All Sauce from Weekly Gravy:

Obesity shouldn’t be considered a barrier for a patient who needs shoulder replacement surgery, a new study argues. In some places, doctors have been denying joint replacement surgery to people with a high body-mass index, due to concerns over their ability to recover from the procedure, researchers said in background notes. But patients with obesity actually have a lower risk of death following the surgery than patients at a healthy weight, researchers reported Nov. 20 in the journal PLOS Medicine. They also had about the same risk of suffering serious complications or needing follow-up surgery, researchers found. In fact, underweight patients fared worst following shoulder replacement surgery, results show. “While BMI thresholds have been used to limit access to joint replacement surgery, our findings do not support restricting higher BMI patients from accessing shoulder replacement surgery,” senior researcher Dr. Jonathan Rees, director of the Botnar Institute for Musculoskeletal Sciences at the University of Oxford, said in a news release. Even though medical societies have offered no formal recommendations regarding a patient’s weight and joint replacement surgery, previous studies have found that in some countries access to these procedures is restricted based on BMI, researchers said in background notes. For this new study, researchers tracked nearly 21,000 patients who underwent shoulder replacement surgery in the United Kingdom and Denmark. Results showed that people with obesity had…  read on >  read on >

Obesity shouldn’t be considered a barrier for a patient who needs shoulder replacement surgery, a new study argues. In some places, doctors have been denying joint replacement surgery to people with a high body-mass index, due to concerns over their ability to recover from the procedure, researchers said in background notes. But patients with obesity actually have a lower risk of death following the surgery than patients at a healthy weight, researchers reported Nov. 20 in the journal PLOS Medicine. They also had about the same risk of suffering serious complications or needing follow-up surgery, researchers found. In fact, underweight patients fared worst following shoulder replacement surgery, results show. “While BMI thresholds have been used to limit access to joint replacement surgery, our findings do not support restricting higher BMI patients from accessing shoulder replacement surgery,” senior researcher Dr. Jonathan Rees, director of the Botnar Institute for Musculoskeletal Sciences at the University of Oxford, said in a news release. Even though medical societies have offered no formal recommendations regarding a patient’s weight and joint replacement surgery, previous studies have found that in some countries access to these procedures is restricted based on BMI, researchers said in background notes. For this new study, researchers tracked nearly 21,000 patients who underwent shoulder replacement surgery in the United Kingdom and Denmark. Results showed that people with obesity had…  read on >  read on >

Kissing may feel like a very human habit, but new research suggests it has much deeper roots. A team of scientists says the behavior likely began more than 20 million years ago, long before modern humans existed. Researchers from Oxford University in England reviewed decades of studies on primates to understand how kissing may have evolved. By comparing the behavior of living species such as chimpanzees, bonobos, orangutans and one gorilla species, the team used statistical modeling to estimate when kissing first appeared. Their results, published Nov. 19 in the journal Evolution and Human Behavior, suggest that an ancient ancestor of today’s apes likely engaged in mouth-to-mouth contact between 16.9 million and 21.5 million years ago. Kissing presents an “evolutionary conundrum,” study lead author Matilda Brindle, an evolutionary biologist at Oxford, said to CNN. She said the behavior is surprising because it carries some obvious risks, including spreading germs, and may not directly help with survival. Yet across primate species, kissing and similar behaviors may serve many purposes, Brindle said. These include: finding potential partners foreplay building social bonds soothing tension helping parents feed infants by chewing food first Because the behavior isn’t a fossil, researchers must study living species to better understand the past. The oldest written records of human kissing date back about 4,500 years to ancient Mesopotamia and Egypt. But kissing today…  read on >  read on >

Kissing may feel like a very human habit, but new research suggests it has much deeper roots. A team of scientists says the behavior likely began more than 20 million years ago, long before modern humans existed. Researchers from Oxford University in England reviewed decades of studies on primates to understand how kissing may have evolved. By comparing the behavior of living species such as chimpanzees, bonobos, orangutans and one gorilla species, the team used statistical modeling to estimate when kissing first appeared. Their results, published Nov. 19 in the journal Evolution and Human Behavior, suggest that an ancient ancestor of today’s apes likely engaged in mouth-to-mouth contact between 16.9 million and 21.5 million years ago. Kissing presents an “evolutionary conundrum,” study lead author Matilda Brindle, an evolutionary biologist at Oxford, said to CNN. She said the behavior is surprising because it carries some obvious risks, including spreading germs, and may not directly help with survival. Yet across primate species, kissing and similar behaviors may serve many purposes, Brindle said. These include: finding potential partners foreplay building social bonds soothing tension helping parents feed infants by chewing food first Because the behavior isn’t a fossil, researchers must study living species to better understand the past. The oldest written records of human kissing date back about 4,500 years to ancient Mesopotamia and Egypt. But kissing today…  read on >  read on >

