The head of the company that makes the diabetes and obesity drugs Ozempic and Wegovy has warned that compounded versions of the active ingredient in those medications have now been linked to at least 100 hospitalizations and 10 deaths. “Honestly, I’m quite alarmed by what we see in the U.S. now,” Novo Nordisk President and CEO Lars Fruergaard Jorgensen told CNN on Wednesday. “Patients who believe that they’re getting access to a safe product, and they believe they’re getting semaglutide … I know for a fact that they are not getting semaglutide, because there’s only one semaglutide, and that’s produced by Novo Nordisk, and we don’t sell that to others.” Compounded drugs are made by pharmacies or manufacturers other than the companies that make approved versions of those medicines, and they typically are allowed when there is a shortage of those drugs. Semaglutide, and other GLP-1 drugs like it, have experienced shortages in the past two years as millions of Americans have turned to the medications for help with significant weight loss. While semaglutide remains on the shortage list, Novo Nordisk noted last week that the last remaining dose in short supply — the lowest dose of Wegovy — is now listed as available, CNN reported. “We’re collaborating with the FDA, and I think they’re looking into what are some of the considerations they have… read on > read on >
All Eats:
Just 5 Extra Minutes of Exercise Per Day Could Lower Blood Pressure
It doesn’t take much: Adding just five minutes of exercise to your daily routine lowers your blood pressure and might cut your odds for heart disease, new research shows. “The good news is that whatever your physical ability, it doesn’t take long to have a positive effect on blood pressure,” said study lead author Jo Blodgett, from University College London (UCL). “What’s unique about our exercise variable is that it includes all exercise-like activities, from climbing the stairs to a short cycling errand, many of which can be integrated into daily routines.” Her team published its findings Nov. 6 in the journal Circulation. According to the researchers, high blood pressure affects almost 1.3 billion adults globally and is one of the biggest causes of premature death due to stroke and other causes. The new study focused on almost 15,000 adult volunteers who were given activity trackers to chart their daily involvement in six key activities: Sleep Sedentary behavior (such as sitting) Slow walking (less than 100 steps per minute) Fast walking (100 steps per minute or more) Standing More vigorous exercise (such as running, cycling or stair climbing) Each day, the average participant got seven hours of sleep, 10 hours of sedentary behavior such as sitting, three hours of standing, one hour of slow walking, one hour of fast walking and just 16 minutes of… read on > read on >
Fish Oil Supplements Might Help Prevent Cancer
The omega-3 and omega-6 fatty acids in fish oil supplements might help protect people from cancer, a new study claims. Study participants with higher levels of omega-3s had lower rates of colon, stomach, lung and other digestive tract cancers, researchers found. Likewise, high omega-6 levels led to lower rates of 14 different cancers, including brain, melanoma, bladder and more, result showed. “These findings suggest that the average person should focus on getting more of these fatty acids in their diets,” said lead researcher Yuchen Zhang, a doctoral student with the University of Georgia’s College of Public Health. The study relied on data from more than 253,000 participants in the UK Biobank research project. As part of that project, participants filled out dietary questionnaires and had their health tracked for decades. Of those people, nearly 30,000 developed some form of cancer, researchers said. Importantly, the benefits of high levels of fatty acids were independent of other cancer risk factors like BMI, alcohol use or physical activity. These fatty acids are present in fatty fish, nuts and plant-based cooking oils, but many people turn to fish oil supplements to make sure they’re getting enough. However, the benefits of these fatty acids aren’t universal. The researchers noted that high omega-3 levels could be associated with a slightly higher risk of prostate cancer. “For women, it’s an easy decision:… read on > read on >
Text-Messaging Program Helps Parents Keep Infants at Healthy Weight
