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MONDAY, Jan. 13, 2025 (HealthDay news) — The sleep aid Ambien could be allowing toxic proteins to pollute the brain, potentially increasing a person’s risk of disorders like Alzheimer’s disease. Drugs like the main ingredient in Ambien, zolpidem, suppresses a system designed to clear protein waste from the brain during dreamless sleep, a mouse study published Jan. 8 in the journal Cell shows. The study “calls attention to the potentially detrimental effects of certain pharmacological sleep aids on brain health, highlighting the necessity of preserving natural sleep architecture for optimal brain function,” senior researcher Dr. Maiken Nedergaard, co-director of the University of Rochester Center for Translational Neuromedicine, said in a news release. For the study, researchers used brain imaging along with electrical brain readings to track the activity in lab mice of the glymphatic system, a brain-wide network responsible for clearing away waste proteins. They found that tightly synchronized oscillations occur in the brain during deep sleep, involving cerebral blood, spinal fluid and the biochemical norepinephrine. Norepinephrine is a brain chemical involved in the “fight or flight” response, and is associated with arousal, attention and stress. During sleep, norepinephrine triggers rhythmic constriction of blood vessels independent of a person’s heartbeat, researchers found. This oscillation generates the pumping action that powers the glymphatic system, which removes toxic proteins like tau and amyloid — proteins known to… read on > read on >