All Sauce from Weekly Gravy:

Standardized tests put a lot of pressure on teenagers who want to secure their future and make their parents and teachers proud. This stress can lead to symptoms like stomach aches, sleep problems, irritability and heightened emotionality, experts say. But there are concrete steps students can take to prepare for a standardized test while also keeping their cool. Live healthy. Getting enough sleep, eating healthy without skipping meals and engaging in some physical activity are all healthy lifestyle habits that help reduce stress, said Eric Storch, vice chair of psychology at Baylor College of Medicine in Houston. “A lot of people end up thinking they need to spend more time studying or don’t have time for exercise or meals, but it ends up turning into a vicious cycle of not taking care of yourself, which contributes to worse future performance,” Storch said in a Baylor news release. Schedule breaks. Make sure breaks to relax and unwind are included in a study schedule. Manage expectations. A sense of perspective about these tests is important. Students shouldn’t think about them in black-and-white terms of total success or utter failure. “Reflect on if the world will end if you don’t get a perfect score. Maybe you didn’t do as well as you wanted on that test, but you didn’t fail,” Storch said. Talking with a friend or parent…  read on >  read on >

Intense weather fluctuations caused by climate change could be contributing to an increase in stroke deaths, a new study claims. Freezing cold fronts and broiling heat waves are associated with more than half a million deaths annually in recent years, researchers report April 10 in the journal Neurology. “Dramatic temperature changes in recent years have affected human health and caused widespread concern,” said researcher Quan Cheng, of Xiangya Hospital at Central South University in Changsha, China. “Our study found that these changing temperatures may increase the burden of stroke worldwide, especially in older populations and areas with more health care disparities,” Cheng added in a journal news release. Bone-chilling cold fronts in particular were linked to more strokes, researchers said. But temperatures that swing too high or too low can both increase a person’s risk of stroke, researchers added in background notes. Lower temperatures cause a person’s blood vessels to constrict, increasing blood pressure. High blood pressure is a primary risk factor for stroke. On the other hand, higher temperatures can cause dehydration, which thickens and slows blood — factors also associated with stroke. Stroke deaths in the United States increased 26% between 2011 and 2021, according to the American Heart Association. Some of this could be tied to climate change, the researchers argue. For the study, the team looked at three decades of health…  read on >  read on >

Toddlers who grow up near nature are less likely to have emotional issues, even if the green space is just a park or a big back yard, a new study shows. The more green space there is within three-fourths of a mile from a child’s home, the fewer symptoms of anxiety and depression they’ll have between the ages of 2 and 5, investigators found. “Our research supports existing evidence that being in nature is good for kids,” said researcher Nissa Towe-Goodman, with the Frank Porter Graham Child Development Institute at the University of North Carolina. “It also suggests that the early childhood years are a crucial time for exposure to green spaces.” For the study, researchers examined data from more than 2,100 children in 199 counties across 41 U.S. states.  The team compared the depression and anxiety symptoms of the children — who ranged in age from 2 to 11 — to satellite data about the green space located near their homes. More green space was significantly associated with less anxiety and depression among younger kids, even after accounting for other factors, researchers said. Those other factors included the child’s gender, parent education and the social and economic quality of their neighborhood. However, researchers found no significant link between green space and mental health symptoms from ages 6 to 11, after kids have started school.…  read on >  read on >

