An experimental drug appears to outperform the trendy medications Wegovy and Ozempic for both weight loss and diabetes control, a pair of early clinical trials shows. Retatrutide helped people with obesity drop about one-quarter of their starting weight, on average, during 48 weeks taking the drug, according to phase 2 trial results published online June 26 in the New England Journal of Medicine. “What is clear is that 24% weight loss from a single drug has not been seen before,” said co-researcher Dr. Lee Kaplan, an associate professor with Harvard Medical School. “And the subjects in the trial were still losing weight at the end.” The best comparable results come from last year’s clinical trial results for the diabetes drug Mounjaro (tirzepatide), which after 72 weeks had produced an average weight loss of more than 22%, Kaplan said. Retatrutide also helped patients establish better control over their blood sugar levels, according to a second phase 2 trial published online June 26 in The Lancet. Retatrutide works by targeting three different gut hormones that are stimulated by food intake, explained Dr. Ania Jastreboff, director of the Yale Obesity Research Center, in New Haven, Conn. Jastreboff led the obesity trial and was a co-author for the diabetes management trial. The hormones include one targeted by Ozempic and two targeted by Mounjaro, Jastreboff and Kaplan said. “These are…  read on >  read on >

Gastric bypass surgery is a potential long-term cure for type 2 diabetes, especially if the procedure is performed before the disease progresses, a new study argues. Among a large group of obese people with type 2 diabetes, about half achieved remission for an average seven years after undergoing gastric bypass surgery — the longest follow-up ever for such a group, researchers said. “That’s a very big deal,” said senior researcher Dr. Omar Ghanem, a metabolic surgeon with the Mayo Clinic in Rochester, Minn. “After a one-time treatment, you’re going to have a 51% chance that you won’t have diabetes and you won’t have to take any medications for seven years.” The chances of diabetes remission were even better if the disease wasn’t advanced, researchers reported Tuesday at the American Society for Metabolic and Bariatric Surgery’s annual meeting, in Las Vegas. For instance, you stood a better chance of remission if you weren’t taking insulin or multiple diabetes medications, had better blood sugar control, or hadn’t had diabetes for long, researchers found. Also, you didn’t have to lose a lot of weight to stand a good chance of going into remission, researchers said. About 41% of patients who lost the least — less than 18% of their initial weight — following gastric bypass surgery went into remission from their diabetes, results show. By comparison, 56% of…  read on >  read on >

When a child unintentionally shoots and kills another child in the United States, they’ve likely been playing around with an unlocked, loaded gun, new research reveals. Analyzing a decade’s worth of data, researchers also found that 4 out of 10 such gun deaths involve kids 2 to 4 years old. About two-thirds of the unintentional fatal shootings happen at the victim’s home, and both victim and shooter are usually male. Nearly all cases “involve a gun belonging to a parent or other family member that was stored loaded and unlocked,” said study co-author Nichole Michaels. “Often, the child was playing with the gun or thought the gun was a toy,” noted Michaels, an assistant professor of pediatrics at the Ohio State University College of Medicine and the Center for Injury Research and Policy at Nationwide Children’s Hospital in Columbus, Ohio. The critical message is that “these deaths are preventable, and safe storage of firearms is the key,” Michaels said. Guns have surpassed road crashes as the leading cause of death among American children and teens, according to a recent study using data from the U.S. Centers for Disease Control and Prevention. In the new study, investigators used data from the National Violent Death Report System (NVDRS), looking at 279 unintentional fatal shootings that occurred between 2009 and 2018. All the cases involved kids younger than…  read on >  read on >

The pain and discomfort of a herniated disk can significantly impact the quality of your life. Here is what you should know about having a herniated disk, including what it is, its causes, symptoms, diagnosis and treatment. Plus, learn about the medication, self-care, surgery and lifestyle options that may help relieve pain. What is a herniated disk? The Cleveland Clinic describes a herniated disk as a spinal injury. Your spinal cord is made up of bony parts called vertebrae; between the vertebrae are disks that act as cushions. These make it easier to bend and move. When one tears or leaks, it is called a herniated disk. The injury typically occurs in the lower back or neck region. A herniated disk may also be called a slipped disk, a ruptured disk or a bulging disk. Herniated disk causes and risk factors Disk herniation often results from aging; the disks become less flexible over time. The Mayo Clinic lists the following risk factors: Weight: Excess weight puts a strain on the back. Occupation: People with physically demanding jobs that require repetitive lifting, pulling, pushing and bending are more likely to have a herniated disk. Genetics Smoking: It is believed smoking lessens the oxygen supply to the disks and may cause them to break down more quickly. Frequent driving: Sitting for long periods can put pressure on…  read on >  read on >

