All Sauce from Weekly Gravy:

A Texas federal judge has issued a preliminary ruling that invalidates the U.S. Food and Drug Administration approval in 2000 of mifepristone, the first of two drugs most commonly taken during a medical abortion. Judge Matthew Kacsmaryk added a seven-day stay to his order, issued Friday, to give the FDA time to mount an appeal. About an hour later, Washington state federal judge Thomas Rice issued a countering decision in a case filed there, ordering a halt to “any action to remove mifepristone from the market or otherwise cause the drug to become less available.” The two opposing rulings would suggest that any final decision on the availability of mifepristone, which is typically given alongside misoprostol to cause an abortion, may end up at the Supreme Court. The Washington state lawsuit originated with Democratic attorneys general who were challenging restrictions in place that made it difficult to obtain mifepristone. The Texas decision involves a lawsuit filed by a coalition made up of doctors and anti-abortion groups who sought an end to the use of mifepristone, claiming that the FDA’s decision 23 years ago to approve the drug was made hastily and without proper regard for its overall safety. In his decision, Kacsmaryk said that, ”The court does not second-guess [the] FDA’s decision-making lightly. But here, FDA acquiesced on its legitimate safety concerns — in violation…  read on >  read on >

Put out that cigarette for the health of your four-legged friend. When smokers search social media for anti-tobacco information, they tend to engage most with posts about the risk of secondhand smoke on their pets, a new study reveals. Posts with new information about harmful chemicals also receive high engagement, researchers found. “Our results show that people respond to messaging on how smoking negatively affects the lives of those they care about, including pets. Messages that are personally meaningful to smokers can help to generate positive behavioral changes among smokers,” said principal investigator Hong Xue, an associate professor of health administration at George Mason University in Fairfax, Va. “Anti-tobacco campaigns can use these findings to improve their campaigns, better engage the public, and more effectively promote reasons to stop smoking,” he said in a university news release. The researchers used machine learning and social media data to analyze factors that influence effective anti-smoking campaigns and user engagement. The study was led by Xue and GMU associate professor Gilbert Gimm. They described their work as the first large-scale social media data mining study that examined key anti-tobacco campaigns in the United States. Their research also found that large campaigns from government and nonprofit organizations had greater user engagement than smaller and local campaigns. Facebook users were much more likely to engage in messages with videos. About…  read on >  read on >

Dangerously low blood pressure is considered an “invisible” consequence of paralysis, adding to the woes of as many as 9 out of 10 people with spinal cord injuries. Now, a new implant has been developed that treats the problem by delivering electrical stimulation to a select group of spinal neurons. The device, called a neuroprosthetic baroflex, stimulates the lower part of the spine, which contains the most neurons involved in blood pressure control, researchers said. The findings were published April 6 as an essay in Science. Spinal cord injury often interferes with the brain’s ability to modulate blood pressure when a person changes posture, such as moving from a sitting to a standing position. This ability, called the baroreceptor reflex, involves a series of quick responses within the body to keep blood pressure in a normal range when someone abruptly changes position, the Cleveland Clinic says. The brain senses that artery walls are stretching due to a sudden increase in blood pressure. In response, the brain can order the body to compensate, though a series of reactions that take place within a couple of heartbeats. A person with a spinal cord injury can be rendered dizzy, nauseous or prone to fainting if their baroreceptor reflex fails and their blood pressure drops to very low levels as a result of trying to move. “Almost all of…  read on >  read on >

You may be struggling with stomach pain and digestive distress without understanding why, thinking it might be something you ate. Can stress cause stomach pain? Stress, especially chronic stress, can indeed increase your risk for gastrointestinal (GI) problems. “Stress and anxiety are common causes of stomach pain and other GI symptoms,” Dr. Nina Gupta, a gastroenterologist at University of Chicago Medicine, said recently in an article. Stress impacts the digestive system through the nervous system, and can affect food movement and the gut’s bacterial balance. Stress can also cause people to eat poorly, smoke and/or drink too much alcohol or caffeine — all habits that can trigger stomach pain. Outside the brain, the gut has the greatest area of nerves. This component of the autonomic nervous system — known as the enteric nervous system — is sometimes referred to as the “second brain.” According to Harvard Health, “neurons lining the digestive tract signal muscle cells to initiate a series of contractions that propel food farther along, breaking it down into nutrients and waste.” The enteric nervous system communicates with the central nervous system and is known as the “brain-gut axis.” This connection explains why stress may cause digestive problems. According to the American Psychological Association, stress may increase the risk for or exacerbate symptoms of the following gut diseases or dysfunction: Bloating, burping, gas Heartburn,…  read on >  read on >

For what they say is the first time, British researchers report that they have found the spread of COVID-19 in households is linked to the presence of the virus on hands and surfaces, not just in the air. The investigators collected data from households at the height of the pandemic, finding that people were much more likely to get COVID-19 from someone in their house if virus was present on hands or frequently touched places, like refrigerator door handles or sink faucets. “There’s no doubt that if you have COVID-19, you’re emitting the virus into the air as micro-aerosols as well as large droplets that land on your hands and the surfaces around you. What hasn’t been shown, until now, is that the presence of the virus on people’s hands or household surfaces predicts transmission to contacts,” said study author Ajit Lalvani. He is director of the National Institute of Health and Care Research (NIHR) Health Protection Research Unit (HPRU) in Respiratory Infections. The NIHR HPRU is a research partnership between Imperial College London and the UK Health Security Agency. Researchers from University of Oxford also worked on the study. “Our real-life study in London households provides the first empirical evidence to show that the presence of SARS-CoV-2 on people’s hands and surfaces contributes significantly to spread of COVID-19. Since we didn’t systematically sample household…  read on >  read on >