The discovery of a gene variant that rids the brain of toxic plaques linked to Alzheimer’s might lead to new treatments for the disease, researchers report. The variant arises naturally in people who don’t seem to get Alzheimer’s disease despite having another gene, called APOEe4, that strongly promotes the illness. “These resilient people can tell us a lot about the disease and what genetic and non-genetic factors might provide protection,” explained study co-lead author Badri Vardarajan, an assistant professor of neurological science at Columbia University in New York City. “We hypothesized that these resilient people may have genetic variants that protect them from APOEe4,” Vardarajan added in a university news release. The researchers believe the newly discovered gene variant may reduce the risk for Alzheimer’s by more than 70% in folks lucky enough to carry it. Breaking the blood-brain barrier In their research, Vardarajan and colleagues conducted genomic screening on hundreds of individuals who carried the APOEe4 gene variant, which greatly raises the risk for Alzheimer’s, but who had gone into old age without developing the disease. The found a common variant shared by many of these people. It occurred in a gene charged with making fibronectin, a component used to make the “blood-brain barrier.” That’s the lining that surrounds the brain and helps police which substances can get in and out. People who develop Alzheimer’s tend…  read on >  read on >

More middle-aged Black and Native Americans are now falling prey to “deaths of despair” than whites, a new study finds. These deaths — from suicide, drug overdose and alcoholic liver disease — initially had been more common among whites. But a new analysis has determined that deaths of despair have skyrocketed for Black and Native Americans over the past decade. The deaths of despair rate among Black Americans tripled between 2013 and 2022, rising from 36 deaths per 100,000 people to nearly 104 deaths per 100,000, researchers found. That’s slightly higher than the 2022 rate among white Americans, which was nearly 103 deaths per 100,000. The rate is worst among Native American/Alaska Native people, who suffered nearly 242 deaths of despair per 100,000 in 2022. “The findings reinforce the notion that we need to invest in services that can address these issues and, ultimately, we need much more comprehensive access to low-barrier mental health care and substance use treatment in the U.S.,” said researcher Joseph Friedman, of the David Geffen School of Medicine at UCLA. “And we need to specifically make sure those treatments, services and programs are implemented in a way that is accessible for communities of color and will actively work to address inequality,” Friedman added in a university news release. Deaths of despair attained the spotlight following a 2015 study that analyzed…  read on >  read on >

Phillips Respironics, the company responsible for the recall of millions of defective sleep apnea machines since 2021, must overhaul its production of the machines before it can resume making them in the United States, federal officials announced Tuesday. Under a settlement reached with the company, Phillips must revamp its manufacturing and quality control systems and hire independent experts to vet the changes. Phillips must also continue to replace, repair or provide refunds to all U.S. customers who got defective devices, the court order stated. The action helps resolve one of the biggest medical device recalls in history, which has dragged on for nearly three years and involved 15 million devices worldwide, the U.S. Food and Drug Administration said. “The finalization of this decree is a significant milestone. Throughout this recall, we have provided patients with important health information by issuing numerous safety communications and have taken actions rarely used by the agency to help protect those impacted by this recall,” Dr. Jeff Shuren, director of the FDA’s Center for Devices and Radiological Health, said in an agency news release. “Today’s action is a culmination of those efforts and includes novel provisions aimed at helping ensure that patients receive the relief they have long deserved.” Most of the devices that have been recalled are continuous positive airway pressure (CPAP) machines. These devices force air through a…  read on >  read on >

The Environmental Protection Agency announced Wednesday that it has finalized a first-ever rule that will drastically lower the amount of PFAS, also known as “forever chemicals,” in the nation’s drinking water. “Drinking water contaminated with PFAS has plagued communities across this country for too long,” EPA Administrator Michael Regan said in an agency news release announcing the new rule. “That is why President Biden has made tackling PFAS a top priority, investing historic resources to address these harmful chemicals and protect communities nationwide.” Exposure to PFAS has been linked to various cancers, liver and heart issues, and immune and developmental damage to infants and children, the agency noted. The level of exposure is significant in the United States: A 2023 government study detected PFAS in nearly half of the country’s tap water. The new rule, which requires utilities to reduce PFAS to the lowest level they can reliably be measured, should lower PFAS exposure for approximately 100 million people, the agency noted. In addition to the new rule, the EPA also announced that nearly $1 billion in new funding should help states and territories implement PFAS testing and treatment at public water systems and help owners of private wells address PFAS contamination. While environmental experts and health advocates welcomed the news, water utilities warned the new rule will cost billions more than the EPA has estimated and fall hardest on…  read on >  read on >

