The benefits of psilocybin treatment for depression might last as long as five years for some, a new study says. Two-thirds of participants in an early psilocybin clinical trial remained in complete remission from their depression when researchers checked in on them five years later, according to results published in the Journal of Psychedelic Studies. “Five years later, most people continued to view this treatment as safe, meaningful, important and something that catalyzed an ongoing betterment of their life,” said lead researcher Alan Davis, director of the Center for Psychedelic Drug Research and Education at Ohio State University in Columbus. “It’s important for us to understand the details of what comes after treatment,” he said in a news release. “I think this is a sign that regardless of what the outcomes are, their lives were improved because they participated in something like this.” Psilocybin is the main psychedelic substance found in magic mushrooms. Research has shown that psilocybin could potentially be effective in treating alcoholism, anxiety and depression, according to the National Center for Complementary and Integrative Health.  In the original clinical trial, 24 people with major depressive disorder received two doses of psilocybin combined with psychotherapy. Overall, the participants experienced a significant reduction in their depression symptoms. Of those participants, 18 agreed to the five-year follow-up, in which they filled out a series of…  read on >  read on >

Everyone gets headaches, but not all headaches are the same.  For some, they’re a quick inconvenience. For others, they can be intense, long-lasting and even disabling, disrupting daily life for days or weeks. Experts say finding the right treatment depends on identifying the type of headache and understanding what triggers it. “We define chronic headache as having more than 15 headache days per month. So, more days with headache than not,” Michael Oshinsky, a pain expert at the National Institutes of Health (NIH), told its monthly newsletter News In Health. The most common kind is a tension-type headache, often linked to stress, lack of sleep, dehydration or poor posture. Pain usually feels mild to moderate and affects both sides of the head. Migraines are another frequent cause of disabling pain. Unlike tension headaches, migraines are a complex brain condition that can cause: Severe pain on one or both sides of the head Nausea or vomiting Sensitivity to light, noise and smells Fatigue and mood changes “Migraine is a disorder where the ‘volume knob’ of the nervous system has been turned up,” said Dr. K.C. Brennan, a migraine researcher at the University of Utah in Salt Lake City. Other headache types include: Cluster headaches: Sudden, severe pain that often occurs in cycles Post-traumatic headaches: Common after concussions or head injuries Secondary headaches: Caused by underlying issues…  read on >  read on >

Everyone gets headaches, but not all headaches are the same.  For some, they’re a quick inconvenience. For others, they can be intense, long-lasting and even disabling, disrupting daily life for days or weeks. Experts say finding the right treatment depends on identifying the type of headache and understanding what triggers it. “We define chronic headache as having more than 15 headache days per month. So, more days with headache than not,” Michael Oshinsky, a pain expert at the National Institutes of Health (NIH), told its monthly newsletter News In Health. The most common kind is a tension-type headache, often linked to stress, lack of sleep, dehydration or poor posture. Pain usually feels mild to moderate and affects both sides of the head. Migraines are another frequent cause of disabling pain. Unlike tension headaches, migraines are a complex brain condition that can cause: Severe pain on one or both sides of the head Nausea or vomiting Sensitivity to light, noise and smells Fatigue and mood changes “Migraine is a disorder where the ‘volume knob’ of the nervous system has been turned up,” said Dr. K.C. Brennan, a migraine researcher at the University of Utah in Salt Lake City. Other headache types include: Cluster headaches: Sudden, severe pain that often occurs in cycles Post-traumatic headaches: Common after concussions or head injuries Secondary headaches: Caused by underlying issues…  read on >  read on >

