Folks might want to try timing their COVID-19 booster vaccine to coincide with a period of increased transmission in their area, a new study suggests. Doing so can improve protection against COVID infection as much as fourfold compared to getting the jab when the coronavirus isn’t spreading as much, researchers report in the journal Clinical Infectious Diseases. “Timing is everything when it comes to COVID-19 boosters,” lead researcher Jeffrey Townsend, a professor of biostatistics at the Yale School of Public Health, said in a news release. “Our research shows that receiving your booster shot at the right time can make a significant difference in your protection against infection,” he said. “By tailoring booster schedules to local COVID-19 patterns, we can help ensure people are best protected when they need it most.” Results show that receiving a booster in September or October provides three to four times more protection against infection in the U.S., compared to shots given later in the year. For example, New Yorkers can get the best protection by getting their booster on Sept. 15, the study found. Waiting until January reduces its effectiveness by 3.6-fold. Ideally, booster shots should precede peak COVID periods by just under three months, the study found. That gives the shot a chance to maximize protection just as the virus starts to circulate, researchers said. Delaying booster shots…  read on >  read on >

Concussion-related brain damage can combine with a family history of mental illness to make some athletes and military personnel prone to aggression and violence in middle age, a new study says.  People with chronic traumatic encephalopathy (CTE) are at higher risk of mood changes and dementia, but this study shows that aggression is another risk posed by the condition. “This appears to be a case where together these risk factors add up to a greater risk for aggression than they each do on their own, where people with CTE and a family history of mental illness are much more likely to have aggressive behavior than those with just CTE or just the family history,” researcher Dr. Jesse Mez, an associate professor of neurology with the Boston University Chobanian & Avedisian School of Medicine, said in a news release. Some individual cases have already highlighted the potential link between CTE and violence. For example, former New England Patriots tight end Aaron Hernandez hanged himself in jail at age 27 following his conviction for the murder of a friend. Autopsy of his brain revealed it was riddled with CTE damage, particularly in regions associated with decision-making and judgment. In this study, researchers looked at 845 men exposed to repetitive head impacts through contact sports or military service, including 329 who played professional football. All donated their brains…  read on >  read on >

The collected evidence is in, and drinking about eight cups of water per day is, in fact, good for you. So says a University of California San Francisco team who crunched the data from 18 randomized controlled trials. “For such a ubiquitous and simple intervention, the evidence hasn’t been clear and the benefits were not well-established, so we wanted to take a closer look,” explained study senior author Dr. Benjamin Breyer, chair of the university’s Department of Urology.   “To our knowledge, this is the first study assessing the benefits of water consumption on clinical outcomes broadly,” he said in a university news release. Breyer’s team published its findings Nov. 25 in JAMA Network Open. The best evidence that lots of water is good for you came from studies citing its power to prevent kidney stones, and to also help folks lose weight. If you’ve had a kidney stone, drinking eight cups of water each day can help prevent a recurrence, the evidence showed.  Drinking six or more cups of water per day also seemed to help adults shed excess pounds, studies showed, although eight cups per day didn’t help teens lose weight. Headaches seemed to ease in frequency if adults upped their water intake, and other trials found that lots of water could help prevent migraines and urinary tract infections. Having about four cups…  read on >  read on >

The outgoing Biden administration will propose that pricey GLP-1 obesity medications such as semaglutide (Wegovy), and tirzepatide (Zepbound) be covered by Medicare and Medicaid. However, the move would have to be approved by the new Trump administration.  Right now, a law passed by Congress two decades ago prevents the Medicare and Medicaid from covering any “weight loss” drug.  Under the Biden proposal, that rule would be circumvented by calling the medications treatments for the disease of obesity and its related health issues.  “We don’t want to see people having to wait until they have these additional diseases before they get treatment,” Chiquita Brooks-LaSure, the administrator of the Centers for Medicare and Medicaid Services (CMS), told The New York Times. Under the proposed rule, every state Medicaid program would be required to cover the cost of the medications, which currently are priced at more than $1,200 per month before any drug company discounts. According to CMS estimates, passage of the rule would open access to the weight-loss medications to 3.4 million potential new patients under Medicare and another 4 million under Medicaid.  But the incoming Trump administration would need to sign off on the new legislation. The person tapped by the president-elect to head the Department of Health and Human Services, Robert F. Kennedy, Jr, has long been a skeptic of the drugs, asserting that weight…  read on >  read on >