People paying out of pocket for Ozempic or Wegovy may soon see lower costs, as Novo Nordisk rolls out new price discounts for its popular GLP-1 medications. The company announced that through the end of March, patients with prescriptions can buy the two lowest doses of Ozempic and Wegovy for $199 a month for two months. After that, the monthly cost rises to $349. The discounts can be accessed through the drugs’ websites and used at pharmacies or through telehealth. The $199 offer only applies to 0.25 mg and 0.5 mg injections. The higher $349 price covers the 1 mg dose of Ozempic and all Wegovy doses. The 2 mg dose of Ozempic is not included. “The US healthcare system is complex, with different types of insurance and various ways for patients to obtain their medicines,” Dave Moore, Novo Nordisk’s executive vice president of U.S. operations, told NBC News. “Our new savings offers provide immediate impact, bringing forward greater cost savings for those who are currently without coverage or choose to self-pay,” he added. These price cuts come as list prices for both medications remain around $1,000 or more per month. They also follow a recent partnership with Costco, which began offering low-dose Ozempic and Wegovy for $499 per month out of pocket. Novo Nordisk has similar cash-pay deals available through CVS, Walmart and its…  read on >  read on >

Your morning orange juice may be influencing your health in ways you can’t see. In a new study published recently in the journal Molecular Nutrition & Food Research, researchers found that daily OJ intake altered gene activity connected to heart and metabolic function. For the study, 20 healthy adults drank around two cups of 100% orange juice daily for two months. Scientists from universities in Brazil and the United States then examined samples of participants’ immune cells. They tracked changes in more than 1,700 genes, looking for shifts linked to inflammation, blood pressure and how the body uses fat. The team of researchers found broad changes in gene activity after regular orange juice intake. Many of these changes pointed toward reduced inflammation or healthier blood vessel function. But the type of changes varied depending on a person’s body weight. People with a normal weight tended to show shifts in genes tied to inflammation, while those who were overweight showed more changes involving fat metabolism and energy use. Researchers say these effects may be driven by the flavonoids, natural plant compounds found in citrus fruits, berries, tea and cocoa. Flavonoids act as antioxidants and studies have suggested they may help protect the heart, researchers noted. The study “reinforces the therapeutic potential of OJ by providing important and unprecedented insights into the molecular mechanisms behind the effects…  read on >  read on >

Your morning orange juice may be influencing your health in ways you can’t see. In a new study published recently in the journal Molecular Nutrition & Food Research, researchers found that daily OJ intake altered gene activity connected to heart and metabolic function. For the study, 20 healthy adults drank around two cups of 100% orange juice daily for two months. Scientists from universities in Brazil and the United States then examined samples of participants’ immune cells. They tracked changes in more than 1,700 genes, looking for shifts linked to inflammation, blood pressure and how the body uses fat. The team of researchers found broad changes in gene activity after regular orange juice intake. Many of these changes pointed toward reduced inflammation or healthier blood vessel function. But the type of changes varied depending on a person’s body weight. People with a normal weight tended to show shifts in genes tied to inflammation, while those who were overweight showed more changes involving fat metabolism and energy use. Researchers say these effects may be driven by the flavonoids, natural plant compounds found in citrus fruits, berries, tea and cocoa. Flavonoids act as antioxidants and studies have suggested they may help protect the heart, researchers noted. The study “reinforces the therapeutic potential of OJ by providing important and unprecedented insights into the molecular mechanisms behind the effects…  read on >  read on >

Forcing veterans to revisit the horrors that led to their post-traumatic stress disorder (PTSD) might prompt many to drop out of therapy, a new evidence review found. About a quarter of U.S. service members and veterans who start psychotherapy for PTSD quit before they finish treatment, according to a review published Nov. 17 in the journal Psychological Trauma: Theory, Research, Practice, and Policy. But some therapies, while proven to be effective, report higher dropout rates than others, researchers found. Trauma-focused approaches like exposure therapy and cognitive processing therapy tended to have higher dropout rates than approaches focusing on mindfulness, meditation and stress reduction, results show. “Dropout rates remain a significant challenge in PTSD care for military populations,” lead researcher Elizabeth Penix-Smith, a National Research Council fellow at the Walter Reed Army Institute of Research in Silver Spring, Maryland, said in a news release. “Identifying which protocols are more sustainable can help clinicians tailor care and policymakers prioritize treatments that keep patients engaged,” Penix-Smith said. About 7% of veterans suffer from PTSD at some point in their lives, slightly higher than the rate seen among the general public, researchers said in background notes. The disorder can increase risk of heart disease and stroke. For the study, researchers analyzed data from 181 prior studies covering 232 PTSD treatments and more than 124,000 military participants. On average, just…  read on >  read on >

Forcing veterans to revisit the horrors that led to their post-traumatic stress disorder (PTSD) might prompt many to drop out of therapy, a new evidence review found. About a quarter of U.S. service members and veterans who start psychotherapy for PTSD quit before they finish treatment, according to a review published Nov. 17 in the journal Psychological Trauma: Theory, Research, Practice, and Policy. But some therapies, while proven to be effective, report higher dropout rates than others, researchers found. Trauma-focused approaches like exposure therapy and cognitive processing therapy tended to have higher dropout rates than approaches focusing on mindfulness, meditation and stress reduction, results show. “Dropout rates remain a significant challenge in PTSD care for military populations,” lead researcher Elizabeth Penix-Smith, a National Research Council fellow at the Walter Reed Army Institute of Research in Silver Spring, Maryland, said in a news release. “Identifying which protocols are more sustainable can help clinicians tailor care and policymakers prioritize treatments that keep patients engaged,” Penix-Smith said. About 7% of veterans suffer from PTSD at some point in their lives, slightly higher than the rate seen among the general public, researchers said in background notes. The disorder can increase risk of heart disease and stroke. For the study, researchers analyzed data from 181 prior studies covering 232 PTSD treatments and more than 124,000 military participants. On average, just…  read on >  read on >