All Sauce from Weekly Gravy:

Research in rats and hibernating squirrels has pinpointed a naturally occurring protein that appears to reverse cataracts, scientists report. Animal studies don’t always pan out in people, of course. But the discovery of the RNF114 protein raises the possibility of surgery-free cataract removal, according to a team from the U.S. National Eye Institute (NEI). “Understanding the molecular drivers of this reversible cataract phenomenon might point us in a direction toward a potential treatment strategy,” said the study’s co-lead investigator, Wei Li. He’s a senior investigator in the NEI’s Retinal Neurophysiology Section. His team published its findings Sept. 17 in the Journal of Clinical Investigation. As the NEI explained, “a cataract is a cloudy area in the lens of your eye [the clear part of the eye that helps to focus light]. This can make your vision cloudy.” Right now, surgery is a patient’s only treatment option, and almost 4 million such procedures are conducted in the United States each year. A non-surgical approach has long been a holy grail of ophthalmological research. Meanwhile, anyone living in the American heartland has probably seen a 13-lined ground squirrel. These hardy creatures are perfect for cataract research, Li’s team explained, because their retinas contain light-sensitive photoreceptor cells that are mostly cones, not the “rods and cones” found in the human eye. Cones are especially tied to color vision. These prairie squirrels can also withstand…  read on >  read on >

Antidepressants have the potential to improve memory and thinking skills, a new study suggests. Some patients experienced a boost on brain tests after taking the SSRI antidepressant escitalopram (Lexapro), researchers report. The drug appeared to affect a serotonin receptor in the brain called the 5HT4 receptor, according to results published recently in the journal Biological Psychiatry. Serotonin is described as a “feel good” hormone, researchers said in background notes. Higher levels of serotonin in the brain contribute to a sense of well-being and have been shown to ease clinical depression. “It seems that the SSRI medication contributes to an improvement on cognitive function, at the same time as helping improve mood,” said lead investigator Vibeke Dam, a senior researcher in neurology and neurobiology with Copenhagen University Hospital in Denmark. “Our work ties the improvement in cognitive function to the specific 5HT4 receptor and suggest that direct serotonin 4 receptor stimulation may be an important pro-cognitive target to consider in optimizing outcomes of antidepressant treatment,” Dam added in a journal news release. “It also reinforces the idea that serotonin is crucial to mood improvement.” For the study, researchers scanned the brains of 90 depressed patients to measure 5HT4 receptor function in their brains. The patients also were tested for mood problems and cognitive abilities. Then the patients were given daily escitalopram (Lexapro) for eight weeks. At…  read on >  read on >

It’s that time of year when respiratory viruses start to circulate widely, but how can you tell the difference between the symptoms of a cold, the flu and COVID? Dr. William Brian Glenn, from Hackensack Meridian Medical Group in New Jersey, shares what you need to know to be ready for whatever virus comes your way this fall and winter. The challenge with cold, flu and COVID-19 is that the symptoms for each are similar, Glenn noted. A cold can show up as cough, sneezing, runny nose, sore throat and fatigue, while the flu can include all of those symptoms plus headache, fever, chills, body aches and fatigue. Meanwhile, COVID can present with cold and flu symptoms, along with a loss of taste or smell, diarrhea, nausea and vomiting, or shortness of breath, Glenn said. Cold symptoms tend to come on gradually, while flu symptoms come on suddenly. COVID symptoms take between two and 14 days after exposure to surface — and can progress to more severe symptoms in some people. Are some people more at risk of developing colds, flu and COVID-19 than others? The elderly, as well as children and adults with chronic conditions including diabetes, lung or kidney disease, metabolic disorders, heart disease and cancer are more susceptible to respiratory infections. Taking certain medicines that weaken the immune system can also put…  read on >  read on >

