs are present in tumors found elsewhere in the body. These bacteria appeared to be influencing the cancer’s behavior, potentially helping tumors grow and avoid detection…  read on >  read on >

The brain is thought to be a sterile environment, free from germs. But unexpected deposits of bacteria have been found inside brain tumors, apparently affecting how the cancers grow and behave, a new study says.   “This work opens a new dimension in our understanding of brain tumor biology,” senior researcher Dr. Jennifer Wargo, a professor of surgical oncology and genomic medicine at the University of Texas MD Anderson Cancer Center in Houston, said in a news release. “By mapping how microbial elements influence the brain tumor microenvironment, we may be able to identify new therapeutic strategies to improve outcomes for patients facing these devastating diseases,” Wargo said. For the new study, researchers analyzed 243 brain tissue samples from 221 patients. The samples included 168 from brain tumors and 75 from healthy brain tissue. Using detailed imaging, genetic sequencing and bacterial culturing, researchers unveiled the first evidence of bacteria found within brain tumors, researchers said. The bacteria were found inside both primary brain cancers as well as brain tumors that resulted from a cancer that started elsewhere in the body, results show. Bacteria had previously been found in GI cancers like colon cancer, but there’s been debate about whether such germs are present in tumors found elsewhere in the body. These bacteria appeared to be influencing the cancer’s behavior, potentially helping tumors grow and avoid detection…  read on >  read on >

Listening to your favorite singers may do more than lift your mood — it could also protect your brain. A new study from Australian researchers found that older adults who regularly listened to music had a 39% lower risk of developing dementia compared to those who didn’t make music a part of their daily lives. The research, published recently as part of the ASPREE Longitudinal Study of Older Persons, followed more than 10,000 adults aged 70 and older for about a decade to explore different lifestyle factors linked to healthy aging. “Music was one of the areas we were interested in,” senior researcher Joanne Ryan, head of the Biological Neuropsychiatry and Dementia unit at Monash University, told The Washington Post. Ryan added that they “found that in that time period, they performed better, consistently better, on the tasks of memory and also on a global cognitive function test.” Of the 10,893 participants, about 7,000 said they listened to music most days, and those frequent listeners had the greatest reduction in dementia risk. The study did not specify what type of music was most beneficial. Ryan emphasized that the study can’t prove that listening to music directly prevents dementia, but the results were strong enough to suggest a possible link. She noted music has been shown to boost mood and stimulate multiple areas of the brain.…  read on >  read on >

Listening to your favorite singers may do more than lift your mood — it could also protect your brain. A new study from Australian researchers found that older adults who regularly listened to music had a 39% lower risk of developing dementia compared to those who didn’t make music a part of their daily lives. The research, published recently as part of the ASPREE Longitudinal Study of Older Persons, followed more than 10,000 adults aged 70 and older for about a decade to explore different lifestyle factors linked to healthy aging. “Music was one of the areas we were interested in,” senior researcher Joanne Ryan, head of the Biological Neuropsychiatry and Dementia unit at Monash University, told The Washington Post. Ryan added that they “found that in that time period, they performed better, consistently better, on the tasks of memory and also on a global cognitive function test.” Of the 10,893 participants, about 7,000 said they listened to music most days, and those frequent listeners had the greatest reduction in dementia risk. The study did not specify what type of music was most beneficial. Ryan emphasized that the study can’t prove that listening to music directly prevents dementia, but the results were strong enough to suggest a possible link. She noted music has been shown to boost mood and stimulate multiple areas of the brain.…  read on >  read on >

Want to avoid migraines? Stick to your boring routine, a new study suggests. Any major disruption to a person’s daily routine — called a “surprisal” event — is strongly linked to a higher risk of a migraine attack within the next 12 to 24 hours, researchers reported Nov. 11 in JAMA Network Open. Too much food or drink, staying up late, a stressful incident, unexpected good or bad news or a severe mood swing could pose a “surprise” to the body, setting it up for a next-day migraine, researchers said. “Incorporating measurement of surprisal into migraine forecasting tools could provide individuals with a more effective, personalized strategy for managing headache risk,” concluded the research team led by Dana Turner, an assistant professor of anesthesia, critical care and pain medicine at Harvard Medical School. In fact, the findings support a person-centered approach to treating a migraine “that moves beyond static lists of potential causes to account for the unpredictable and context-sensitive nature of daily life.” For the study, researchers tracked 109 people with migraine from April 2021 to December 2024. Participants kept daily diaries that marked their migraine attacks and any potential migraine triggers they encountered. The research team created an average for each person’s migraine triggers, and then went looking for days on which a “surprise” deviation from that average took place. In their words,…  read on >  read on >

Want to avoid migraines? Stick to your boring routine, a new study suggests. Any major disruption to a person’s daily routine — called a “surprisal” event — is strongly linked to a higher risk of a migraine attack within the next 12 to 24 hours, researchers reported Nov. 11 in JAMA Network Open. Too much food or drink, staying up late, a stressful incident, unexpected good or bad news or a severe mood swing could pose a “surprise” to the body, setting it up for a next-day migraine, researchers said. “Incorporating measurement of surprisal into migraine forecasting tools could provide individuals with a more effective, personalized strategy for managing headache risk,” concluded the research team led by Dana Turner, an assistant professor of anesthesia, critical care and pain medicine at Harvard Medical School. In fact, the findings support a person-centered approach to treating a migraine “that moves beyond static lists of potential causes to account for the unpredictable and context-sensitive nature of daily life.” For the study, researchers tracked 109 people with migraine from April 2021 to December 2024. Participants kept daily diaries that marked their migraine attacks and any potential migraine triggers they encountered. The research team created an average for each person’s migraine triggers, and then went looking for days on which a “surprise” deviation from that average took place. In their words,…  read on >  read on >