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Research in rats and hibernating squirrels has pinpointed a naturally occurring protein that appears to reverse cataracts, scientists report. Animal studies don’t always pan out in people, of course. But the discovery of the RNF114 protein raises the possibility of surgery-free cataract removal, according to a team from the U.S. National Eye Institute (NEI). “Understanding the molecular drivers of this reversible cataract phenomenon might point us in a direction toward a potential treatment strategy,” said the study’s co-lead investigator, Wei Li. He’s a senior investigator in the NEI’s Retinal Neurophysiology Section. His team published its findings Sept. 17 in the Journal of Clinical Investigation. As the NEI explained, “a cataract is a cloudy area in the lens of your eye [the clear part of the eye that helps to focus light]. This can make your vision cloudy.” Right now, surgery is a patient’s only treatment option, and almost 4 million such procedures are conducted in the United States each year. A non-surgical approach has long been a holy grail of ophthalmological research. Meanwhile, anyone living in the American heartland has probably seen a 13-lined ground squirrel. These hardy creatures are perfect for cataract research, Li’s team explained, because their retinas contain light-sensitive photoreceptor cells that are mostly cones, not the “rods and cones” found in the human eye. Cones are especially tied to color vision. These prairie squirrels can also withstand… read on > read on >