Text messages and other online feedback can help prevent obesity in very young children, a new study demonstrates. Kids had a healthier weight-for-height growth curve during their first two years if parents were offered electronic feedback on feeding habits, playtime and exercise, researchers found. “What is kind of exciting from our study is we prevented those children who would have had an unhealthy weight in the first place and helped them have a healthier weight, which sets them up better for health throughout their lives,” said co-lead researcher Dr. Eliana Perrin, a professor of primary care at the Johns Hopkins University Schools of Medicine, Nursing and Public Health in Baltimore. About 1 in 5 school-aged kids were obese in 2017-2018, and these rates are expected to have increased since the pandemic, researchers said. In a prior study, Perrin and her colleagues found that in-clinic counseling improved healthy growth in newborns up to 18 months of age, but not through the age of 2. That might be because pediatric office visits become less frequent past a child’s first year of life, the researchers reasoned. Given that, they created a follow-up study focusing on using digital technology to continue providing health and diet counseling for new parents, even if they’re no longer dropping by a doctor’s office. “We found that parents are eager for more information to… read on > read on >
Halloween Candy: Don’t Get Spooked by All That Sugar
Sugar overload is a real danger on Halloween, as piles of candy prove a powerful temptation to both Trick-or-Treaters and the folks handing out the goodies. Too many sweet treats can instigate a blood sugar spike followed by a hard crash, causing folks to become irritable and experience symptoms like dizziness, upset stomach, tiredness and headache, said Luis Rustveld, an associate professor of family and community medicine at Baylor College of Medicine in Houston. “Sugar gets broken down into glucose by your body and travels through your bloodstream, signaling the pancreas to make insulin, which helps your cells convert glucose into energy,” Rustveld explained in a Baylor news release. “Too much sugar overwhelms the system, resulting in spikes in blood glucose levels.” The best way to prevent both kids and adults from overloading on sugar is to start the night with a normal, balanced meal, Rustveld advised. Slow-digesting protein from the meal will help blunt blood sugar spikes, and a fuller stomach will lower the desire to munch on too much candy, he said. It’s also good to get in some physical activity — either lots of steps Trick-or-Treating around the neighborhood, or working out earlier in the day — to help maintain a balance between exercise and the added sugar in a Halloween diet, Rustveld said. He advised parents to stick with the American… read on > read on >
More Kids With Food Allergies Are Needing Psychological Care
Anxiety is driving more children with potentially dangerous food allergies to seek out psychological care, a new study finds. Focusing on one Ohio hospital, the researchers found a more than 50% jump in psychology referrals for kids with food allergies between 2018 and 2023. “Our center has devoted significant resources to address the psychosocial support needed by many families who have children with food allergies,” said study lead author Dr. Andriana La Mantia, a pediatrician at Nationwide Children’s Hospital in Columbus, Ohio. “Our goal in this study was to characterize use of these services for food allergy-related anxiety,” La Mantia said in a news release from the American College of Allergy, Asthma and Immunology (ACAAI). Her team presented its findings Thursday at the ACAAI annual meeting in Boston. Food allergies can bring the specter of analphylaxis: A sudden, potentially life-threatening allergic reaction to even small amounts of the food allergen. Anxiety around preventing these incidents and trauma resulting from anaphylactic episodes can harm a child’s mental health. “Food allergy patients, particularly children, often suffer from anxiety related to potential accidental ingestion and anaphylaxis,” said study co-author Dr. David Stukus, director of the Food Allergy Treatment Center at Nationwide Children’s Hospital. In the new study, the Columbus team reviewed the cases of 250 kids with food allergies, who averaged 9.5 years of age. Many were allergic to… read on > read on >
FDA Appoints New Head of Medical Devices
The U.S. Food and Drug Administration announced Tuesday that it has appointed Dr. Michelle Tarver to head its division that oversees medical devices. The appointment of a new director for the Center for Devices and Radiological Health comes at a time of great innovation and change in the medical device field, with AI playing an increasing role in medical technologies. Tarver replaces outgoing director Dr. Jeffrey Shuren, who faced criticism over ethical lapses during his 15 years of running an agency with close ties to the medical device industry. Shuren announced his retirement in July. “Dr. Tarver demonstrates a true passion about data, science, medicine and the evidence, all of which are critical to supporting and driving the FDA’s decisions,” FDA Commissioner Dr. Robert Califf said in an announcement to agency staff, the New York Times reported. “She works to build collaboration and transparency in achieving the strategic priorities for the center and the agency.” Tarver said in a statement that she was honored to lead the division and planned to “remain committed in our service to public health and ensuring all patients in the U.S. have access to high-quality, safe and effective medical devices.” According to the Times, the FDA’s medical device division has a budget of $790 million and a staff of over 2,500 people. It oversees the development of thousands of devices used… read on > read on >