Early-onset arthritis may hit as many as one in every four young people who undergo anterior cruciate ligament (ACL) reconstruction surgeries, new research warns. The arthritic pain emerges within 6 to 12 months post-surgery, according to Michigan State University (MSU) researchers. Many of these cases occur in people under 40 and go unrecognized and untreated. “We’re trying to change the narrative,” said study lead author Matthew Harkey, an assistant professor of kinesiology at MSU. “We see fairly young, active individuals experiencing extensive symptoms, but these symptoms are not interpreted by clinicians as something that may be related to osteoarthritis. Ignoring these symptoms might be setting them up to experience long-term decline and function.” Tears to the ACL ligament within the knee are common, and often corrected with a surgery that replaces the ligament with a graft. Over 400,000 ACL reconstructions are performed in the United States annually, according to the National Institutes of Health. In the new study, Harkey’s team examined outcomes for 82 people, ages 13 to 35, who underwent ACL reconstructive surgeries. Almost a quarter of the patients reported “persistent early arthritis symptoms from 6 to 12 months after knee surgery,” according to a university news release. In another Harkey-led study, data from 3,200 individuals supplied by the New Zealand ACL Registry showed that almost a third of patients developed arthritic pain within…  read on >  read on >

Wegovy, Ozempic and other drugs known as GLP-1 analogues have become wildly popular for controlling diabetes and helping folks lose weight. There were concerns that longer term use of the drugs might raise users’ odds for thyroid cancer, but a Swedish study of more than 435,000 people finds no evidence to support that notion. “Many people take these medicines, so it is important to study potential risks associated with them,” said study lead author Björn Pasternak. He’s principal researcher at the department of medicine at the Karolinska Institute in Stockholm. “Our study covers a broad group of patients and provides strong support that GLP-1 analogues are not associated with an increased risk of thyroid cancer,” he said in an institute news release. The findings were published April 9 in the BMJ. In the analysis, Pasternak’s team used data from a major Scandinavian database involving 145,000 people who were taking GLP-1 analogues such as liraglutide (Victoza) or semaglutide (Ozempic), and 290,000 people who were taking one of another class of diabetes drugs called DPP4 inhibitors. The study found no higher odds for thyroid cancer among folks taking GLP-1 analogues compared to those on DPP4 inhibitors. That finding was repeated when GLP-1 analogue users were compared to patients taking a third class of diabetes meds, called SGLT2 inhibitors. Study co-author Peter Ueda, an assistant professor of medicine…  read on >  read on >

A new drug can slash triglyceride levels nearly in half by targeting a genetic driver of high fat levels in the bloodstream, researchers said. The injectable drug, olezarsen, lowered triglyceride levels by 49% at the 50 milligram (mg) dose and by 53% at the 80 mg dose compared to a placebo, researchers reported April 7 in the New England Journal of Medicine. The findings were presented simultaneously at the American College of Cardiology’s annual meeting in Atlanta. The drug also reduced blood levels of two other contributors to clogged arteries, apolopoprotein B and “bad” cholesterol, results show. Olezarsen inhibits the activity of APOC3, a gene that typically restrains the liver’s ability to filter triglycerides out of the bloodstream, the researchers said. “These findings indicate that targeting APOC3 is a promising new pathway for lowering triglycerides and potentially reducing the risk of heart attack and stroke,” said researcher Dr. Brian Bergmark, of the Brigham and Women’s Hospital Division of Cardiovascular Medicine. Triglycerides are fatty particles in the bloodstream that contribute to the risk of heart disease, both on their own and in combination with “bad” LDL cholesterol, according to Harvard Medical School. For the study, researchers recruited 154 adults already on cholesterol-lowering therapy. They were split into three groups and assigned to either take a placebo or a low or high dose of olezarsen, through injections…  read on >  read on >