All Sauce from Weekly Gravy:

The GLP-1 drug semaglutide can help obese people manage debilitating knee arthritis, a new trial has found. People who received weekly injections of semaglutide — the active agent in the diabetes drug Ozempic and the weight-loss medication Wegovy — had a nearly 14% decrease in their body weight after 68 weeks, compared with 3% of people given a placebo, results showed. The trial was funded by Novo Nordisk, the drug company that makes semaglutide. This weight loss translated into a decrease in knee pain and improved knee function among those taking semaglutide, researchers reported Oct. 30 in the New England Journal of Medicine. “Obesity-related knee osteoarthritis is a progressive condition that can lead to pain and stiffness of the knee and impair critical daily functions such as walking or moving around,” said lead researcher Dr. Henning Bliddal, a professor of rheumatology with Copenhagen University Hospital in Denmark. “The risk of developing the condition is more than four times higher in people with obesity,” Bliddal added in a Novo Nordisk news release. Added weight places more stress on the knee, causing the natural cartilage that cushions the joint to wear down more quickly, experts say. Dropping excess pounds is often recommended to treat knee arthritis, but it can be tough to achieve through diet and exercise alone, Bliddal noted. For this study, researchers recruited 407 adults…  read on >  read on >

Hillary Fisher thinks receiving weight-loss surgery as a teenager put her on the path to a better life. Fisher is one of 260 teens who participated in a long-term study which recently concluded that weight-loss surgery can bring lasting health benefits for obese teenagers. “It changed my life,” Fisher, now 31, said in a news release. “The improved health and self-esteem that came with the 100-pound weight loss were important to me and I would certainly do it again.” Fisher was not alone in her success: The surgery led to substantial and sustained weight loss for more than half of the study’s participants during a decade of follow-up, researchers reported Oct. 30 in the New England Journal of Medicine. The teens also had fewer obesity-related health problems in adulthood like type 2 diabetes, high blood pressure and elevated cholesterol, researchers report. “Our study presents impressive outcomes of the longest follow-up of weight-loss surgery during adolescence, which validates bariatric surgery as a safe and effective long-term obesity management strategy,” said lead investigator Justin Ryder, vice chair of research for the Department of Surgery at Ann & Robert H. Lurie Children’s Hospital of Chicago. Fisher decided to undergo the surgery at age 16. “I was crushed by the daily issues I faced due to my weight, health problems and bullying in high school,” Fisher said. “After many…  read on >  read on >

Smokers diagnosed with cancer often shrug and keep lighting up, figuring a few more butts won’t make much difference. They’re very mistaken, a new study finds. Smokers are 22% to 26% less likely to die if they quit following a cancer diagnosis, researchers found. The best outcomes occurred in patients who quit within six months of their cancer diagnosis and remained off the butts for at least three months, researchers reported Oct. 31 in the journal JAMA Oncology. “While smoking cessation is widely promoted across cancer centers for cancer prevention, it remains under-addressed by many oncologists in their routine care,” said principal investigator Paul Cinciripini, chair of behavioral science and executive director of the Tobacco Research and Treatment Program at the University of Texas MD Anderson Cancer Center. “Our research underscores the critical role of early smoking cessation as a key clinical intervention for patients undergoing cancer treatment,” Cinciripini added in an MD Anderson news release. For the study, researchers followed more than 4,500 smokers who had been diagnosed with cancer and were in a quit smoking program at MD Anderson. Nearly all of the quit support was provided via telemedicine. Cancer patients who successfully abstained from smoking had an average survival of four years, compared with two years for those who couldn’t quit, results show. “This is a call to action for experts, regulatory…  read on >  read on >

Doctors in New York City are describing the first known U.S. cases of sexually transmitted ringworm, which can cause a nasty rash that can take months to bring under control. Despite the name, ringworm isn’t any kind of worm but instead is a fungus, Trichophyton mentagrophytes. It’s more commonly known as jock itch (when it affects the groin area) or athlete’s foot, and can produce a round, itchy rash. Until now, transmission of the fungal infection through skin-to-skin sexual contact has been rare, although cases have been reported in Southeast Asia and France since 2021, researchers reported. These have been a subtype of T. mentagrophytes called TMVII. The new report concludes that the first U.S. case of sexually transmitted TMVII was reported in June, and “four additional TMVII infections were diagnosed during April-July 2024 in New York City among men who have sex with men.” The rash appeared “on the [patients’] face, buttocks or genitals, and was successfully treated with antifungal medications,” said a team led by dermatologist Dr. Avrom Caplan, of NYU Langone Health in New York City. His team published its findings Oct. 31 in Morbidity and Mortality Weekly Report, a journal of the U.S. Centers for Disease Control and Prevention. According to the report, all five cases of sexually transmitted ringworm so far documented in the United States involved gay or bisexual…  read on >  read on >

If anxiety over this year’s presidential election is keeping you up at night, you’re not alone. About 17% of all U.S. adults — a striking 45 million Americans — say the election has negatively impacted their sleep, according to a survey by the National Sleep Foundation. These folks are sleeping less on the weekend and have poorer sleep quality overall, the survey found. The negative impact on sleep of the 2024 presidential election cut across all groups, including political party affiliation, results showed. “The dynamics of stressful societal events like elections and election day can adversely affect the public’s mood, and in turn sleep health, which is critical for health and well-being,” Joseph Dzierzewski, senior vice president for research and scientific affairs at the National Sleep Foundation (NSF), said in an NSF news release. “This reinforces the importance of addressing sleep health during periods of high stress.” Anxiety and sleeplessness can feed on each other, sleep experts say. People who are anxious get poorer sleep, and people who don’t sleep well are more prone to anxiety. People affected by the election are getting about 7 hours of sleep on the weekend, nearly a half hour less than those who say their sleep hasn’t been disturbed by politics, results showed. On a scale of 1 to 5 (1 being excellent and 5 being poor), those worried…  read on >  read on >