SATURDAY, Sept. 21, 2024 (Healthday News) — Workplace anxiety. Who hasn’t experienced it? However, if that anxiety is so strong that it hurts your performance or lingers for months, you might have a problem, one expert says. Dr. Asim Shah, executive vice chair in the Menninger Department of Psychiatry and Behavioral Sciences at Baylor Colege of Medicine in Houston, explains what can trigger workplace anxiety, how to manage it and when to seek professional help. “The goal is not to suffer and not let your anxiety affect work performance. About 60% of people experience workplace anxiety. It is common, which means you can do something about it,” Shah said. Workplace anxiety can be caused by surly co-workers, a demanding supervisor, small, annoying tasks or overwhelming major projects. If you have workplace anxiety, you might notice signs like: Feeling overly anxious or nervous Experiencing excessive sweating or trembling Obsessing about a task Having a lack of interest in your work “The anxiety becomes so overwhelming that you are unable to focus and concentrate,” Shah noted in a Baylor news release. “These feelings can impair your daily work functions.” If that continues for more than six months, Shah said it might be time to seek professional help. “Some employers might offer an employee assistance program where you can go for help. You can also start talking to…  read on >  read on >

A cavalry of sorts can come to the rescue of combat veterans suffering from post-traumatic stress disorder (PTSD), a new study says. Combat veterans who regularly care for horses experience an easing of their PTSD symptoms, as well as an overall improved mental outlook, researchers found. Focusing on a horse’s welfare can help a veteran shed the hypervigilance that often accompanies PTSD, explained researcher Andrea Quinn, assistant director of the Center for Psychological Services in the Rutgers Graduate School of Applied and Professional Psychology. “When I think about what our veterans with PTSD struggle with, the results make sense,” Quinn said in a Rutgers news release. At some point, seven out of 100 veterans will develop PTSD, researchers said in background notes. Veterans of Operation Enduring Freedom in Afghanistan have the highest rates of PTSD, with 29% experiencing it at some point, researchers noted. Veterans of Operation Iraqi Freedom in Iraq have a 21% rate of PTSD. For the study, published recently in the journal Frontiers in Psychiatry, researchers asked six combat veterans to participate in an eight-week horsemanship program. In 30-minute weekly sessions, veterans were instructed on basic horse safety and horse behavior, then asked to groom a horse and lead it around an arena. “In the study, the veterans had to perform tasks requiring them to be very much in the moment,” Quinn…  read on >  read on >

Heavy-duty endurance exercise can cause body fat levels to drop without any accompanying weight loss, a new small-scale study indicates. A group of eleven middle-aged men who cycled 710 miles in seven days lost only about 1% of their total weight, because they ate and drank enough to offset the calorie burn. But they lost over 9% of their overall body fat, including a nearly 15% reduction in levels of dangerous visceral fat crowding their vital organs. The cyclists also experienced a more than 20% reduction in total cholesterol and a nearly 40% reduction in triglyceride levels, as well as a substantial reductions in blood pressure. The results “support the importance of promoting a physically active lifestyle rather than caloric restriction in obesity prevention,” concluded the research team led by co-senior author Jean-Pierre Despres, a professor of kinesiology with University Laval in France. In other words, the study “provides evidence that humans were designed to be physically active rather than eat as little as possible,” researchers wrote. For the study, researchers recruited 11 recreational male cyclists ages 50 to 66 who could maintain an average pace of nearly 19 miles per hour over long distances. The men all hailed from the Quebec City metropolitan area in Canada. During seven consecutive days, the cyclists were sent once or twice on a 64-mile road loop on the…  read on >  read on >

Millions of women struggle with the discomfort and stress of urinary incontinence, and many turn to medications for help. Now, new research suggests that yoga and other exercise regimens might work just as well to control these bladder issues. Researchers at Stanford University report that 12 weeks of yoga practice cut incontinence episodes among participants by an average of 65% — about the equivalent of taking a drug.  “I would say that I think it’s a great idea to try it if you’re interested,” said study senior author Dr. Leslee Subak, chair of obstetrics and gynecology at Stanford Medicine. “It’s very low risk, and there’s potential for benefit, not only for incontinence but also for your general well-being.” Her team published their findings recently in the Annals of Internal Medicine. According to the researchers, half of middle-aged women, and up to 80% of women aged 80, experience urinary incontinence. “It takes away independence,” Subak said in a university news release. “My patients will say, ‘I can’t stay with my kids or grandkids because I’m afraid I’ll wet the bed, and I can’t talk about it; it’s too embarrassing.’” It can even prove dangerous. “Incontinence and overactive bladder are among the biggest risk factors for falls and fractures among older women,” Subak noted. “You’re rushing to the bathroom at night — with the lights off —…  read on >  read on >