A new type of noninvasive brain stimulation may help people with moderate to severe depression feel better faster than standard treatments, researchers in a new report say. The method, called high-definition transcranial direct current stimulation (HD-tDCS), uses small electrodes on the scalp to deliver mild electrical currents to specific parts of the brain involved in mood regulation. In the trial conducted by UCLA researchers, 71 adults with major depression were randomly assigned to receive either active HD-tDCS or a sham treatment for 20 minutes a day over 12 working days.  The group receiving real treatment showed a greater drop in their depression scores than the control group, according to findings published Sept. 11 in JAMA Network Open. On average, depression scores fell by nearly eight points in the active group compared to about six points in the sham group.  Patients who received HD-tDCS were also more likely to reach remission, with 39.5% reporting very low symptoms versus 13.3% in the sham group, the study noted. “By honing in on the precise brain regions affected by depression, we’ve shown that stimulation can significantly improve mood and daily functioning,” lead author Mayank Jog, an assistant professor of neurology at UCLA, said in a news release. The therapy was safe and well-tolerated, with only mild side effects such as skin redness or a burning sensation.  Importantly, mood improvements…  read on >  read on >

A new type of noninvasive brain stimulation may help people with moderate to severe depression feel better faster than standard treatments, researchers in a new report say. The method, called high-definition transcranial direct current stimulation (HD-tDCS), uses small electrodes on the scalp to deliver mild electrical currents to specific parts of the brain involved in mood regulation. In the trial conducted by UCLA researchers, 71 adults with major depression were randomly assigned to receive either active HD-tDCS or a sham treatment for 20 minutes a day over 12 working days.  The group receiving real treatment showed a greater drop in their depression scores than the control group, according to findings published Sept. 11 in JAMA Network Open. On average, depression scores fell by nearly eight points in the active group compared to about six points in the sham group.  Patients who received HD-tDCS were also more likely to reach remission, with 39.5% reporting very low symptoms versus 13.3% in the sham group, the study noted. “By honing in on the precise brain regions affected by depression, we’ve shown that stimulation can significantly improve mood and daily functioning,” lead author Mayank Jog, an assistant professor of neurology at UCLA, said in a news release. The therapy was safe and well-tolerated, with only mild side effects such as skin redness or a burning sensation.  Importantly, mood improvements…  read on >  read on >

Destroying the Amazon rainforest doesn’t just threaten the environment, it may also make people sick. A study published Sept. 11 in the journal Communications Earth & Environment found that rates of certain diseases were lower in regions where forests were protected and managed by Indigenous peoples.  Researchers say the findings add evidence to what Indigenous communities have long believed: That human health and the health of the forest are deeply connected. “The ‘forest man’ or ‘man forest,’ according to the Indigenous perspective, has always been linked to the reciprocity between human health and the natural environment where one lives,” Francisco Hernández Cayetano, president of the Federation of Ticuna and Yagua Communities of the Lower Amazon (FECOTYBA) in Peru, told The Associated Press. “If each state does not guarantee the rights and territories of Indigenous peoples, we would inevitably be harming their health, their lives and the ecosystem itself,” he added. For the study, researchers examined forest quality, legal recognition of Indigenous territories and disease rates across Amazon countries. They found that healthier forests often resulted in fewer cases of respiratory illness and infectious diseases like malaria. “They claim that Indigenous territories only protect health when forest cover is above 40%. And so that that feels like, why 40%? Why not 35? Or why not a range?” said Magdalena Hurtado, a professor of anthropology and global…  read on >  read on >

Destroying the Amazon rainforest doesn’t just threaten the environment, it may also make people sick. A study published Sept. 11 in the journal Communications Earth & Environment found that rates of certain diseases were lower in regions where forests were protected and managed by Indigenous peoples.  Researchers say the findings add evidence to what Indigenous communities have long believed: That human health and the health of the forest are deeply connected. “The ‘forest man’ or ‘man forest,’ according to the Indigenous perspective, has always been linked to the reciprocity between human health and the natural environment where one lives,” Francisco Hernández Cayetano, president of the Federation of Ticuna and Yagua Communities of the Lower Amazon (FECOTYBA) in Peru, told The Associated Press. “If each state does not guarantee the rights and territories of Indigenous peoples, we would inevitably be harming their health, their lives and the ecosystem itself,” he added. For the study, researchers examined forest quality, legal recognition of Indigenous territories and disease rates across Amazon countries. They found that healthier forests often resulted in fewer cases of respiratory illness and infectious diseases like malaria. “They claim that Indigenous territories only protect health when forest cover is above 40%. And so that that feels like, why 40%? Why not 35? Or why not a range?” said Magdalena Hurtado, a professor of anthropology and global…  read on >  read on >