The COVID-19 pandemic appears to have created a nation of homebodies in the United States, a new study finds. People are spending nearly an hour less each day doing activities outside the home, researchers reported Oct. 31 in the Journal of the American Planning Association. In essence, not going out has become the “new normal” post-COVID, experts say. Since 2019, there’s been an overall drop of about 51 minutes in the daily time spent on out-of-home activities, researchers found. People also spend about 12 minutes less time on daily travel in cars or public transportation. This decrease in time spent away from home appears to be a lasting consequence of the pandemic, researchers said, and it will affect society on many levels. For example, cities will need to rethink their dependence on folks who commute in for their workdays, noted the researchers, who are urban planners. “In a world where cities cannot rely on captive office workers and must work to attract residents, workers and customers, local officials might seek to invest more heavily in their remaining strengths,” said lead study author Eric Morris, a professor of city and regional planning at Clemson University in South Carolina. “These include opportunities for recreation, entertainment, culture, arts and more,” Morris added in a journal news release. “Central cities might shift toward becoming centers of consumption more than…  read on >  read on >

Sugar overload is a real danger on Halloween, as piles of candy prove a powerful temptation to both Trick-or-Treaters and the folks handing out the goodies. Too many sweet treats can instigate a blood sugar spike followed by a hard crash, causing folks to become irritable and experience symptoms like dizziness, upset stomach, tiredness and headache, said Luis Rustveld, an associate professor of family and community medicine at Baylor College of Medicine in Houston. “Sugar gets broken down into glucose by your body and travels through your bloodstream, signaling the pancreas to make insulin, which helps your cells convert glucose into energy,” Rustveld explained in a Baylor news release. “Too much sugar overwhelms the system, resulting in spikes in blood glucose levels.” The best way to prevent both kids and adults from overloading on sugar is to start the night with a normal, balanced meal, Rustveld advised. Slow-digesting protein from the meal will help blunt blood sugar spikes, and a fuller stomach will lower the desire to munch on too much candy, he said. It’s also good to get in some physical activity — either lots of steps Trick-or-Treating around the neighborhood, or working out earlier in the day — to help maintain a balance between exercise and the added sugar in a Halloween diet, Rustveld said. He advised parents to stick with the American…  read on >  read on >

Half of young Americans between the ages of 12 and 17 spend at least four hours each day on their smartphones, computers or televisions, a new survey shows. “As technology has become more integrated into teenagers’ lives, the time spent in front of screens has continued to rise in the United States,” noted a team of researchers from the U.S. Centers for Disease Control and Prevention. All of that screen time might not be great for teens’ psyches: The research found that while about 27% of teens who had four or more hours per day of screen time said they’d had anxiety over the past two weeks, that was true for only 12.3% of teen with fewer hours spent looking at screens. Self-reported depression levels were also much higher (about 26%) among teens who consumed four hours or more of screen time than those who didn’t (9.5%). The new data comes from answers given by U.S. teens to a federal survey conducted between mid-2021 and the end of 2023. The survey found little difference in screen use by gender — just over 48% of boys watched TV or stared at their phones or computers for four or more hours per day, as did 52.5% of girls. Screen time did seem to rise with age, however: While 45.6% of kids ages 12 to 14 spent four…  read on >  read on >

Find it hard to take time to exercise during your busy workweek? No problem, a new study says — one or two “weekend warrior” workouts are just as likely to help you maintain your brain health. People who regularly exercise, whether solely on the weekend or throughout the week, are more likely to stay sharp as they age compared to people who never work out, researchers found. About 13% of cases of mild cognitive impairment might be avoided if all middle-aged adults exercised at least once or twice a week, researchers estimated. “This study is important because it suggests that even busy people can gain cognitive health benefits from taking part in one or two sessions of sport and exercise per week,” concluded the research team led by Gary O’Donovan, an adjunct professor of sport science with Los Andes University in Bogota, Colombia. For the study, researchers analyzed data from more than 10,000 people in Mexico City. All participants were asked how often they worked out or played sports, and they also took part in a cognitive function test. Weekend warriors worked out once or twice a week, while regularly active people said they exercised three or more times a week. During an average follow-up period of 16 years, about 26% of the people who never exercised developed mild cognitive impairment, compared with 14% among…  read on >  read on >

People who regularly use marijuana experience changes in their brain structure and function, but it’s not clear that cannabis is the cause, a new study finds. Researchers found specific differences in the brains of people who’d ever used weed, particularly in areas densely packed with cannabinoid receptors. However, genetic analysis couldn’t pin down any specific association between cannabis use and these brain changes. This means some other factor besides weed might be causing these brain changes in marijuana users. “Our results need to be interpreted with careful consideration,” concluded the research team led by Saba Ishrat, a doctoral student in psychiatry with the University of Oxford in the U.K. “Additional research is needed to understand the effects of heavy cannabis use in this population, including considerations of potency and related information, to inform public policy.” For the study, researchers analyzed data on nearly 15,900 weed users participating in the U.K. Biobank research project for whom genetic profiling and MRI brain scans were available. Looking at the brains of the marijuana users, researchers found that they had poorer integrity of their “white matter,” the part of the brain that connects different brain regions. This was particularly evident in the corpus callosum, which serves as the main route of communication between the left and right sides of the brain. Weed users also had weaker neural connections in…  read on >  read on >