Four out of 10 people who have lingering health issues after COVID-19 infection can count bothersome sleep problems among them. About 41% of those with so-called long COVID have moderate to severe sleep issues, according to new research from the Cleveland Clinic in Ohio. Black patients are three times more likely to develop these sleep disturbances. “Sleep difficulties and fatigue are widely reported by people with long COVID, but little is known about the severity and factors associated with these symptoms,” said lead author Dr. Cinthya Pena Orbea, assistant professor of medicine at Cleveland Clinic’s Sleep Disorders Center. “Our findings not only emphasize the importance of identification of sleep disturbance in long COVID considering its impact on patients’ quality of life, daytime functioning and medical health status, but they also draw the attention to the persistent inequities seen throughout the COVID-19 pandemic,” Pena Orbea said in a clinic news release. Risk factors for these lingering sleep disturbances include race, hospitalization for COVID-19, and greater severity of anxiety and fatigue, she and her colleagues found. The researchers analyzed data collected from 962 long-COVID patients who were treated at Cleveland Clinic’s reCOVer Clinic between February 2021 and April 2022. The patients, all adults, completed sleep disturbance and fatigue questionnaires. Among the other findings: About 67% reported moderate to severe fatigue. About 22% reported severe fatigue. More than…  read on >  read on >

The U.S. Food and Drug Administration on Thursday formally withdrew its approval of a drug that was meant to prevent preterm births. Sold as Makena, the drug was first approved in 2011 under the FDA’s accelerated approval program, but subsequent research questioned the medication’s effectiveness and noted serious side effects that included blood clots and depression. “It is tragic that the scientific research and medical communities have not yet found a treatment shown to be effective in preventing preterm birth and improving neonatal outcomes — particularly in light of the fact that this serious condition has a disparate impact on communities of color, especially Black women,” FDA Commissioner Dr. Robert Califf said in an agency news release. “Fundamentally, however, the touchstone of FDA drug approval is a favorable benefit-risk assessment; without that favorable assessment, the drug should not have the status of being FDA-approved,” Califf added. The decision follows a meeting of one of the agency’s advisory committees last October where panel members voted 14-1 to recommend that Makena be pulled from the market. FDA officials have long said they want to withdraw the medication because of lack of evidence that it works and its side effects. “It would be unfair to keep the drug on the market and expose especially vulnerable populations to an ineffective therapy,” panel member Dr. Mark Hudak, a pediatrician at…  read on >  read on >

Does it sometimes feel like your young picky eater is turning every meal and snack into an epic power battle — and you’re just not sure how to get them the nutrition they need? If so, you’re not alone. According to an article published recently in the journal Pediatrics, up to 50% of kids may be described as “picky eaters.” And while there’s no one agreed-upon definition of picky eating, in general, if your child or adolescent is particular about the food they eat at least some of the time, you may have a picky eater on your hands. “I think all parents have said at one time, ‘My kid is such a picky eater!’” clinical psychologist Rachel Busman said in a recent Child Mind Institute article. “It’s very normal for kids to go through stages where they’re a little more picky, especially when they are trying to assert their autonomy.” Experts at the institute note that picky eating is one of the most “common complaints” of parents. Here, they and other child experts weigh in on the topic with five top tips for parents of picky eaters: Grocery shop and cook together Involving your child in grocery shopping can help extend their picky eater food list to include novel items, Busman explained. When they are shown a wide variety of food flavors and options,…  read on >  read on >

It’s well known that being overweight or obese can increase health risks. But a new study finds that the reasons why a person is obese may have some impact on heart disease risk. Specifically, being obese because of lifestyle carried higher risks than it did if the extra weight was due to genetic predisposition, researchers found. “The link between obesity and cardiovascular disease was twice as strong in those with a genetic predisposition to a low BMI as it was in those with obesity driven by genetic factors,” said study author Ida Karlsson, an assistant professor at the Department of Medical Epidemiology and Biostatistics at the Karolinska Institute in Solna, Sweden. To study this, her team used data from more than 15,000 twins from the Swedish Twin Registry. Information included their BMI and their genetic predisposition for high BMI. The researchers also used data from medical registries to establish the incidence of heart disease in this group. Karlsson stressed that a healthy lifestyle is always important for everyone. The risk of heart disease was still higher in all people who were overweight or obese compared to people with a healthy weight. “Obesity is a complex common disease that can have many different causes,” Karlsson said in an institute news release. “Since it’s so stigmatized, the results can help us understand that its effects on health…  read on >  read on >

Medicaid reimbursement for mental health services varies widely across the United States, making it hard for many folks who need help to get it, a new study finds. Researchers found as much as a fivefold difference among states in Medicaid reimbursement rates. Even though Medicaid, the governmental health care program for low-income Americans, serves a population that is disproportionately affected by mental illness, many providers choose not to care for Medicaid patients due to low reimbursement rates. At the same time, a growing demand for help with depression, anxiety and substance use means many psychologists are unable to take on new patients, according to a 2022 American Psychological Association survey. Medicare, the federal health insurance program for American seniors, pays much more for mental health services, the study found. “We find that Medicaid reimbursement to psychiatrists for a common set of 20 frequently billed services varies across states and that on average, Medicaid pays about 80% of what Medicare pays for the same services,” said lead researcher Dr. Jane Zhu, an assistant professor of medicine at Oregon Health & Science University. Mental health services generally have low insurance acceptance rates, but this is worse in Medicaid, partly due to low reimbursement rates, she said. “Our study confirms that some states are setting these reimbursement rates quite low, which has implications not just for provider acceptance…  read on >  read on >