Each year, an average of 174 U.S. kids under the age of 5 lose their lives over causes linked to nursery products. Many of these tragedies could be prevented, and the Consumer Product Safety Commission (CPSC) on Thursday issued a list of products deemed most hazardous. Leading the list by far: Any soft bedding added into cribs, bassinets and playpens. These products alone were part of the cause of 126 child deaths between 2019 and 2021, the CPSC said. Also implicated: Inclined infant “sleepers” and similar products, and infant carriers. Together, soft bedding, inclined sleepers and baby carriers were tied to three-quarters (76%) of deaths, the agency said. Many of these products are unnecessary as well as dangerous, said CPSC Chair Alex Hoehn-Saric. “Babies aren’t little adults. They don’t need pillows and blankets to feel comfortable and safe when they sleep,” Hoehn-Saric said in a CPSC news release. “The safest way for your baby to sleep is without blankets, pillows, or other items surrounding them. A firm flat surface in a crib, bassinet, play yard or bedside sleeper with just a fitted sheet is all they need.” Always put infants to bed on their backs, to cut the risk for sudden unexpected infant death syndrome (SIDS/SUID) and suffocation. If your baby falls asleep while in a swing, bouncer, lounger or similar product, transfer them to…  read on >  read on >

Doctors sometimes turn to antidepressants as a means of easing older people’s physical pain, but a new expert review finds there’s little evidence to support the practice. Antidepressants may even come with hazards for seniors who don’t need them, said researchers from the University of Sydney in Australia. “Harms of antidepressant use in older people are well documented,” said study senior author Dr. Christina Abdel Shaheed. Her team found that, compared to older folks using other methods to ease pain, those on antidepressants had higher risks for falling, dizziness and injury. “These medicines are being prescribed to remedy patients’ pain, despite the lack of evidence to adequately inform their use,” said Abdel Shaheed, an associate professor in the university’s School of Public Health and the Institute for Musculoskeletal Health. The findings were published recently in the British Journal of Clinical Pharmacology. According to the researchers, over the past 40 years there have been only 15 trials worldwide that focused on the use of antidepressants for physical pain in people over the age of 65. Poring over the data from these studies, the Sydney team found little evidence to support the use of the drugs to ease pain in seniors. Standard international guidelines do support the use of antidepressants for chronic pain generally, but the data those guidelines are based on did not focus on patients…  read on >  read on >

Would-be dads don’t have to worry that taking the epilepsy drug valproate will result in children with birth defects, a new review concludes. Valproate, an anti-seizure drug, is known to cause birth defects and developmental disorders when taken by pregnant women. But the drug does not appear to have the same impact on the fetus when taken by men hoping to become fathers, researchers report. “Our systematic review shows that evidence for any risk to the offspring resulting from paternal exposure to anti-seizure medications is scarce and inconsistent, with most studies showing no increased risk compared with unexposed controls,” wrote the research team led by co-senior author Piero Perucca, a professor of adult epilepsy with the University of Melbourne in Australia. “Therefore, the available evidence does not justify major concerns,” the team concluded. Experimental animal studies have linked anti-seizure drugs to male infertility, birth defects and developmental delays, sparking concerns that human males might run the same risks. In fact, one major government regulatory body — the U.K.’s Medicines and Healthcare Products Regulatory Agency — has gone so far as to prohibit valproate use for anyone under the age of 55 who might become a new parent. For the new review, researchers pooled data on 10 studies evaluating the effects on pregnancy of valproate taken by men. Although the data were limited, researchers found no…  read on >  read on >