Cutting Back on Carbs Could Help Folks With Type 2 Diabetes
Type 2 diabetes is caused in part by the failure of pancreatic beta cells to respond as they should to blood sugar. Now, new research suggests that switching to a low-carbohydrate diet might correct that beta cell dysfunction, boosting patients’ health. “People with type 2 diabetes on a low-carbohydrate diet can recover their beta cells, an outcome that cannot be achieved with medication,” noted lead study author Barbara Gower, of the University of Alabama at Birmingham. The findings suggest that “people with mild type 2 diabetes who reduce their carbohydrate intake may be able to discontinue medication and enjoy eating meals and snacks that are higher in protein and meet their energy needs,” Gower added in a news release from the Endocrine Society. As the research team explained, type 2 diabetes — by far the most common form of the disease — is caused in part by an impairment in beta-cell function and loss of beta cells. Beta cells are made in the pancreas and produce insulin, the hormone humans need to control blood sugar levels. Her team theorized that damage to beta cells may be due, at least in part, to excessive intake of carbohydrate-rich foods such as bread and pasta. In the new study, the Birmingham team placed 57 white and Black adults with type 2 diabetes on one of two dietary regimens.… read on > read on >
Could Dirty Air Raise Kids’ Odds for Peanut Allergy?
Babies who breathe in polluted air tend to have higher rates of peanut allergy as they grow up, but the same wasn’t true for immune-based conditions like egg allergy or eczema, Australian researchers report. Why the connection to peanut allergy in particular? That’s not yet clear, said study lead author Dr. Diego Lopez, of the University of Melbourne. “Air pollutants have an irritant and inflammatory effect that may boost the immune systems pro-allergic response, potentially triggering the development of food allergies,” said Lopez, a researcher at the university’s School of Population and Global Health. “However, the underlying mechanisms of how air pollution increases the risk of a peanut allergy, and why eczema and egg allergy aren’t impacted in the same way, need to be explored further,” he said in a news release from the Murdoch Childrens Research Institute (MCRI). The new research involved nearly 5,300 children living in Melbourne who’d been enrolled at the age of 1 and then followed up at ages 4, 6 and 10. Lopez’ team was able to track local data on air pollution for whatever neighborhood the child lived in. They looked specifically at two types of pollution: fine particulate matter (PM2.5) and nitrogen dioxide (NO2). As rates of air pollution rose, so did a child’s odds of developing a peanut allergy, the team found. Food allergies were diagnosed using… read on > read on >
Could Caffeine in Pregnancy Help Prevent Cerebral Palsy in Kids?
Experiments in sheep are hinting that doses of caffeine given to women in pregnancy, as well as their newborns after birth, could prevent cerebral palsy. Cerebral palsy is a disabling condition often caused by asphyxia — reductions in oxygen supply — around the time of birth. Asphyxia can cause other neurodevelopmental disorders, as well. Researcher Dr. Emin Maltepe, a neonatologist at the University of California, San Francisco’s Benioff Children’s Hospital, explained how caffeine might prevent asphyxia damage. “Caffeine has previously proven to be safe in stimulating the respiratory centers of preterm babies and helping them remember to breathe,” said Maltepe, who is senior author of the new study. Caffeine “easily crosses the blood-brain barrier and is a potent antioxidant and anti-inflammatory molecule,” added first study author Dr. Jana Mike, a pediatric intensivist at the same hospital. Maltepe and Mike published their findings Oct. 21 in the journal Stroke. In the new study, 30 pregnant sheep received either a single intravenous dose of one gram of caffeine, which is equal to about 10 cups of coffee, or a placebo IV shot. Then, after their lambs were born and asphyxia was induced, some lambs got a large dose of caffeine followed by lesser doses each day for two days. The other lambs received the placebo. Measures of systemic inflammation, called cytokines, were significantly less among lambs… read on > read on >