If you’re one of the millions of Americans walking around with a new knee or hip, your odds for an infection in that joint rise if you ever have to undergo cancer chemotherapy, researchers report. “Given the number of people of receiving total joint replacements each year, as well as the cost both physically, emotionally and financially for those who develop an infection and may need subsequent treatment, we need to understand what factors may increase the risk for postoperative infections,” said study author Dr. Janet Conway. She’s an orthopedic surgeon at the Rubin Institute for Advanced Orthopedics, and is also head of Bone and Joint Infection at Sinai Hospital in Baltimore. Her team tracked outcomes for over 17,000  patients who had undergone total knee replacement, total hip replacement or total shoulder replacement. They looked at people who’d also undergone chemotherapy within a year of their joint replacement surgery. Undergoing chemo appeared tied to a higher odds for an infection in the joint that had been replaced, the team found, compared to folks with new joints who had not undergone chemo. “We became curious about the potential effects of postoperative chemotherapy and the risk of joint infection as we saw cases in our own joint replacement patients,” Conway explained in a Sinai Hospital news release.  “To our knowledge, this is the first study to comprehensively…  read on >  read on >

Memorial Day means firing up that backyard grill for the season, hopefully under warm, sunny skies. You can be sure to enjoy the day without hazards by taking a few simple precautions, said Dr. Mike Ren, an associate professor of family and community medicine at Baylor College of Medicine in Houston. Watch out for rising heat and humidity If Memorial day is a scorcher, hydration is key, Ren said. “A good rule of thumb is to drink water regularly throughout the day, aiming for 12 or more cups; when in the heat, drink one cup (eight ounces) of water roughly every 20 minutes,” he advised. And stay away from substances that can rob your body of water. “Alcohol is a diuretic, meaning it increases urine production and can lead to fluid loss,” Ren noted in a Baylor news release. “On the other hand, sugary drinks can cause spikes and crashes in blood sugar levels,” he added. “Prioritizing water consumption is crucial for maintaining proper hydration levels. If you want to add a little flavor, low or zero-sugar electrolyte powders and supplements can be a good alternative.” Shield your skin from the sun Folks may have forgotten the sun’s dangers as winter and spring ebb away. Dr. John Wolf, professor of dermatology at Baylor, recommends slapping on a sunscreen with an SPF of 30, and using…  read on >  read on >

For decades, the responsibility for birth control has fallen largely on women, but new research suggests a birth control pill for men might one day become a reality. How does it work? It targets a protein required for fertility, scientists report. The protein, called serine/threonine kinase 33 (STK33), is enriched in the testicles and is specifically required to create functional sperm, they explained. A drug that inhibits STK33, called compound CDD-2807, blocked the ability of male lab mice to fertilize female mice, researchers reported May 23 in the journal Science. “We were pleased to see that the mice did not show signs of toxicity from CDD-2807 treatment, that the compound did not accumulate in the brain and that the treatment did not alter testis size,” said researcher Courtney Sutton, a postdoctoral fellow in pathology at Baylor College of Medicine in Houston. “Importantly, the contraceptive effect was reversible,” Sutton added in a Baylor news release. “After a period without compound CDD-2807, the mice recovered sperm motility and numbers and were fertile again.” Previous research had shown that naturally occurring mutations in STK33 leads to infertility in both mice and men by causing abnormal sperm with poor movement. These mutations cause no other health problems. “STK33 is therefore considered a viable target with minimal safety concerns for contraception in men,” said researcher Dr. Martin Matzuk, director of…  read on >  read on >

A mom or dad who vapes at home might be setting their child up for eczema, new research suggests. In a study involving data from over 35,000 U.S. households, children with a parent who used e-cigarettes had a 24% higher odds for eczema (also known as atopic dermatitis) than kids with two non-vaping parents did. “Our results suggest that parental e-cigarette use was associated with pediatric atopic dermatitis,” concluded a team led by Dr. Golara Honari, a clinical associate professor of dermatology at Stanford University, in California. Her team published its findings May 22 in the journal JAMA Dermatology. According to the researchers, there is science backing up the notion that exposure to the toxins emitted in e-cigarette vapor could trigger changes in children’s skin. Prior lab studies have “demonstrated increased oxidative stress in human keratinocytes and 3-dimensional skin models exposed to e-cigarette fluids and aerosol residues,” they noted. Keratinocytes are cells that make up about 90% of the skin’s outer epidermal layer. “We hypothesize that secondhand exposure to e-cigarettes is associated with a similar response among children, elevating atopic dermatitis risk,” the Stanford team wrote. The new study drew on 2014-2018 data from the National Health Interview Survey, involving about 35,000 households. It’s a face-to-face survey of families conducted by the U.S. Centers for Disease Control and Prevention. Parents were asked about any cases…  read on >  read on >