After drugmaker Novo Nordisk tweaked its diabetes drug Ozempic into Wegovy — a formulation expressly designed to help users shed pounds — sales of both drugs skyrocketed. Other pharmaceutical giants took notice, and over the past weekend the results of multiple clinical trials from would-be competitors were unveiled at this year’s annual meeting of the American Diabetes Association (ADA). Published simultaneously in The Lancet and the New England Journal of Medicine, trials of two diabetes drugs from Eli Lilly — Mounjaro, an injected drug which is already available to patients, and orforglipron, still in clinical trial — each showed effectiveness in helping users drop pounds. Also presented at the meeting and published in The Lancet, Novo Nordisk released the results of a trial of its new investigational drug, dubbed CagriSema, which contains semaglutide (Ozempic) plus a newer medication, cagrilintide. In that trial, the drug helped people with type 2 diabetes shed excess weight. Orforglipron Lilly’s experimental drug orforglipron comes from the blockbuster class of diabetes/weight-loss meds called glucagon-like peptide-1 agonists (GLP-1 agonists) that include Ozempic and Wegovy. However, unlike the latter two drugs, orforglipron is administered as a once-a-day pill rather than an injection, which should make it much more attractive to users. In one phase 2 trial, published online June 23 in the New England Journal of Medicine, 272 adults with overweight or obesity…  read on >  read on >

Smartphones are already handy devices, but researchers have now developed an additional use for them — to check for a fever. An app called FeverPhone is the first ever to transform a smartphone into a personal thermometer without adding new hardware to the device, according to its developers from the University of Washington (UW). The app uses the phone’s touchscreen and repurposes existing battery heat sensors to gather data and estimate a person’s core body temperature, researchers report. The app estimated body temperatures in 37 patients in an emergency room with accuracy comparable to some consumer thermometers. The findings were published recently in the Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies. FeverPhone needs more training data to be widely used, but the technology holds great potential for helping people track their health, the researchers said. “People come to the ER all the time saying, ‘I think I was running a fever.’ And that’s very different than saying ‘I was running a fever,’” said co-researcher Dr. Mastafa Springston, a UW clinical instructor in the Department of Emergency Medicine. “In a wave of influenza, for instance, people running to the ER can take five days, or even a week sometimes. So if people were to share fever results with public health agencies through the app, similar to how we signed up for COVID…  read on >  read on >

If you have had a sharp pain shooting down one leg, you may be experiencing a condition called sciatica. Here is what you need to know about sciatica, including what it is, its causes, symptoms and treatments. Plus, learn about medications, self-care and stretches that may provide relief. What is sciatica? Sciatica refers to pain that travels along the path of the sciatic nerve. The sciatic nerve travels from the lower back through the hips and buttocks and down each leg. The pain may be severe but usually clears up in a few weeks. Sciatica nerve pain causes and risk factors Causes of sciatic nerve pain include anything that affects the sciatic nerve, according to Penn Medicine: Slipped or herniated disk Spinal stenosis Piriformis syndrome Pelvic injury or fracture Tumors Spondylolisthesis The Cleveland Clinic notes that risk factors include: A current or previous injury Normal wear and tear Excess weight or obesity Insufficient core strength Your job Type 2 diabetes Physical inactivity Improper form when lifting Tobacco use Sciatica symptoms Penn Medicine further reports sciatica pain can vary from mild tingling to a dull ache or a burning sensation. Typically, the pain affects one side of the body. It may worsen: After standing or sitting At night When sneezing, coughing or laughing When bending backwards or walking a few yards When straining or holding your…  read on >  read on >

Summer’s here and the Mayo Clinic says babies need protection from the sun’s damaging UV rays, too. It only takes one severe sunburn during childhood or adolescence to nearly double the risk for a deadly melanoma later in life, according to the American Academy of Dermatology Association. Babies are far more vulnerable to sunburn than older kids, so it’s essential to protect them against UV rays, said pediatric dermatologist Dr. Megha Tollefson, who offers tips for keeping babies safe outdoors. “Sunburns can be very painful,” she said, adding that severe sunburn can be a setup for infection. Sunburns are usually short-term concerns, but they pose long-term risks, too. “The more UV exposure a child gets — especially the younger in life that it starts — and the more sunburns they have, the higher their risk for skin cancer later in life,” said Tollefson, who practices in Rochester, Minn. Protecting yourself from the sun during the first 20 years of life is crucial for guarding against the long-term risk of skin cancer. For infants, avoid peak sun hours from 10 a.m. to 4 p.m. If that’s not possible, cover the baby with shade or long-sleeved clothing and a hat. Tollefson also recommends using sunscreen on areas of exposed skin. “We would recommend that, at that age, parents use the sunscreens that have physical blockers rather than…  read on >  read on >