A “keto” diet might help people with depression, a small-scale pilot study suggests. Depression symptoms decreased by about 70% among a small group of college students who followed a ketogenic diet for at least 10 weeks, researchers reported in the journal Translational Psychiatry. “So many people are suffering right now, so it’s rewarding to potentially bring forward a solution,” said lead researcher Jeff Volek, a professor of human sciences at Ohio State University in Columbus. “There is more science yet to do, but because there is evidence of a benefit, expanding accessibility to a well-formulated ketogenic diet as an augmentation to treatment for depression is something to think about,” he said in a news release. Ketogenic diets focus on replacing carbohydrates with fats, so that the body starts burning fats for fuel rather than blood sugar, according to the Cleveland Clinic. Ketones are the energy-providing acids released by fats that the body and brain start using as fuel as an alternative to glucose, researchers said. When the body has adapted to using ketones, it is said to have entered a state of nutritional ketosis. For the new study, 24 college students with diagnosed depression were asked to adopt a keto diet. Of those, 16 completed the entire study. In the diet, they were asked to consume fewer than 50 grams of carbs per day, combined…  read on >  read on >

A “keto” diet might help people with depression, a small-scale pilot study suggests. Depression symptoms decreased by about 70% among a small group of college students who followed a ketogenic diet for at least 10 weeks, researchers reported in the journal Translational Psychiatry. “So many people are suffering right now, so it’s rewarding to potentially bring forward a solution,” said lead researcher Jeff Volek, a professor of human sciences at Ohio State University in Columbus. “There is more science yet to do, but because there is evidence of a benefit, expanding accessibility to a well-formulated ketogenic diet as an augmentation to treatment for depression is something to think about,” he said in a news release. Ketogenic diets focus on replacing carbohydrates with fats, so that the body starts burning fats for fuel rather than blood sugar, according to the Cleveland Clinic. Ketones are the energy-providing acids released by fats that the body and brain start using as fuel as an alternative to glucose, researchers said. When the body has adapted to using ketones, it is said to have entered a state of nutritional ketosis. For the new study, 24 college students with diagnosed depression were asked to adopt a keto diet. Of those, 16 completed the entire study. In the diet, they were asked to consume fewer than 50 grams of carbs per day, combined…  read on >  read on >

County jail inmates who receive medication to treat their opioid addiction have a lower risk of overdose after their release, a new study reports. They’re also significantly more likely to continue their addiction treatment, researchers reported Sept. 10 in The New England Journal of Medicine. “These findings demonstrate the importance of providing medications to treat opioid use disorder in correctional settings,” Dr. Nora Volkow, director of the National Institute on Drug Abuse, said in a news release. “Offering effective opioid treatment to people in jail is a critical step toward addressing the opioid crisis, promoting recovery, saving lives and reducing reincarceration,” added Volkow, whose agency funded the research. “It’s a win-win for public health.” The opioid epidemic contributed to more than 80,000 deaths in 2024, and there tends to be a higher proportion of people with opioid abuse disorder in jail compared to the general population, researchers said in background notes. Medications like buprenorphine, methadone and naltrexone are known to be effective in helping people break their opioid addiction, but they are available in only about 13% of U.S. jails, researchers said. For this study, researchers analyzed data from 6,400 people with probable opioid use disorder incarcerated in seven Massachusetts county jails between September 2019 and December 2020. In 2018, Massachusetts passed a law enacting a four-year pilot program to provide opioid addiction medications to…  read on >  read on >